ID:TIMP2_HUMAN DESCRIPTION: RecName: Full=Metalloproteinase inhibitor 2; AltName: Full=CSC-21K; AltName: Full=Tissue inhibitor of metalloproteinases 2; Short=TIMP-2; Flags: Precursor; FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. SUBUNIT: Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. SUBCELLULAR LOCATION: Secreted. INDUCTION: Down-regulated by TGFB1. PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds. SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family. SIMILARITY: Contains 1 NTR domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TIMP2ID42572ch17q25.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16035
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007417 central nervous system development GO:0007568 aging GO:0008285 negative regulation of cell proliferation GO:0009725 response to hormone GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0022617 extracellular matrix disassembly GO:0032487 regulation of Rap protein signal transduction GO:0034097 response to cytokine GO:0042493 response to drug GO:0043312 neutrophil degranulation GO:0043410 positive regulation of MAPK cascade GO:0045666 positive regulation of neuron differentiation GO:0045762 positive regulation of adenylate cyclase activity GO:0045861 negative regulation of proteolysis GO:0045930 negative regulation of mitotic cell cycle GO:0046580 negative regulation of Ras protein signal transduction GO:0051045 negative regulation of membrane protein ectodomain proteolysis GO:1905049 negative regulation of metallopeptidase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
