Human Gene TMEM102 (ENST00000323206.2_4) from GENCODE V47lift37
  Description: transmembrane protein 102, transcript variant 2 (from RefSeq NM_178518.3)
Gencode Transcript: ENST00000323206.2_4
Gencode Gene: ENSG00000181284.3_8
Transcript (Including UTRs)
   Position: hg19 chr17:7,338,754-7,340,998 Size: 2,245 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr17:7,339,191-7,340,825 Size: 1,635 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:7,338,754-7,340,998)mRNA (may differ from genome)Protein (508 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM102_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 102; AltName: Full=Common beta-chain associated protein; Short=CBAP;
FUNCTION: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.
SUBUNIT: Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.
SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. Note=Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.10 RPKM in Testis
Total median expression: 111.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.40281-0.361 Picture PostScript Text
3' UTR -68.30173-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020950 - Mab-21-rel
IPR024810 - Mab-21_dom
IPR024806 - TMEM102

Pfam Domains:
PF03281 - Mab-21 protein

ModBase Predicted Comparative 3D Structure on Q8N9M5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0010820 positive regulation of T cell chemotaxis
GO:0034097 response to cytokine
GO:0042981 regulation of apoptotic process
GO:0045785 positive regulation of cell adhesion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000406 positive regulation of T cell migration

Cellular Component:
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  LF209149 - JP 2014500723-A/16652: Polycomb-Associated Non-Coding RNAs.
LF212405 - JP 2014500723-A/19908: Polycomb-Associated Non-Coding RNAs.
LF209148 - JP 2014500723-A/16651: Polycomb-Associated Non-Coding RNAs.
BC046189 - Homo sapiens transmembrane protein 102, mRNA (cDNA clone MGC:57791 IMAGE:5730428), complete cds.
AK094197 - Homo sapiens cDNA FLJ36878 fis, clone BGGI11000024.
KJ895980 - Synthetic construct Homo sapiens clone ccsbBroadEn_05374 TMEM102 gene, encodes complete protein.
MA444726 - JP 2018138019-A/16652: Polycomb-Associated Non-Coding RNAs.
MA447982 - JP 2018138019-A/19908: Polycomb-Associated Non-Coding RNAs.
MA444725 - JP 2018138019-A/16651: Polycomb-Associated Non-Coding RNAs.
JD454546 - Sequence 435570 from Patent EP1572962.
JD347917 - Sequence 328941 from Patent EP1572962.
JD459693 - Sequence 440717 from Patent EP1572962.
JD459694 - Sequence 440718 from Patent EP1572962.
JD128551 - Sequence 109575 from Patent EP1572962.
LF213227 - JP 2014500723-A/20730: Polycomb-Associated Non-Coding RNAs.
LF326432 - JP 2014500723-A/133935: Polycomb-Associated Non-Coding RNAs.
MA562009 - JP 2018138019-A/133935: Polycomb-Associated Non-Coding RNAs.
MA448804 - JP 2018138019-A/20730: Polycomb-Associated Non-Coding RNAs.
LF326431 - JP 2014500723-A/133934: Polycomb-Associated Non-Coding RNAs.
JD485553 - Sequence 466577 from Patent EP1572962.
MA562008 - JP 2018138019-A/133934: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DTP8, ENST00000323206.1, NM_178518, Q8N9M5, TM102_HUMAN, uc317rkq.1, uc317rkq.2
UCSC ID: ENST00000323206.2_4
RefSeq Accession: NM_178518.3
Protein: Q8N9M5 (aka TM102_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.