ID:TLR1_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 1; AltName: Full=Toll/interleukin-1 receptor-like protein; Short=TIL; AltName: CD_antigen=CD281; Flags: Precursor; FUNCTION: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). SUBUNIT: Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. POLYMORPHISM: Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIM:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 12 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SIMILARITY: Contains 1 TIR domain. SEQUENCE CAUTION: Sequence=BAA02801.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15399
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP895496 - Sequence 360 from Patent EP3253886. D13637 - Homo sapiens KIAA0012 mRNA. BC089403 - Homo sapiens toll-like receptor 1, mRNA (cDNA clone MGC:104956 IMAGE:3063206), complete cds. AL050262 - Homo sapiens mRNA; cDNA DKFZp564I0682 (from clone DKFZp564I0682). CR533562 - Homo sapiens full open reading frame cDNA clone RZPDo834F1121D for gene TLR1, toll-like receptor 1; complete cds, incl. stopcodon. BC109093 - Homo sapiens toll-like receptor 1, mRNA (cDNA clone MGC:126311 IMAGE:40034681), complete cds. BC109094 - Homo sapiens toll-like receptor 1, mRNA (cDNA clone MGC:126312 IMAGE:40034683), complete cds. AK292982 - Homo sapiens cDNA FLJ78624 complete cds, highly similar to Homo sapiens toll-like receptor 1 (TLR1), mRNA. AB445617 - Homo sapiens TLR1 mRNA for toll-like receptor 1, complete cds. DQ012254 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-1 allele, complete cds. DQ012255 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-2 allele, complete cds. DQ012256 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-3 allele, complete cds. DQ012257 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-4 allele, complete cds. DQ012258 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-5 allele, complete cds. DQ012259 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-6 allele, complete cds. DQ012260 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-7 allele, complete cds. DQ012261 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-8 allele, complete cds. DQ012262 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-9 allele, complete cds. DQ012263 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-10 allele, complete cds. DQ012264 - Homo sapiens toll-like receptor 1 (TLR1) mRNA, TLR1-11 allele, complete cds. U88540 - Homo sapiens Toll-like receptor 1 (TLR1) mRNA, complete cds. KJ892284 - Synthetic construct Homo sapiens clone ccsbBroadEn_01678 TLR1 gene, encodes complete protein. KJ897679 - Synthetic construct Homo sapiens clone ccsbBroadEn_07073 TLR1 gene, encodes complete protein. KR711988 - Synthetic construct Homo sapiens clone CCSBHm_00034502 TLR1 (TLR1) mRNA, encodes complete protein. KR711989 - Synthetic construct Homo sapiens clone CCSBHm_00034503 TLR1 (TLR1) mRNA, encodes complete protein. KR711990 - Synthetic construct Homo sapiens clone CCSBHm_00034504 TLR1 (TLR1) mRNA, encodes complete protein. AB463313 - Synthetic construct DNA, clone: pF1KA0012, Homo sapiens TLR1 gene for toll-like receptor 1, without stop codon, in Flexi system. JD038831 - Sequence 19855 from Patent EP1572962. JD501772 - Sequence 482796 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15399 (Reactome details) participates in the following event(s):
R-HSA-168951 TLR1:TLR2 is recruited to ligand:CD14 R-HSA-1974676 Beta defensin 103 activates TLR1:TLR2 R-HSA-5432814 SFTPA/SFTPD binds TLR2:TLR1 R-HSA-2201316 Activated TLR2/4 interacts with MAL(TIRAP) R-HSA-166072 MyD88 forms a complex with MAL:activated TLR2/4 R-HSA-2201322 MAL is phosphorylated by BTK R-HSA-2559414 Activated TLR2/4:MAL interacts with BTK R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:Mal:MyD88 R-HSA-166082 IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex R-HSA-166362 Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-166286 Multiple IRAK1 autophosphorylation steps R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166363 TRAF6 binds to hp- IRAK1 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex R-HSA-2262777 TRAF6 binds to p-IRAK2 R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-1461957 Beta defensins R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-1461973 Defensins R-HSA-168898 Toll-Like Receptors Cascades R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-6803157 Antimicrobial peptides R-HSA-168249 Innate Immune System R-HSA-5602498 MyD88 deficiency (TLR2/4) R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168256 Immune System R-HSA-5603041 IRAK4 deficiency (TLR2/4) R-HSA-5602358 Diseases associated with the TLR signaling cascade R-HSA-5260271 Diseases of Immune System R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
