Human Gene TMC7 (ENST00000304381.10_11) from GENCODE V47lift37

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Description: transmembrane channel like 7, transcript variant 7 (from RefSeq NR_136733.1)
Gencode Transcript: ENST00000304381.10_11
Gencode Gene: ENSG00000170537.13_13
Transcript (Including UTRs)
Position: hg19 chr16:18,995,256-19,075,264 Size: 80,009 Total Exon Count: 16 Strand: +
Coding Region
Position: hg19 chr16:18,995,386-19,073,165 Size: 77,780 Coding Exon Count: 16

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr16:18,995,256-19,075,264)			mRNA (may differ from genome)		Protein (723 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TMC7_HUMAN DESCRIPTION: RecName: Full=Transmembrane channel-like protein 7; FUNCTION: May function as ion channels, transporters, or modulators of such. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the TMC family. SEQUENCE CAUTION: Sequence=BAB15032.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D013749 Tetrachlorodibenzodioxin C023514 2,6-dinitrotoluene C028451 3,4,3',4'-tetrachlorobiphenyl C009505 4,4'-diaminodiphenylmethane D016604 Aflatoxin B1 D000393 Air Pollutants D002737 Chloroprene D002922 Ciguatoxins more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.45 RPKM in Testis Total median expression: 65.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-66.40	130	-0.511	Picture	PostScript	Text
3' UTR	-586.80	2099	-0.280	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012496 - TMC

Pfam Domains:
PF07810 - TMC domain

ModBase Predicted Comparative 3D Structure on Q7Z402


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0006811 ion transport Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK094664 - Homo sapiens cDNA FLJ37345 fis, clone BRAMY2021142, highly similar to Homo sapiens transmembrane channel-like 7 (TMC7), mRNA. AY236498 - Homo sapiens transmembrane channel-like protein 7 (TMC7) mRNA, complete cds. BC047719 - Homo sapiens transmembrane channel-like 7, mRNA (cDNA clone MGC:52105 IMAGE:5743899), complete cds. AY263165 - Homo sapiens TMC7 protein (TMC7) mRNA, complete cds. BC036205 - Homo sapiens transmembrane channel-like 7, mRNA (cDNA clone MGC:39608 IMAGE:5261157), complete cds. AK293874 - Homo sapiens cDNA FLJ60454 complete cds, highly similar to Homo sapiens transmembrane channel-like 7 (TMC7), mRNA. CU690480 - Synthetic construct Homo sapiens gateway clone IMAGE:100021528 5' read TMC7 mRNA. KJ899589 - Synthetic construct Homo sapiens clone ccsbBroadEn_08983 TMC7 gene, encodes complete protein. CR933669 - Homo sapiens mRNA; cDNA DKFZp781O2274 (from clone DKFZp781O2274). JC506674 - Sequence 42 from Patent EP2733220. JC737786 - Sequence 42 from Patent WO2014075939. JC506688 - Sequence 56 from Patent EP2733220. JC737800 - Sequence 56 from Patent WO2014075939. AK024893 - Homo sapiens cDNA: FLJ21240 fis, clone COL01132. JD267675 - Sequence 248699 from Patent EP1572962. JD276314 - Sequence 257338 from Patent EP1572962. JD358191 - Sequence 339215 from Patent EP1572962. JD532556 - Sequence 513580 from Patent EP1572962. JD550795 - Sequence 531819 from Patent EP1572962. JD104796 - Sequence 85820 from Patent EP1572962. JD346085 - Sequence 327109 from Patent EP1572962. JD284964 - Sequence 265988 from Patent EP1572962. JD296812 - Sequence 277836 from Patent EP1572962. JD413487 - Sequence 394511 from Patent EP1572962. JD482029 - Sequence 463053 from Patent EP1572962. JD286621 - Sequence 267645 from Patent EP1572962. JD286622 - Sequence 267646 from Patent EP1572962. JD043108 - Sequence 24132 from Patent EP1572962. JD043109 - Sequence 24133 from Patent EP1572962. JD329107 - Sequence 310131 from Patent EP1572962. JD319314 - Sequence 300338 from Patent EP1572962. JD105348 - Sequence 86372 from Patent EP1572962. JD283281 - Sequence 264305 from Patent EP1572962. JD274669 - Sequence 255693 from Patent EP1572962. JD473564 - Sequence 454588 from Patent EP1572962. JD052714 - Sequence 33738 from Patent EP1572962. JD194611 - Sequence 175635 from Patent EP1572962. JD517424 - Sequence 498448 from Patent EP1572962. JD501816 - Sequence 482840 from Patent EP1572962. JD348785 - Sequence 329809 from Patent EP1572962. JD087341 - Sequence 68365 from Patent EP1572962. JD327812 - Sequence 308836 from Patent EP1572962. JD433091 - Sequence 414115 from Patent EP1572962. JD258953 - Sequence 239977 from Patent EP1572962. JD246496 - Sequence 227520 from Patent EP1572962. JD419765 - Sequence 400789 from Patent EP1572962. JD419766 - Sequence 400790 from Patent EP1572962. JD089501 - Sequence 70525 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: E7ERB6, ENST00000304381.1, ENST00000304381.2, ENST00000304381.3, ENST00000304381.4, ENST00000304381.5, ENST00000304381.6, ENST00000304381.7, ENST00000304381.8, ENST00000304381.9, NR_136733, Q5H9Q8, Q7Z402, Q7Z5M4, Q86WX0, Q9H766, TMC7_HUMAN, uc317nkl.1, uc317nkl.2 UCSC ID: ENST00000304381.10_11 RefSeq Accession: NM_024847.4 Protein: Q7Z402 (aka TMC7_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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