ID:NEPR1_HUMAN DESCRIPTION: RecName: Full=Nuclear envelope phosphatase-regulatory subunit 1; Short=NEP1-R1; AltName: Full=Transmembrane protein 188; FUNCTION: Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. SUBUNIT: Interacts with CTDNEP1; the complex dephosphorylates LPIN1 and LPIN2. INTERACTION: O95476:CTDNEP1; NbExp=4; IntAct=EBI-5323455, EBI-5323433; SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Note=Filamentous pattern in the cytoplasm. TISSUE SPECIFICITY: Muscle specific with lower expression in other metabolic tissues. SIMILARITY: Belongs to the CNEP1R1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N9A8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0007077 mitotic nuclear envelope disassembly GO:0010867 positive regulation of triglyceride biosynthetic process GO:0034504 protein localization to nucleus GO:0035307 positive regulation of protein dephosphorylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
