Human Gene TMEM139 (ENST00000359333.8_4) from GENCODE V47lift37

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Description: transmembrane protein 139, transcript variant 8 (from RefSeq NM_001282876.2)
Gencode Transcript: ENST00000359333.8_4
Gencode Gene: ENSG00000178826.11_7
Transcript (Including UTRs)
Position: hg19 chr7:142,982,051-142,985,141 Size: 3,091 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr7:142,983,051-142,983,922 Size: 872 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:142,982,051-142,985,141)			mRNA (may differ from genome)		Protein (216 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TM139_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 139; Flags: Precursor; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). SEQUENCE CAUTION: Sequence=AAH16719.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C006253 pirinixic acid C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D019327 Copper Sulfate D004237 Diuron D004958 Estradiol D019833 Genistein D011794 Quercetin D012906 Smoke D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C006780 bisphenol A

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 15.65 RPKM in Kidney - Cortex Total median expression: 92.33 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-189.80	505	-0.376	Picture	PostScript	Text
3' UTR	-394.70	1219	-0.324	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

ModBase Predicted Comparative 3D Structure on Q8IV31


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	X74852 - H.sapiens (4.49) mRNA for T-cell receptor beta chain. MG193069 - Homo sapiens isolate HD20_NN16_C10 T cell receptor beta mRNA, partial cds. KX077150 - Homo sapiens isolate SG_Subject8 clone 1377-8 T-cell receptor beta chain variable region (TRB) mRNA, partial cds. KJ895507 - Synthetic construct Homo sapiens clone ccsbBroadEn_04901 TMEM139 gene, encodes complete protein. AB044099 - Homo sapiens mRNA for T-cell receptor beta chain, partial cds, clone:TCRVB.1. KX075225 - Homo sapiens isolate PB_Subject6 clone 1004-6 T-cell receptor beta chain variable region (TRB) mRNA, partial cds. AY190102 - Homo sapiens clone PSA.S.36 T-cell receptor beta chain mRNA, partial cds. KX074606 - Homo sapiens isolate PB_Subject7 clone 385-7 T-cell receptor beta chain variable region (TRB) mRNA, partial cds. AY006133 - Homo sapiens clone pbvb333 T cell receptor beta chain mRNA, partial cds. AY006320 - Homo sapiens clone 09npa66 T cell receptor beta chain mRNA, partial cds. AY358781 - Homo sapiens clone DNA92264 VPMH1932 (UNQ1932) mRNA, complete cds. AK315170 - Homo sapiens cDNA, FLJ96145. AK075067 - Homo sapiens cDNA FLJ90586 fis, clone PLACE1000912. AK027352 - Homo sapiens cDNA FLJ14446 fis, clone HEMBB1001302. AK172816 - Homo sapiens cDNA FLJ23977 fis, clone HEP20612. BC035517 - Homo sapiens transmembrane protein 139, mRNA (cDNA clone MGC:40196 IMAGE:5207904), complete cds. JD260160 - Sequence 241184 from Patent EP1572962. JD181388 - Sequence 162412 from Patent EP1572962. JD049868 - Sequence 30892 from Patent EP1572962. JD158569 - Sequence 139593 from Patent EP1572962. JD145508 - Sequence 126532 from Patent EP1572962. BC035888 - Homo sapiens transmembrane protein 139, mRNA (cDNA clone IMAGE:5176443). JD226767 - Sequence 207791 from Patent EP1572962. JD232965 - Sequence 213989 from Patent EP1572962. JD327570 - Sequence 308594 from Patent EP1572962. JD202574 - Sequence 183598 from Patent EP1572962. JD135117 - Sequence 116141 from Patent EP1572962. CU690100 - Synthetic construct Homo sapiens gateway clone IMAGE:100023291 5' read TMEM139 mRNA. BC048333 - Homo sapiens transmembrane protein 139, mRNA (cDNA clone IMAGE:5186802), with apparent retained intron. BC016719 - Homo sapiens transmembrane protein 139, mRNA (cDNA clone IMAGE:4070464), partial cds. JD184401 - Sequence 165425 from Patent EP1572962. JD358653 - Sequence 339677 from Patent EP1572962. JD232358 - Sequence 213382 from Patent EP1572962. JD290797 - Sequence 271821 from Patent EP1572962. JD356093 - Sequence 337117 from Patent EP1572962. JD497110 - Sequence 478134 from Patent EP1572962. JD378878 - Sequence 359902 from Patent EP1572962. JD178729 - Sequence 159753 from Patent EP1572962. JD236556 - Sequence 217580 from Patent EP1572962. JD242055 - Sequence 223079 from Patent EP1572962. JD423628 - Sequence 404652 from Patent EP1572962. JD230922 - Sequence 211946 from Patent EP1572962. JD162437 - Sequence 143461 from Patent EP1572962. JD132751 - Sequence 113775 from Patent EP1572962. JD418584 - Sequence 399608 from Patent EP1572962. JD150976 - Sequence 132000 from Patent EP1572962. JD294890 - Sequence 275914 from Patent EP1572962. JD044852 - Sequence 25876 from Patent EP1572962. JD062617 - Sequence 43641 from Patent EP1572962. JD228627 - Sequence 209651 from Patent EP1572962. JD040113 - Sequence 21137 from Patent EP1572962. JD130112 - Sequence 111136 from Patent EP1572962. JD129714 - Sequence 110738 from Patent EP1572962. JD225715 - Sequence 206739 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2RCL5, D3DXD4, ENST00000359333.1, ENST00000359333.2, ENST00000359333.3, ENST00000359333.4, ENST00000359333.5, ENST00000359333.6, ENST00000359333.7, NM_001282876, Q6ZME2, Q8IV31, Q8NC22, Q96AU8, TM139_HUMAN, uc318azz.1, uc318azz.2, UNQ1932/PRO4407 UCSC ID: ENST00000359333.8_4 RefSeq Accession: NM_001282876.2 Protein: Q8IV31 (aka TM139_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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