ID:TI17B_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import inner membrane translocase subunit Tim17-B; FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. SUBUNIT: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expression is abundant in heart and skeletal muscle, intermediate in brain, and weak in pancreas, placenta, kidney and liver. SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02466 - Tim17/Tim22/Tim23/Pmp24 family
ModBase Predicted Comparative 3D Structure on O60830
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0030150 protein import into mitochondrial matrix
Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005744 mitochondrial inner membrane presequence translocase complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0031305 integral component of mitochondrial inner membrane
Descriptions from all associated GenBank mRNAs
LF385298 - JP 2014500723-A/192801: Polycomb-Associated Non-Coding RNAs. AJ005895 - Homo sapiens mRNA for (JM3) preprotein translocase, complete CDS (clone IMAGE 345224 and LLOXNC01U138D3 (Baylor College)). BC010142 - Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast), mRNA (cDNA clone MGC:19550 IMAGE:4300787), complete cds. AF077039 - Homo sapiens inner mitochondrial membrane translocase TIM17 homolog mRNA, nuclear gene encoding mitochondrial protein, complete cds. BC091473 - Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast), mRNA (cDNA clone IMAGE:30338742), with apparent retained intron. BC028017 - Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast), mRNA (cDNA clone IMAGE:5216715), with apparent retained intron. AF034790 - Homo sapiens inner mitochondrial membrane translocase Tim17b mRNA, nuclear gene encoding mitochondrial protein, complete cds. LF379121 - JP 2014500723-A/186624: Polycomb-Associated Non-Coding RNAs. JD121331 - Sequence 102355 from Patent EP1572962. JD544440 - Sequence 525464 from Patent EP1572962. JD142699 - Sequence 123723 from Patent EP1572962. AK290207 - Homo sapiens cDNA FLJ76530 complete cds, highly similar to Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast) (TIMM17B), mRNA. JD277202 - Sequence 258226 from Patent EP1572962. JD468742 - Sequence 449766 from Patent EP1572962. KJ892974 - Synthetic construct Homo sapiens clone ccsbBroadEn_02368 TIMM17B gene, encodes complete protein. LF379120 - JP 2014500723-A/186623: Polycomb-Associated Non-Coding RNAs. JD024949 - Sequence 5973 from Patent EP1572962. JD030186 - Sequence 11210 from Patent EP1572962. LF379119 - JP 2014500723-A/186622: Polycomb-Associated Non-Coding RNAs. JD025294 - Sequence 6318 from Patent EP1572962. BC029446 - Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast), mRNA (cDNA clone IMAGE:4696481), partial cds. MA620875 - JP 2018138019-A/192801: Polycomb-Associated Non-Coding RNAs. MA614698 - JP 2018138019-A/186624: Polycomb-Associated Non-Coding RNAs. MA614697 - JP 2018138019-A/186623: Polycomb-Associated Non-Coding RNAs. MA614696 - JP 2018138019-A/186622: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60830 (Reactome details) participates in the following event(s):
R-HSA-1299481 TIMM9:TIMM10 binds hydrophobic proteins R-HSA-1299480 Precursor proteins enter TIMM23 PAM R-HSA-1299487 Precursor proteins enter TIMM23 SORT R-HSA-1299475 TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix R-HSA-1299482 TIMM23 SORT inserts proteins into inner membrane R-HSA-1955380 TIMM9:TIMM10 transfers proteins to TIMM22 R-HSA-1299478 MPP cleaves targeting peptide (presequence) of matrix precursors R-HSA-1299476 MPP cleaves targeting peptide (presequence) of inner membrane precursors R-HSA-1268020 Mitochondrial protein import R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
