ID:KITM_HUMAN DESCRIPTION: RecName: Full=Thymidine kinase 2, mitochondrial; EC=2.7.1.21; AltName: Full=Mt-TK; Flags: Precursor; FUNCTION: Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs. CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'- phosphate. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Predominantly expressed in liver, pancreas, muscle, and brain. DISEASE: Defects in TK2 are a cause of mitochondrial DNA depletion syndrome type 2 (MTDPS2) [MIM:609560]. A disorder characterized primarily by childhood onset of muscle weakness associated with depletion of mtDNA in skeletal muscle. There is wide clinical variability; some patients have onset in infancy and show a rapidly progressive course with early death due to respiratory failure, whereas others have later onset of a slowly progressive myopathy. SIMILARITY: Belongs to the DCK/DGK family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TK2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00142
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006139 nucleobase-containing compound metabolic process GO:0009157 deoxyribonucleoside monophosphate biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0016310 phosphorylation GO:0043097 pyrimidine nucleoside salvage GO:0046092 deoxycytidine metabolic process GO:0046104 thymidine metabolic process GO:0071897 DNA biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
