Human Gene TMEM14B (ENST00000379542.10_4) from GENCODE V47lift37
  Description: transmembrane protein 14B, transcript variant 1 (from RefSeq NM_030969.5)
Gencode Transcript: ENST00000379542.10_4
Gencode Gene: ENSG00000137210.14_10
Transcript (Including UTRs)
   Position: hg19 chr6:10,748,038-10,757,214 Size: 9,177 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr6:10,749,479-10,756,751 Size: 7,273 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:10,748,038-10,757,214)mRNA (may differ from genome)Protein (114 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM14B_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 14B;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the UPF0136 (TMEM14) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.87 RPKM in Adrenal Gland
Total median expression: 395.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.90121-0.379 Picture PostScript Text
3' UTR -93.30463-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005349 - UPF0136_TM

Pfam Domains:
PF03647 - Transmembrane proteins 14C

ModBase Predicted Comparative 3D Structure on Q9NUH8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0021987 cerebral cortex development
GO:0061351 neural precursor cell proliferation
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK294018 - Homo sapiens cDNA FLJ60468 complete cds, weakly similar to Synaptonemal complex protein 2.
KJ894865 - Synthetic construct Homo sapiens clone ccsbBroadEn_04259 TMEM14B gene, encodes complete protein.
KJ899695 - Synthetic construct Homo sapiens clone ccsbBroadEn_09089 TMEM14B gene, encodes complete protein.
HQ447475 - Synthetic construct Homo sapiens clone IMAGE:100070805; CCSB014338_01 transmembrane protein 14B (TMEM14B) gene, encodes complete protein.
AK311340 - Homo sapiens cDNA, FLJ18382.
BC013913 - Homo sapiens transmembrane protein 14B, mRNA (cDNA clone MGC:22692 IMAGE:3685635), complete cds.
AK294152 - Homo sapiens cDNA FLJ58456 complete cds, highly similar to Transmembrane protein 14B.
BC007080 - Homo sapiens transmembrane protein 14B, mRNA (cDNA clone MGC:14614 IMAGE:4066217), complete cds.
AK291883 - Homo sapiens cDNA FLJ76591 complete cds, highly similar to Homo sapiens transmembrane protein 14B (TMEM14B), mRNA.
JD204898 - Sequence 185922 from Patent EP1572962.
BC001033 - Homo sapiens transmembrane protein 14B, mRNA (cDNA clone MGC:1223 IMAGE:3139565), complete cds.
JD441612 - Sequence 422636 from Patent EP1572962.
BC071660 - Homo sapiens transmembrane protein 14B, mRNA (cDNA clone MGC:87853 IMAGE:4473732), complete cds.
KJ899696 - Synthetic construct Homo sapiens clone ccsbBroadEn_09090 TMEM14B gene, encodes complete protein.
KJ906345 - Synthetic construct Homo sapiens clone ccsbBroadEn_16015 TMEM14B gene, encodes complete protein.
CU687130 - Synthetic construct Homo sapiens gateway clone IMAGE:100022736 5' read TMEM14B mRNA.
JD320464 - Sequence 301488 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000379542.1, ENST00000379542.2, ENST00000379542.3, ENST00000379542.4, ENST00000379542.5, ENST00000379542.6, ENST00000379542.7, ENST00000379542.8, ENST00000379542.9, NM_030969, Q5THN7, Q5THN8, Q96IX7, Q9BVN8, Q9NUH8, TM14B_HUMAN, uc318par.1, uc318par.2
UCSC ID: ENST00000379542.10_4
RefSeq Accession: NM_030969.5
Protein: Q9NUH8 (aka TM14B_HUMAN or T14B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.