Human Gene TIMM13 (ENST00000215570.8_7) from GENCODE V47lift37

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Description: translocase of inner mitochondrial membrane 13 (from RefSeq NM_012458.4)
Gencode Transcript: ENST00000215570.8_7
Gencode Gene: ENSG00000099800.8_10
Transcript (Including UTRs)
Position: hg19 chr19:2,425,623-2,427,584 Size: 1,962 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr19:2,426,946-2,427,531 Size: 586 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:2,425,623-2,427,584)			mRNA (may differ from genome)		Protein (95 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TIM13_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import inner membrane translocase subunit Tim13; FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. SUBUNIT: Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. TISSUE SPECIFICITY: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. DOMAIN: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). SIMILARITY: Belongs to the small Tim family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TIMM13 Diseases sorted by gene-association score: mohr-tranebjaerg syndrome (7), mitochondrial metabolism disease (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C023514 2,6-dinitrotoluene D000638 Amiodarone D000643 Ammonium Chloride D002945 Cisplatin D002995 Clofibric Acid D003300 Copper D004051 Diethylhexyl Phthalate D004052 Diethylnitrosamine D004397 Fonofos D005839 Gentamicins more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 115.14 RPKM in Adrenal Gland Total median expression: 2860.09 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-13.60	53	-0.257	Picture	PostScript	Text
3' UTR	-611.50	1323	-0.462	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004217 - Tim8/9/10/13_Znf-like

Pfam Domains:
PF02953 - Tim10/DDP family zinc finger

SCOP Domains:
47565 - Insect pheromone/odorant-binding proteins
144122 - Tim10-like

ModBase Predicted Comparative 3D Structure on Q9Y5L4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008270 zinc ion binding GO:0008565 protein transporter activity GO:0046872 metal ion binding Biological Process: GO:0006626 protein targeting to mitochondrion GO:0007605 sensory perception of sound GO:0015031 protein transport GO:0045039 protein import into mitochondrial inner membrane GO:0072321 chaperone-mediated protein transport Cellular Component: GO:0001650 fibrillar center GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0016020 membrane GO:0042719 mitochondrial intermembrane space protein transporter complex

Descriptions from all associated GenBank mRNAs


	AK024764 - Homo sapiens cDNA: FLJ21111 fis, clone CAS05384, highly similar to AF144700 Homo sapiens small zinc finger-like protein (TIM13) mRNA. JD196154 - Sequence 177178 from Patent EP1572962. JD133080 - Sequence 114104 from Patent EP1572962. JD105222 - Sequence 86246 from Patent EP1572962. JD381581 - Sequence 362605 from Patent EP1572962. JD252198 - Sequence 233222 from Patent EP1572962. JD415431 - Sequence 396455 from Patent EP1572962. JD397371 - Sequence 378395 from Patent EP1572962. JD536719 - Sequence 517743 from Patent EP1572962. JD496382 - Sequence 477406 from Patent EP1572962. DQ577994 - Homo sapiens piRNA piR-46106, complete sequence. JD550579 - Sequence 531603 from Patent EP1572962. JD493316 - Sequence 474340 from Patent EP1572962. JD282425 - Sequence 263449 from Patent EP1572962. JD296959 - Sequence 277983 from Patent EP1572962. JD403434 - Sequence 384458 from Patent EP1572962. JD455741 - Sequence 436765 from Patent EP1572962. JD344305 - Sequence 325329 from Patent EP1572962. JD314437 - Sequence 295461 from Patent EP1572962. JD117660 - Sequence 98684 from Patent EP1572962. JD232516 - Sequence 213540 from Patent EP1572962. JD276786 - Sequence 257810 from Patent EP1572962. JD296626 - Sequence 277650 from Patent EP1572962. JD434450 - Sequence 415474 from Patent EP1572962. JD279015 - Sequence 260039 from Patent EP1572962. AF144700 - Homo sapiens small zinc finger-like protein (TIM13) mRNA, complete cds. BC008607 - Homo sapiens translocase of inner mitochondrial membrane 13 homolog (yeast), mRNA (cDNA clone MGC:9652 IMAGE:3453921), complete cds. JD294659 - Sequence 275683 from Patent EP1572962. JD456510 - Sequence 437534 from Patent EP1572962. JD346953 - Sequence 327977 from Patent EP1572962. JD402488 - Sequence 383512 from Patent EP1572962. JD019994 - Sequence 1018 from Patent EP1572962. AF152352 - Homo sapiens TIMM13b mRNA, complete cds. DQ891755 - Synthetic construct clone IMAGE:100004385; FLH179621.01X; RZPDo839A08132D translocase of inner mitochondrial membrane 13 homolog (yeast) (TIMM13) gene, encodes complete protein; nuclear gene for mitochondrial product. DQ894937 - Synthetic construct Homo sapiens clone IMAGE:100009397; FLH179617.01L; RZPDo839A08131D translocase of inner mitochondrial membrane 13 homolog (yeast) (TIMM13) gene, encodes complete protein; nuclear gene for mitochondrial product. DQ599609 - Homo sapiens piRNA piR-37675, complete sequence. JD020645 - Sequence 1669 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9Y5L4 (Reactome details) participates in the following event(s): R-HSA-1307802 MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds R-HSA-1299484 TIMM8:TIMM13 chaperones hydrophobic proteins R-HSA-1268020 Mitochondrial protein import R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: ENST00000215570.1, ENST00000215570.2, ENST00000215570.3, ENST00000215570.4, ENST00000215570.5, ENST00000215570.6, ENST00000215570.7, NM_012458, P62206, Q9UHL8, Q9WTL1, Q9Y5L4, TIM13B, TIM13_HUMAN, TIMM13A, TIMM13B, uc317cme.1, uc317cme.2 UCSC ID: ENST00000215570.8_7 RefSeq Accession: NM_012458.4 Protein: Q9Y5L4 (aka TIM13_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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