ID:TLR5_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 5; AltName: Full=Toll/interleukin-1 receptor-like protein 3; Flags: Precursor; FUNCTION: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. SUBUNIT: Binds MYD88 via their respective TIR domains (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis. PTM: Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines. POLYMORPHISM: Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus. DISEASE: Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1) [MIM:601744]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 15 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 TIR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60602
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP895189 - Sequence 53 from Patent EP3253886. U88881 - Homo sapiens Toll-like receptor 5 (TLR5) mRNA, partial cds. AB060695 - Homo sapiens TLR5 mRNA for Toll-like receptor 5, complete cds. AF051151 - Homo sapiens Toll/interleukin-1 receptor-like protein 3 (TIL3) mRNA, complete cds. BC109118 - Homo sapiens toll-like receptor 5, mRNA (cDNA clone MGC:126430 IMAGE:40035617), complete cds. BC109119 - Homo sapiens toll-like receptor 5, mRNA (cDNA clone MGC:126431 IMAGE:40035618), complete cds. JD507901 - Sequence 488925 from Patent EP1572962. AB445645 - Homo sapiens TLR5 mRNA for toll-like receptor 5, complete cds. KJ897681 - Synthetic construct Homo sapiens clone ccsbBroadEn_07075 TLR5 gene, encodes complete protein. JD152795 - Sequence 133819 from Patent EP1572962. JD562570 - Sequence 543594 from Patent EP1572962. JD509724 - Sequence 490748 from Patent EP1572962. JD145184 - Sequence 126208 from Patent EP1572962. JD524970 - Sequence 505994 from Patent EP1572962. JD183510 - Sequence 164534 from Patent EP1572962. JD309220 - Sequence 290244 from Patent EP1572962. JD518625 - Sequence 499649 from Patent EP1572962. JD318910 - Sequence 299934 from Patent EP1572962. JD420629 - Sequence 401653 from Patent EP1572962. JD479417 - Sequence 460441 from Patent EP1572962. JD407809 - Sequence 388833 from Patent EP1572962. JD256894 - Sequence 237918 from Patent EP1572962. JD258879 - Sequence 239903 from Patent EP1572962. JD353172 - Sequence 334196 from Patent EP1572962. JD128697 - Sequence 109721 from Patent EP1572962. JD422343 - Sequence 403367 from Patent EP1572962. JD419390 - Sequence 400414 from Patent EP1572962. JD325724 - Sequence 306748 from Patent EP1572962. JD388804 - Sequence 369828 from Patent EP1572962. JD413627 - Sequence 394651 from Patent EP1572962. JD270510 - Sequence 251534 from Patent EP1572962. JD457393 - Sequence 438417 from Patent EP1572962. JD457394 - Sequence 438418 from Patent EP1572962. JD405614 - Sequence 386638 from Patent EP1572962. JD405613 - Sequence 386637 from Patent EP1572962. JD271272 - Sequence 252296 from Patent EP1572962. JD422342 - Sequence 403366 from Patent EP1572962. JD419389 - Sequence 400413 from Patent EP1572962. JD395390 - Sequence 376414 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60602 (Reactome details) participates in the following event(s):
R-HSA-188025 Flagellin binds to TLR5 R-HSA-975866 MyD88 forms a complex with the activated TLR receptor R-HSA-975880 MyD88 oligomerization within the complex of activated TLR:MyD88 R-HSA-975873 IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor R-HSA-975852 IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex R-HSA-975865 IRAK4 autophosphorylation within the complex activated TLR:MyD88 R-HSA-975879 Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex R-HSA-975861 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex R-HSA-975878 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR R-HSA-975874 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex R-HSA-975853 Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR R-HSA-975857 TRAF6 binds to hp- IRAK1 or p-IRAK2 R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-5602680 MyD88 deficiency (TLR5) R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-168249 Innate Immune System R-HSA-5602358 Diseases associated with the TLR signaling cascade R-HSA-5603037 IRAK4 deficiency (TLR5) R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168256 Immune System R-HSA-5260271 Diseases of Immune System R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
