Human Gene CEMIP2 (ENST00000377044.9_10) from GENCODE V47lift37
  Description: cell migration inducing hyaluronidase 2, transcript variant 1 (from RefSeq NM_013390.3)
Gencode Transcript: ENST00000377044.9_10
Gencode Gene: ENSG00000135048.14_13
Transcript (Including UTRs)
   Position: hg19 chr9:74,298,282-74,383,429 Size: 85,148 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr9:74,300,113-74,365,289 Size: 65,177 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:74,298,282-74,383,429)mRNA (may differ from genome)Protein (1383 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMEM2_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 2;
FUNCTION: May be required for the heart morphogenesis (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the TMEM2 family.
SIMILARITY: Contains 1 G8 domain.
SIMILARITY: Contains 3 PbH1 repeats.
SEQUENCE CAUTION: Sequence=BAA92650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC11574.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI15172.1; Type=Erroneous gene model prediction; Sequence=CAI15173.1; Type=Erroneous gene model prediction; Sequence=CAI15174.1; Type=Erroneous gene model prediction; Sequence=CAI15175.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.55 RPKM in Lung
Total median expression: 295.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.90169-0.378 Picture PostScript Text
3' UTR -506.701831-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019316 - G8_domain
IPR011050 - Pectin_lyase_fold/virulence

Pfam Domains:
PF10162 - G8 domain
PF15711 - Interleukin-like EMT inducer

SCOP Domains:
51126 - Pectin lyase-like

ModBase Predicted Comparative 3D Structure on Q9UHN6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004415 hyalurononglucosaminidase activity
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0045296 cadherin binding

Biological Process:
GO:0001525 angiogenesis
GO:0007275 multicellular organism development
GO:0008152 metabolic process
GO:0030214 hyaluronan catabolic process
GO:1903670 regulation of sprouting angiogenesis

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF211277 - JP 2014500723-A/18780: Polycomb-Associated Non-Coding RNAs.
AK075370 - Homo sapiens cDNA PSEC0058 fis, clone NT2RP2000636.
AF137030 - Homo sapiens transmembrane protein 2 (TMEM2) mRNA, complete cds.
AB037833 - Homo sapiens KIAA1412 mRNA for KIAA1412 protein.
BC146780 - Homo sapiens transmembrane protein 2, mRNA (cDNA clone MGC:166863 IMAGE:9007233), complete cds.
BC140773 - Homo sapiens transmembrane protein 2, mRNA (cDNA clone MGC:176450 IMAGE:9021641), complete cds.
BC144510 - Homo sapiens cDNA clone IMAGE:9053037.
BC171782 - Homo sapiens cDNA clone IMAGE:9054436.
AK300405 - Homo sapiens cDNA FLJ61402 complete cds, highly similar to Homo sapiens transmembrane protein 2 (TMEM2), mRNA.
AK303765 - Homo sapiens cDNA FLJ55828 complete cds, highly similar to Homo sapiens transmembrane protein 2 (TMEM2), mRNA.
AB384202 - Synthetic construct DNA, clone: pF1KSDA1412, Homo sapiens TMEM2 gene for transmembrane protein 2, complete cds, without stop codon, in Flexi system.
KJ898531 - Synthetic construct Homo sapiens clone ccsbBroadEn_07925 TMEM2 gene, encodes complete protein.
MA446854 - JP 2018138019-A/18780: Polycomb-Associated Non-Coding RNAs.
AK027818 - Homo sapiens cDNA FLJ14912 fis, clone PLACE1006492, highly similar to Homo sapiens transmembrane protein 2 (TMEM2), mRNA.
JD073150 - Sequence 54174 from Patent EP1572962.
JD233452 - Sequence 214476 from Patent EP1572962.
BC044850 - Homo sapiens cDNA clone IMAGE:4822607.
LF345216 - JP 2014500723-A/152719: Polycomb-Associated Non-Coding RNAs.
JD240560 - Sequence 221584 from Patent EP1572962.
JD311573 - Sequence 292597 from Patent EP1572962.
JD411033 - Sequence 392057 from Patent EP1572962.
JD518369 - Sequence 499393 from Patent EP1572962.
JD482546 - Sequence 463570 from Patent EP1572962.
JD232204 - Sequence 213228 from Patent EP1572962.
LF345215 - JP 2014500723-A/152718: Polycomb-Associated Non-Coding RNAs.
JD455175 - Sequence 436199 from Patent EP1572962.
JD440715 - Sequence 421739 from Patent EP1572962.
JD549643 - Sequence 530667 from Patent EP1572962.
JD391874 - Sequence 372898 from Patent EP1572962.
JD311095 - Sequence 292119 from Patent EP1572962.
JD327007 - Sequence 308031 from Patent EP1572962.
JD320543 - Sequence 301567 from Patent EP1572962.
JD315762 - Sequence 296786 from Patent EP1572962.
LF345214 - JP 2014500723-A/152717: Polycomb-Associated Non-Coding RNAs.
JD106272 - Sequence 87296 from Patent EP1572962.
JD134298 - Sequence 115322 from Patent EP1572962.
JD206355 - Sequence 187379 from Patent EP1572962.
JD363515 - Sequence 344539 from Patent EP1572962.
JD301053 - Sequence 282077 from Patent EP1572962.
JD295630 - Sequence 276654 from Patent EP1572962.
JD201684 - Sequence 182708 from Patent EP1572962.
LF345213 - JP 2014500723-A/152716: Polycomb-Associated Non-Coding RNAs.
JD173804 - Sequence 154828 from Patent EP1572962.
LF345212 - JP 2014500723-A/152715: Polycomb-Associated Non-Coding RNAs.
LF345210 - JP 2014500723-A/152713: Polycomb-Associated Non-Coding RNAs.
LF345207 - JP 2014500723-A/152710: Polycomb-Associated Non-Coding RNAs.
MA580793 - JP 2018138019-A/152719: Polycomb-Associated Non-Coding RNAs.
MA580792 - JP 2018138019-A/152718: Polycomb-Associated Non-Coding RNAs.
MA580791 - JP 2018138019-A/152717: Polycomb-Associated Non-Coding RNAs.
MA580790 - JP 2018138019-A/152716: Polycomb-Associated Non-Coding RNAs.
MA580789 - JP 2018138019-A/152715: Polycomb-Associated Non-Coding RNAs.
MA580787 - JP 2018138019-A/152713: Polycomb-Associated Non-Coding RNAs.
MA580784 - JP 2018138019-A/152710: Polycomb-Associated Non-Coding RNAs.
LF211278 - JP 2014500723-A/18781: Polycomb-Associated Non-Coding RNAs.
LF345202 - JP 2014500723-A/152705: Polycomb-Associated Non-Coding RNAs.
LF345201 - JP 2014500723-A/152704: Polycomb-Associated Non-Coding RNAs.
LF345199 - JP 2014500723-A/152702: Polycomb-Associated Non-Coding RNAs.
LF345196 - JP 2014500723-A/152699: Polycomb-Associated Non-Coding RNAs.
LF345195 - JP 2014500723-A/152698: Polycomb-Associated Non-Coding RNAs.
LF345194 - JP 2014500723-A/152697: Polycomb-Associated Non-Coding RNAs.
LF345190 - JP 2014500723-A/152693: Polycomb-Associated Non-Coding RNAs.
LF345189 - JP 2014500723-A/152692: Polycomb-Associated Non-Coding RNAs.
LF345187 - JP 2014500723-A/152690: Polycomb-Associated Non-Coding RNAs.
LF345186 - JP 2014500723-A/152689: Polycomb-Associated Non-Coding RNAs.
LF345184 - JP 2014500723-A/152687: Polycomb-Associated Non-Coding RNAs.
LF345182 - JP 2014500723-A/152685: Polycomb-Associated Non-Coding RNAs.
AK056807 - Homo sapiens cDNA FLJ32245 fis, clone PROST1000083.
JD394483 - Sequence 375507 from Patent EP1572962.
JD555856 - Sequence 536880 from Patent EP1572962.
JD522631 - Sequence 503655 from Patent EP1572962.
JD141942 - Sequence 122966 from Patent EP1572962.
MA580779 - JP 2018138019-A/152705: Polycomb-Associated Non-Coding RNAs.
MA580778 - JP 2018138019-A/152704: Polycomb-Associated Non-Coding RNAs.
MA580776 - JP 2018138019-A/152702: Polycomb-Associated Non-Coding RNAs.
MA580773 - JP 2018138019-A/152699: Polycomb-Associated Non-Coding RNAs.
MA580772 - JP 2018138019-A/152698: Polycomb-Associated Non-Coding RNAs.
MA580771 - JP 2018138019-A/152697: Polycomb-Associated Non-Coding RNAs.
MA580767 - JP 2018138019-A/152693: Polycomb-Associated Non-Coding RNAs.
MA580766 - JP 2018138019-A/152692: Polycomb-Associated Non-Coding RNAs.
MA580764 - JP 2018138019-A/152690: Polycomb-Associated Non-Coding RNAs.
MA580763 - JP 2018138019-A/152689: Polycomb-Associated Non-Coding RNAs.
MA580761 - JP 2018138019-A/152687: Polycomb-Associated Non-Coding RNAs.
MA580759 - JP 2018138019-A/152685: Polycomb-Associated Non-Coding RNAs.
MA446855 - JP 2018138019-A/18781: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6H8W9, B2RTQ6, CEIP2_HUMAN, CEMIP2 , ENST00000377044.1, ENST00000377044.2, ENST00000377044.3, ENST00000377044.4, ENST00000377044.5, ENST00000377044.6, ENST00000377044.7, ENST00000377044.8, KIAA1412 , NM_013390, Q5T838, Q5T839, Q5T840, Q5T841, Q8NBP6, Q9P2D5, Q9UHN6, TMEM2 , uc318nit.1, uc318nit.2
UCSC ID: ENST00000377044.9_10
RefSeq Accession: NM_013390.3
Protein: Q9UHN6 (aka TMEM2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.