Human Gene TJP1 (ENST00000614355.5_14) from GENCODE V47lift37
  Description: tight junction protein 1, transcript variant 5 (from RefSeq NM_001330239.4)
Gencode Transcript: ENST00000614355.5_14
Gencode Gene: ENSG00000104067.17_18
Transcript (Including UTRs)
   Position: hg19 chr15:29,992,356-30,114,671 Size: 122,316 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg19 chr15:29,993,799-30,114,231 Size: 120,433 Coding Exon Count: 28 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:29,992,356-30,114,671)mRNA (may differ from genome)Protein (1768 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TJP1
Diseases sorted by gene-association score: celiac disease (4), congenital nephrotic syndrome finnish type (2), vitreous disease (1), macular degeneration, age-related, 1 (1), night blindness, congenital stationary , 1a, x-linked (1), sciatic neuropathy (1), acute vascular insufficiency of intestine (1), usher syndrome, type 1c (1), deafness, autosomal recessive 49 (1), chandler syndrome (1), testis seminoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -250.10440-0.568 Picture PostScript Text
3' UTR -309.501443-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
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-  Descriptions from all associated GenBank mRNAs
  CR749235 - Homo sapiens mRNA; cDNA DKFZp686M05161 (from clone DKFZp686M05161).
L14837 - Human tight junction (zonula occludens) protein ZO-1 mRNA, complete cds.
BX640879 - Homo sapiens mRNA; cDNA DKFZp686A1195 (from clone DKFZp686A1195).
AB370197 - Homo sapiens TJP1 mRNA for tight junction protein ZO-1, partial cds.
BC111712 - Homo sapiens tight junction protein 1 (zona occludens 1), mRNA (cDNA clone MGC:133289 IMAGE:40037646), complete cds.
AK304758 - Homo sapiens cDNA FLJ61639 complete cds, highly similar to Tight junction protein ZO-1.
EU831947 - Synthetic construct Homo sapiens clone HAIB:100066976; DKFZo008D1223 tight junction protein 1 (zona occludens 1) protein (TJP1) gene, encodes complete protein.
EU832042 - Synthetic construct Homo sapiens clone HAIB:100067071; DKFZo004D1224 tight junction protein 1 (zona occludens 1) protein (TJP1) gene, encodes complete protein.
AB384676 - Synthetic construct DNA, clone: pF1KB0048, Homo sapiens TJP1 gene for tight junction protein ZO-1, complete cds, without stop codon, in Flexi system.
AF035298 - Homo sapiens clone 23650 mRNA sequence.
JD410371 - Sequence 391395 from Patent EP1572962.
JD289457 - Sequence 270481 from Patent EP1572962.
JD295617 - Sequence 276641 from Patent EP1572962.
JD231985 - Sequence 213009 from Patent EP1572962.
JD087779 - Sequence 68803 from Patent EP1572962.
JD233506 - Sequence 214530 from Patent EP1572962.
JD337900 - Sequence 318924 from Patent EP1572962.
JD239854 - Sequence 220878 from Patent EP1572962.
JD184283 - Sequence 165307 from Patent EP1572962.
AK302971 - Homo sapiens cDNA FLJ50931 complete cds, highly similar to Tight junction protein ZO-1.
JD141207 - Sequence 122231 from Patent EP1572962.
AK308113 - Homo sapiens cDNA, FLJ98061.
BC036090 - Homo sapiens cDNA clone IMAGE:5298040, containing frame-shift errors.
JD138732 - Sequence 119756 from Patent EP1572962.
JD296655 - Sequence 277679 from Patent EP1572962.
JD338817 - Sequence 319841 from Patent EP1572962.
JD173435 - Sequence 154459 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087X0K9, A0A087X0K9_HUMAN, ENST00000614355.1, ENST00000614355.2, ENST00000614355.3, ENST00000614355.4, hCG_27621 , NM_001330239, TJP1 , uc327per.1, uc327per.2
UCSC ID: ENST00000614355.5_14
RefSeq Accession: NM_001330239.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.