Human Gene TMEM192 (ENST00000306480.11_10) from GENCODE V47lift37
  Description: transmembrane protein 192 (from RefSeq NM_001100389.2)
Gencode Transcript: ENST00000306480.11_10
Gencode Gene: ENSG00000170088.14_14
Transcript (Including UTRs)
   Position: hg19 chr4:165,991,760-166,034,012 Size: 42,253 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr4:166,000,810-166,033,925 Size: 33,116 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:165,991,760-166,034,012)mRNA (may differ from genome)Protein (271 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM192_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 192;
SUBUNIT: Homodimer (Probable).
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein. Late endosome.
TISSUE SPECIFICITY: Strongly expressed in kidney, liver, lung and pancreas.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
PTM: Not N-glycosylated.
SIMILARITY: Belongs to the TMEM192 family.
SEQUENCE CAUTION: Sequence=CAD97974.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.52 RPKM in Ovary
Total median expression: 162.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.1087-0.426 Picture PostScript Text
3' UTR -3604.109050-0.398 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14802 - TMEM192 family

ModBase Predicted Comparative 3D Structure on Q8IY95
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042803 protein homodimerization activity

Cellular Component:
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AK095801 - Homo sapiens cDNA FLJ38482 fis, clone FEBRA2022963.
JD369221 - Sequence 350245 from Patent EP1572962.
JD384766 - Sequence 365790 from Patent EP1572962.
JD461766 - Sequence 442790 from Patent EP1572962.
JD543457 - Sequence 524481 from Patent EP1572962.
JD140152 - Sequence 121176 from Patent EP1572962.
JD543456 - Sequence 524480 from Patent EP1572962.
JD543458 - Sequence 524482 from Patent EP1572962.
JD543454 - Sequence 524478 from Patent EP1572962.
JD376116 - Sequence 357140 from Patent EP1572962.
JD497865 - Sequence 478889 from Patent EP1572962.
JD497866 - Sequence 478890 from Patent EP1572962.
JD112440 - Sequence 93464 from Patent EP1572962.
JD089541 - Sequence 70565 from Patent EP1572962.
JD330999 - Sequence 312023 from Patent EP1572962.
JD242708 - Sequence 223732 from Patent EP1572962.
JD182844 - Sequence 163868 from Patent EP1572962.
JD333384 - Sequence 314408 from Patent EP1572962.
JD144733 - Sequence 125757 from Patent EP1572962.
JD320266 - Sequence 301290 from Patent EP1572962.
JD101955 - Sequence 82979 from Patent EP1572962.
JD481409 - Sequence 462433 from Patent EP1572962.
JD370235 - Sequence 351259 from Patent EP1572962.
JD246826 - Sequence 227850 from Patent EP1572962.
JD413329 - Sequence 394353 from Patent EP1572962.
JD246824 - Sequence 227848 from Patent EP1572962.
JD528944 - Sequence 509968 from Patent EP1572962.
JD430073 - Sequence 411097 from Patent EP1572962.
JD098870 - Sequence 79894 from Patent EP1572962.
JD404892 - Sequence 385916 from Patent EP1572962.
JD376140 - Sequence 357164 from Patent EP1572962.
JD376139 - Sequence 357163 from Patent EP1572962.
JD454132 - Sequence 435156 from Patent EP1572962.
JD180026 - Sequence 161050 from Patent EP1572962.
JD413176 - Sequence 394200 from Patent EP1572962.
JD225795 - Sequence 206819 from Patent EP1572962.
BX538029 - Homo sapiens mRNA; cDNA DKFZp686K0275 (from clone DKFZp686K0275); complete cds.
JD452780 - Sequence 433804 from Patent EP1572962.
JD373176 - Sequence 354200 from Patent EP1572962.
JD249942 - Sequence 230966 from Patent EP1572962.
BC036301 - Homo sapiens transmembrane protein 192, mRNA (cDNA clone MGC:24936 IMAGE:4778254), complete cds.
JD238793 - Sequence 219817 from Patent EP1572962.
JD312772 - Sequence 293796 from Patent EP1572962.
JD056085 - Sequence 37109 from Patent EP1572962.
JD063373 - Sequence 44397 from Patent EP1572962.
JD238285 - Sequence 219309 from Patent EP1572962.
JD243154 - Sequence 224178 from Patent EP1572962.
JD473863 - Sequence 454887 from Patent EP1572962.
JD136092 - Sequence 117116 from Patent EP1572962.
JD083150 - Sequence 64174 from Patent EP1572962.
BX648915 - Homo sapiens mRNA; cDNA DKFZp686D06272 (from clone DKFZp686D06272).
JD082841 - Sequence 63865 from Patent EP1572962.
JD359067 - Sequence 340091 from Patent EP1572962.
CU690322 - Synthetic construct Homo sapiens gateway clone IMAGE:100016940 5' read FLJ38482 mRNA.
HQ447103 - Synthetic construct Homo sapiens clone IMAGE:100070388; CCSB008064_01 hypothetical protein FLJ38482 (TMEM192) gene, encodes complete protein.
KJ895807 - Synthetic construct Homo sapiens clone ccsbBroadEn_05201 TMEM192 gene, encodes complete protein.
JD218651 - Sequence 199675 from Patent EP1572962.
JD368913 - Sequence 349937 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000306480.1, ENST00000306480.10, ENST00000306480.2, ENST00000306480.3, ENST00000306480.4, ENST00000306480.5, ENST00000306480.6, ENST00000306480.7, ENST00000306480.8, ENST00000306480.9, NM_001100389, Q7Z3A1, Q8IY95, Q8N928, TM192_HUMAN, uc317nwa.1, uc317nwa.2
UCSC ID: ENST00000306480.11_10
RefSeq Accession: NM_001100389.2
Protein: Q8IY95 (aka TM192_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.