Human Gene TIMM22 (ENST00000327158.5_4) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: TIM22_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial import inner membrane translocase subunit Tim22; AltName: Full=Testis-expressed sequence 4;
FUNCTION: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
SUBUNIT: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR003397 - Tim17/Tim22/Tim23/PMP24
Pfam Domains:
PF02466 - Tim17/Tim22/Tim23/Pmp24 family
ModBase Predicted Comparative 3D Structure on Q9Y584
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC002324 - Homo sapiens translocase of inner mitochondrial membrane 22 homolog (yeast), mRNA (cDNA clone MGC:2678 IMAGE:2819655), complete cds.
AK000830 - Homo sapiens cDNA FLJ20823 fis, clone ADSE00282.
AK225453 - Homo sapiens mRNA for translocase of inner mitochondrial membrane 22 homolog, clone: HSI02307.
AF155330 - Homo sapiens putative membrane protein (TIM22) mRNA, complete cds.
KJ898746 - Synthetic construct Homo sapiens clone ccsbBroadEn_08140 TIMM22 gene, encodes complete protein.
JD535843 - Sequence 516867 from Patent EP1572962.
JD207122 - Sequence 188146 from Patent EP1572962.
JD533448 - Sequence 514472 from Patent EP1572962.
JD343186 - Sequence 324210 from Patent EP1572962.
JD216039 - Sequence 197063 from Patent EP1572962.
JD537182 - Sequence 518206 from Patent EP1572962.
JD194296 - Sequence 175320 from Patent EP1572962.
JD159976 - Sequence 141000 from Patent EP1572962.
JD276511 - Sequence 257535 from Patent EP1572962.
JD201117 - Sequence 182141 from Patent EP1572962.
JD519181 - Sequence 500205 from Patent EP1572962.
JD347485 - Sequence 328509 from Patent EP1572962.
JD468937 - Sequence 449961 from Patent EP1572962.
JD308029 - Sequence 289053 from Patent EP1572962.
JD095558 - Sequence 76582 from Patent EP1572962.
JD314750 - Sequence 295774 from Patent EP1572962.
JD413950 - Sequence 394974 from Patent EP1572962.
JD359909 - Sequence 340933 from Patent EP1572962.
JD492916 - Sequence 473940 from Patent EP1572962.
JD086380 - Sequence 67404 from Patent EP1572962.
JD521233 - Sequence 502257 from Patent EP1572962.
JD250341 - Sequence 231365 from Patent EP1572962.
JD322825 - Sequence 303849 from Patent EP1572962.
JD159363 - Sequence 140387 from Patent EP1572962.
JD199612 - Sequence 180636 from Patent EP1572962.
JD287263 - Sequence 268287 from Patent EP1572962.
JD562743 - Sequence 543767 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000327158.1, ENST00000327158.2, ENST00000327158.3, ENST00000327158.4, NM_013337, Q9NWI8, Q9Y584, TEX4, TIM22, TIM22_HUMAN, uc317sfj.1, uc317sfj.2
UCSC ID: ENST00000327158.5_4
RefSeq Accession: NM_013337.4
Protein: Q9Y584
(aka TIM22_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
