Human Gene TMEM234 (ENST00000309777.11_6) from GENCODE V47lift37
  Description: transmembrane protein 234, transcript variant 2 (from RefSeq NR_133634.2)
Gencode Transcript: ENST00000309777.11_6
Gencode Gene: ENSG00000160055.20_10
Transcript (Including UTRs)
   Position: hg19 chr1:32,681,801-32,687,954 Size: 6,154 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:32,682,454-32,687,923 Size: 5,470 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:32,681,801-32,687,954)mRNA (may differ from genome)Protein (140 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM234_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 234;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM234 family.
SEQUENCE CAUTION: Sequence=BAC11504.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.69 RPKM in Thyroid
Total median expression: 307.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.7031-0.055 Picture PostScript Text
3' UTR -237.00653-0.363 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018908 - UPF0546

Pfam Domains:
PF10639 - Putative transmembrane family 234

SCOP Domains:
103481 - Multidrug resistance efflux transporter EmrE

ModBase Predicted Comparative 3D Structure on Q8WY98
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ894303 - Synthetic construct Homo sapiens clone ccsbBroadEn_03697 TMEM234 gene, encodes complete protein.
KJ902901 - Synthetic construct Homo sapiens clone ccsbBroadEn_12295 TMEM234 gene, encodes complete protein.
LF206635 - JP 2014500723-A/14138: Polycomb-Associated Non-Coding RNAs.
AK075260 - Homo sapiens cDNA FLJ90779 fis, clone THYRO1001205.
BC001256 - Homo sapiens chromosome 1 open reading frame 91, mRNA (cDNA clone IMAGE:3463478).
BC038842 - Homo sapiens chromosome 1 open reading frame 91, mRNA (cDNA clone MGC:47790 IMAGE:5742036), complete cds.
AF258548 - Homo sapiens PP1065 mRNA, complete cds.
AK295232 - Homo sapiens cDNA FLJ57725 complete cds.
BC004885 - Homo sapiens chromosome 1 open reading frame 91, mRNA (cDNA clone MGC:11143 IMAGE:3837394), complete cds.
AY358586 - Homo sapiens clone DNA59612 AASL548 (UNQ548) mRNA, complete cds.
AL512700 - Homo sapiens mRNA; cDNA DKFZp667J115 (from clone DKFZp667J115).
JD072652 - Sequence 53676 from Patent EP1572962.
LF356773 - JP 2014500723-A/164276: Polycomb-Associated Non-Coding RNAs.
LF356772 - JP 2014500723-A/164275: Polycomb-Associated Non-Coding RNAs.
JD449184 - Sequence 430208 from Patent EP1572962.
AK312046 - Homo sapiens cDNA, FLJ92325.
HQ448040 - Synthetic construct Homo sapiens clone IMAGE:100071415; CCSB010271_01 chromosome 1 open reading frame 91 (C1orf91) gene, encodes complete protein.
CU691608 - Synthetic construct Homo sapiens gateway clone IMAGE:100020836 5' read C1orf91 mRNA.
JF432730 - Synthetic construct Homo sapiens clone IMAGE:100073973 chromosome 1 open reading frame 91 (C1orf91) gene, encodes complete protein.
KJ906251 - Synthetic construct Homo sapiens clone ccsbBroadEn_15921 TMEM234 gene, encodes complete protein.
MA442212 - JP 2018138019-A/14138: Polycomb-Associated Non-Coding RNAs.
MA592350 - JP 2018138019-A/164276: Polycomb-Associated Non-Coding RNAs.
MA592349 - JP 2018138019-A/164275: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R535, C1orf91, D3DPP7, ENST00000309777.1, ENST00000309777.10, ENST00000309777.2, ENST00000309777.3, ENST00000309777.4, ENST00000309777.5, ENST00000309777.6, ENST00000309777.7, ENST00000309777.8, ENST00000309777.9, NR_133634, PP1065, Q6UWY9, Q8N2H6, Q8WY98, Q9BSR2, Q9NU76, TM234_HUMAN, uc317opf.1, uc317opf.2, UNQ548/PRO1105
UCSC ID: ENST00000309777.11_6
RefSeq Accession: NM_019118.5
Protein: Q8WY98 (aka TM234_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.