ID:TIM10_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import inner membrane translocase subunit Tim10; FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. SUBUNIT: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B. INTERACTION: Q9Y5J7:TIMM9; NbExp=5; IntAct=EBI-1200391, EBI-1200370; SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. TISSUE SPECIFICITY: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. DOMAIN: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable). SIMILARITY: Belongs to the small Tim family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62072
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0007605 sensory perception of sound GO:0015031 protein transport GO:0045039 protein import into mitochondrial inner membrane GO:0072321 chaperone-mediated protein transport
Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005744 mitochondrial inner membrane presequence translocase complex GO:0005758 mitochondrial intermembrane space GO:0016020 membrane GO:0042719 mitochondrial intermembrane space protein transporter complex GO:0042721 mitochondrial inner membrane protein insertion complex
Descriptions from all associated GenBank mRNAs
BC032133 - Homo sapiens translocase of inner mitochondrial membrane 10 homolog (yeast), mRNA (cDNA clone MGC:29523 IMAGE:4761702), complete cds. AF150089 - Homo sapiens small zinc finger-like protein (TIM10) mRNA, complete cds. JD172081 - Sequence 153105 from Patent EP1572962. AK289751 - Homo sapiens cDNA FLJ76375 complete cds, highly similar to Homo sapiens translocase of inner mitochondrial membrane 10 homolog (yeast) (TIMM10), mRNA. JD347259 - Sequence 328283 from Patent EP1572962. AF152354 - Homo sapiens TIMM10 mRNA, complete cds. KJ893569 - Synthetic construct Homo sapiens clone ccsbBroadEn_02963 TIMM10 gene, encodes complete protein. DQ578189 - Homo sapiens piRNA piR-46301, complete sequence. DQ579709 - Homo sapiens piRNA piR-47821, complete sequence. JD409627 - Sequence 390651 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P62072 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
