Human Gene TMEM184C (ENST00000296582.8_4) from GENCODE V47lift37
  Description: transmembrane protein 184C (from RefSeq NM_018241.3)
Gencode Transcript: ENST00000296582.8_4
Gencode Gene: ENSG00000164168.8_13
Transcript (Including UTRs)
   Position: hg19 chr4:148,538,548-148,557,872 Size: 19,325 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr4:148,539,108-148,555,585 Size: 16,478 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:148,538,548-148,557,872)mRNA (may differ from genome)Protein (438 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T184C_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 184C; AltName: Full=Transmembrane protein 34;
FUNCTION: Possible tumor suppressor which may play a role in cell growth.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.
SIMILARITY: Belongs to the TMEM184 family.
SEQUENCE CAUTION: Sequence=AAK55526.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90988.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.49 RPKM in Thyroid
Total median expression: 314.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -210.40560-0.376 Picture PostScript Text
3' UTR -482.902287-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005178 - Ost-alpha

Pfam Domains:
PF03619 - Organic solute transporter Ostalpha

ModBase Predicted Comparative 3D Structure on Q9NVA4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ902873 - Synthetic construct Homo sapiens clone ccsbBroadEn_12267 TMEM184C gene, encodes complete protein.
BC046128 - Homo sapiens transmembrane protein 184C, mRNA (cDNA clone MGC:57601 IMAGE:5750613), complete cds.
AK001708 - Homo sapiens cDNA FLJ10846 fis, clone NT2RP4001373.
JD205232 - Sequence 186256 from Patent EP1572962.
JD154920 - Sequence 135944 from Patent EP1572962.
JD460929 - Sequence 441953 from Patent EP1572962.
JD141815 - Sequence 122839 from Patent EP1572962.
JD145669 - Sequence 126693 from Patent EP1572962.
JD476370 - Sequence 457394 from Patent EP1572962.
JD151102 - Sequence 132126 from Patent EP1572962.
JD468762 - Sequence 449786 from Patent EP1572962.
JD089211 - Sequence 70235 from Patent EP1572962.
JD409454 - Sequence 390478 from Patent EP1572962.
JD227667 - Sequence 208691 from Patent EP1572962.
JD523141 - Sequence 504165 from Patent EP1572962.
JD433201 - Sequence 414225 from Patent EP1572962.
JD052778 - Sequence 33802 from Patent EP1572962.
CU692306 - Synthetic construct Homo sapiens gateway clone IMAGE:100021298 5' read TMEM34 mRNA.
AK000169 - Homo sapiens cDNA FLJ20162 fis, clone COL09280.
AF305823 - Homo sapiens PRO1355 mRNA, complete cds.
BC008120 - Homo sapiens transmembrane protein 184C, mRNA (cDNA clone IMAGE:3448856), partial cds.
JD396829 - Sequence 377853 from Patent EP1572962.
JD353193 - Sequence 334217 from Patent EP1572962.
JD353194 - Sequence 334218 from Patent EP1572962.
JD258913 - Sequence 239937 from Patent EP1572962.
JD152517 - Sequence 133541 from Patent EP1572962.
JD257248 - Sequence 238272 from Patent EP1572962.
JD409133 - Sequence 390157 from Patent EP1572962.
JD219455 - Sequence 200479 from Patent EP1572962.
JD143861 - Sequence 124885 from Patent EP1572962.
JD107641 - Sequence 88665 from Patent EP1572962.
JD143808 - Sequence 124832 from Patent EP1572962.
JD172189 - Sequence 153213 from Patent EP1572962.
JD084822 - Sequence 65846 from Patent EP1572962.
JD296523 - Sequence 277547 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DP04, ENST00000296582.1, ENST00000296582.2, ENST00000296582.3, ENST00000296582.4, ENST00000296582.5, ENST00000296582.6, ENST00000296582.7, NM_018241, PRO1355, Q86X84, Q969I7, Q9NVA4, Q9NXM2, T184C_HUMAN, TMEM34, uc317lve.1, uc317lve.2
UCSC ID: ENST00000296582.8_4
RefSeq Accession: NM_018241.3
Protein: Q9NVA4 (aka T184C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.