Human Gene TLR10 (ENST00000308973.9_7) from GENCODE V47lift37
  Description: toll like receptor 10, transcript variant 1 (from RefSeq NM_030956.4)
Gencode Transcript: ENST00000308973.9_7
Gencode Gene: ENSG00000174123.11_9
Transcript (Including UTRs)
   Position: hg19 chr4:38,773,859-38,784,611 Size: 10,753 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr4:38,774,776-38,777,211 Size: 2,436 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:38,773,859-38,784,611)mRNA (may differ from genome)Protein (811 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TLR10_HUMAN
DESCRIPTION: RecName: Full=Toll-like receptor 10; AltName: CD_antigen=CD290; Flags: Precursor;
FUNCTION: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
SUBUNIT: Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
SIMILARITY: Belongs to the Toll-like receptor family.
SIMILARITY: Contains 15 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 TIR domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TLR10
Diseases sorted by gene-association score: theileriasis (9), tonsillitis (9), meniere's disease (8), q fever (6), melioidosis (6), bronchiolitis (6), irak4 deficiency (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.85 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 63.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -166.20638-0.261 Picture PostScript Text
3' UTR -256.10917-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR001611 - Leu-rich_rpt
IPR000157 - TIR_dom
IPR017241 - Toll-like_receptor

Pfam Domains:
PF01463 - Leucine rich repeat C-terminal domain
PF01582 - TIR domain
PF12799 - Leucine Rich repeats (2 copies)
PF13676 - TIR domain
PF13855 - Leucine rich repeat

SCOP Domains:
141571 - Pentapeptide repeat-like
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1
52200 - Toll/Interleukin receptor TIR domain
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2J67 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BXR5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity

Biological Process:
GO:0002224 toll-like receptor signaling pathway
GO:0002376 immune system process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0034166 toll-like receptor 10 signaling pathway
GO:0045087 innate immune response
GO:0050707 regulation of cytokine secretion
GO:0050729 positive regulation of inflammatory response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY358300 - Homo sapiens clone DNA47361 TLR10 (UNQ315) mRNA, complete cds.
JD239161 - Sequence 220185 from Patent EP1572962.
BC089406 - Homo sapiens toll-like receptor 10, mRNA (cDNA clone MGC:104967 IMAGE:3066588), complete cds.
AK292026 - Homo sapiens cDNA FLJ76917 complete cds, highly similar to Homo sapiens toll-like receptor 10 (TLR10), mRNA.
JD511665 - Sequence 492689 from Patent EP1572962.
JD542861 - Sequence 523885 from Patent EP1572962.
JD497769 - Sequence 478793 from Patent EP1572962.
AF296673 - Homo sapiens toll-like receptor 10 mRNA, complete cds.
JD089813 - Sequence 70837 from Patent EP1572962.
BC109111 - Homo sapiens toll-like receptor 10, mRNA (cDNA clone MGC:126398 IMAGE:40035401), complete cds.
BC109112 - Homo sapiens toll-like receptor 10, mRNA (cDNA clone MGC:126399 IMAGE:40035404), complete cds.
AB445680 - Homo sapiens TLR10 mRNA for toll-like receptor 10, complete cds.
DQ011502 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-1 allele, complete cds.
DQ011503 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-2 allele, complete cds.
DQ011504 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-3 allele, complete cds.
DQ011505 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-4 allele, complete cds.
DQ011506 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-5 allele, complete cds.
DQ011507 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-6 allele, complete cds.
DQ011508 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-7 allele, complete cds.
DQ011509 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-8 allele, complete cds.
DQ011510 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-9 allele, complete cds.
DQ011511 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-10 allele, complete cds.
DQ011512 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-11 allele, complete cds.
DQ011513 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-12 allele, complete cds.
DQ011514 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-13 allele, complete cds.
DQ011515 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-14 allele, complete cds.
DQ011516 - Homo sapiens TLR10 (TLR10) mRNA, TLR10-15 allele, complete cds.
AK313468 - Homo sapiens cDNA, FLJ94015.
KJ894859 - Synthetic construct Homo sapiens clone ccsbBroadEn_04253 TLR10 gene, encodes complete protein.
KJ899692 - Synthetic construct Homo sapiens clone ccsbBroadEn_09086 TLR10 gene, encodes complete protein.
KR711987 - Synthetic construct Homo sapiens clone CCSBHm_00034491 TLR10 (TLR10) mRNA, encodes complete protein.
JD302816 - Sequence 283840 from Patent EP1572962.
JD372243 - Sequence 353267 from Patent EP1572962.
JD225154 - Sequence 206178 from Patent EP1572962.
JD511212 - Sequence 492236 from Patent EP1572962.
JD549002 - Sequence 530026 from Patent EP1572962.
JD302313 - Sequence 283337 from Patent EP1572962.
JD043055 - Sequence 24079 from Patent EP1572962.
JD133704 - Sequence 114728 from Patent EP1572962.
JD275271 - Sequence 256295 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BXR5 (Reactome details) participates in the following event(s):

R-HSA-975866 MyD88 forms a complex with the activated TLR receptor
R-HSA-975880 MyD88 oligomerization within the complex of activated TLR:MyD88
R-HSA-975873 IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
R-HSA-975852 IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
R-HSA-975865 IRAK4 autophosphorylation within the complex activated TLR:MyD88
R-HSA-975879 Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
R-HSA-975861 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
R-HSA-975878 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR
R-HSA-975874 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex
R-HSA-975853 Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR
R-HSA-975857 TRAF6 binds to hp- IRAK1 or p-IRAK2
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-168249 Innate Immune System
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-168256 Immune System
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-5260271 Diseases of Immune System
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7L1, B3Y668, D1CS21, D1CS22, ENST00000308973.1, ENST00000308973.2, ENST00000308973.3, ENST00000308973.4, ENST00000308973.5, ENST00000308973.6, ENST00000308973.7, ENST00000308973.8, NM_030956, Q32MI7, Q32MI8, Q5FWG4, Q6UXL3, Q9BXR5, TLR10_HUMAN, uc317okq.1, uc317okq.2, UNQ315/PRO358
UCSC ID: ENST00000308973.9_7
RefSeq Accession: NM_030956.4
Protein: Q9BXR5 (aka TLR10_HUMAN or TLRA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.