ID:TMED7_HUMAN DESCRIPTION: RecName: Full=Transmembrane emp24 domain-containing protein 7; AltName: Full=p24 family protein gamma-3; Short=p24gamma3; AltName: Full=p27; Flags: Precursor; FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications. SUBUNIT: Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory pathway. PTM: N-linked glycosylated in complex form containing terminal sialic acid. SIMILARITY: Belongs to the EMP24/GP25L family. SIMILARITY: Contains 1 GOLD domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 101576 - Supernatant protein factor (SPF), C-terminal domain
ModBase Predicted Comparative 3D Structure on Q9Y3B3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0015031 protein transport
BC064944 - Homo sapiens cDNA clone IMAGE:6018003, **** WARNING: chimeric clone ****. AY304583 - Homo sapiens TIRAP3a (TIRAP3) mRNA, complete cds. AY304584 - Homo sapiens TIRAP3b (TIRAP3) mRNA, complete cds. AY275836 - Homo sapiens TIR domain-containing adapter protein mRNA, complete cds. AK075218 - Homo sapiens cDNA FLJ90737 fis, clone PLACE1010827, moderately similar to Membrane protein p24B precursor. AY304581 - Homo sapiens TIRAP3b long form (TIRAP3) mRNA, complete cds. AF151867 - Homo sapiens CGI-109 protein mRNA, complete cds. AK074962 - Homo sapiens cDNA FLJ90481 fis, clone NT2RP3002900, moderately similar to Membrane protein p24B precursor. AB002451 - Homo sapiens mRNA, clone: A3-B, from chromosome 5q21-q22. JD093445 - Sequence 74469 from Patent EP1572962. JD248324 - Sequence 229348 from Patent EP1572962. JD557116 - Sequence 538140 from Patent EP1572962. JD232024 - Sequence 213048 from Patent EP1572962. JD527352 - Sequence 508376 from Patent EP1572962. JD298659 - Sequence 279683 from Patent EP1572962. JD362775 - Sequence 343799 from Patent EP1572962. JD320180 - Sequence 301204 from Patent EP1572962. JD348361 - Sequence 329385 from Patent EP1572962. JD308724 - Sequence 289748 from Patent EP1572962. BC019349 - Homo sapiens transmembrane emp24 protein transport domain containing 7, mRNA (cDNA clone MGC:13042 IMAGE:3625342), complete cds. BC107426 - Homo sapiens transmembrane emp24 protein transport domain containing 7, mRNA (cDNA clone IMAGE:4770522), partial cds. AB002450 - Homo sapiens mRNA, clone: A3-A, from chromosome 5q21-q22. JD355350 - Sequence 336374 from Patent EP1572962. JD455843 - Sequence 436867 from Patent EP1572962. JD212068 - Sequence 193092 from Patent EP1572962. JD303197 - Sequence 284221 from Patent EP1572962. AK027512 - Homo sapiens cDNA FLJ14606 fis, clone NT2RP1000547, weakly similar to COP-COATED VESICLE MEMBRANE PROTEIN P24 PRECURSOR. JD244775 - Sequence 225799 from Patent EP1572962. JD288566 - Sequence 269590 from Patent EP1572962. AK304210 - Homo sapiens cDNA FLJ57776 complete cds, highly similar to Transmembrane emp24 domain-containing protein 7 precursor. JD280133 - Sequence 261157 from Patent EP1572962. JD292063 - Sequence 273087 from Patent EP1572962. HQ447119 - Synthetic construct Homo sapiens clone IMAGE:100070406; CCSB006255_01 transmembrane emp24 protein transport domain containing 7 (TMED7) gene, encodes complete protein. KJ893779 - Synthetic construct Homo sapiens clone ccsbBroadEn_03173 TMED7 gene, encodes complete protein. CU676434 - Synthetic construct Homo sapiens gateway clone IMAGE:100016810 5' read TMED7 mRNA. JD318231 - Sequence 299255 from Patent EP1572962. JD048153 - Sequence 29177 from Patent EP1572962. JD386756 - Sequence 367780 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y3B3 (Reactome details) participates in the following event(s):
R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
