Human Gene TMEM241 (ENST00000383233.8_8) from GENCODE V47lift37
  Description: transmembrane protein 241, transcript variant 9 (from RefSeq NR_148385.2)
Gencode Transcript: ENST00000383233.8_8
Gencode Gene: ENSG00000134490.14_11
Transcript (Including UTRs)
   Position: hg19 chr18:20,875,977-21,017,925 Size: 141,949 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr18:20,877,971-21,017,816 Size: 139,846 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:20,875,977-21,017,925)mRNA (may differ from genome)Protein (296 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM241_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 241;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM241 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM241
Diseases sorted by gene-association score: myeloproliferative syndrome, transient (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.21 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 52.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.70109-0.511 Picture PostScript Text
3' UTR -677.101994-0.340 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
103481 - Multidrug resistance efflux transporter EmrE

ModBase Predicted Comparative 3D Structure on Q24JQ0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005338 nucleotide-sugar transmembrane transporter activity

Biological Process:
GO:1990570 GDP-mannose transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK294916 - Homo sapiens cDNA FLJ60518 complete cds.
AK123623 - Homo sapiens cDNA FLJ41629 fis, clone DFNES2010502.
AK126247 - Homo sapiens cDNA FLJ44259 fis, clone TLIVE2000023.
BC114510 - Homo sapiens chromosome 18 open reading frame 45, mRNA (cDNA clone MGC:138577 IMAGE:40023922), complete cds.
BC114561 - Homo sapiens chromosome 18 open reading frame 45, mRNA (cDNA clone MGC:138578 IMAGE:40023923), complete cds.
KJ895076 - Synthetic construct Homo sapiens clone ccsbBroadEn_04470 TMEM241 gene, encodes complete protein.
AB253738 - Homo sapiens hVVT mRNA for putative vertebrate vrg4-like nucleotide-sugar transporter variant1, complete cds.
AB253739 - Homo sapiens hVVT mRNA for putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2, complete cds.
AK303553 - Homo sapiens cDNA FLJ57467 complete cds.
BC006280 - Homo sapiens chromosome 18 open reading frame 45, mRNA (cDNA clone IMAGE:3957352).
BC082984 - Homo sapiens chromosome 18 open reading frame 45, mRNA (cDNA clone IMAGE:6729630).
BC054507 - Homo sapiens chromosome 18 open reading frame 45, mRNA (cDNA clone IMAGE:3846642), partial cds.
JD554836 - Sequence 535860 from Patent EP1572962.
JD416064 - Sequence 397088 from Patent EP1572962.
JD049249 - Sequence 30273 from Patent EP1572962.
JD049254 - Sequence 30278 from Patent EP1572962.
JD301561 - Sequence 282585 from Patent EP1572962.
JD117000 - Sequence 98024 from Patent EP1572962.
JD360326 - Sequence 341350 from Patent EP1572962.
JD292783 - Sequence 273807 from Patent EP1572962.
JD177389 - Sequence 158413 from Patent EP1572962.
JD446976 - Sequence 428000 from Patent EP1572962.
JD511427 - Sequence 492451 from Patent EP1572962.
JD286556 - Sequence 267580 from Patent EP1572962.
JD533778 - Sequence 514802 from Patent EP1572962.
JD167658 - Sequence 148682 from Patent EP1572962.
JD481338 - Sequence 462362 from Patent EP1572962.
JD103823 - Sequence 84847 from Patent EP1572962.
JD038753 - Sequence 19777 from Patent EP1572962.
JD180842 - Sequence 161866 from Patent EP1572962.
JD520784 - Sequence 501808 from Patent EP1572962.
JD094406 - Sequence 75430 from Patent EP1572962.
JD459732 - Sequence 440756 from Patent EP1572962.
JD476521 - Sequence 457545 from Patent EP1572962.
JD560632 - Sequence 541656 from Patent EP1572962.
JD245942 - Sequence 226966 from Patent EP1572962.
JD448595 - Sequence 429619 from Patent EP1572962.
JD299482 - Sequence 280506 from Patent EP1572962.
JD333194 - Sequence 314218 from Patent EP1572962.
JD566678 - Sequence 547702 from Patent EP1572962.
JD361377 - Sequence 342401 from Patent EP1572962.
JD241971 - Sequence 222995 from Patent EP1572962.
JD523240 - Sequence 504264 from Patent EP1572962.
JD417989 - Sequence 399013 from Patent EP1572962.
JD465138 - Sequence 446162 from Patent EP1572962.
JD459574 - Sequence 440598 from Patent EP1572962.
JD459573 - Sequence 440597 from Patent EP1572962.
JD523239 - Sequence 504263 from Patent EP1572962.
JD417988 - Sequence 399012 from Patent EP1572962.
JD524146 - Sequence 505170 from Patent EP1572962.
JD378386 - Sequence 359410 from Patent EP1572962.
JD159823 - Sequence 140847 from Patent EP1572962.
JD505084 - Sequence 486108 from Patent EP1572962.
JD065588 - Sequence 46612 from Patent EP1572962.
JD426377 - Sequence 407401 from Patent EP1572962.
JD527139 - Sequence 508163 from Patent EP1572962.
JD167144 - Sequence 148168 from Patent EP1572962.
JD246278 - Sequence 227302 from Patent EP1572962.
JD375752 - Sequence 356776 from Patent EP1572962.
AK314123 - Homo sapiens cDNA, FLJ94820.
KJ903509 - Synthetic construct Homo sapiens clone ccsbBroadEn_12903 TMEM241 gene, encodes complete protein.
JD047144 - Sequence 28168 from Patent EP1572962.
JD181852 - Sequence 162876 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C18orf45, ENST00000383233.1, ENST00000383233.2, ENST00000383233.3, ENST00000383233.4, ENST00000383233.5, ENST00000383233.6, ENST00000383233.7, I0J130, NR_148385, Q24JQ0, Q6ZTS7, Q6ZW41, TM241_HUMAN, uc318rdj.1, uc318rdj.2
UCSC ID: ENST00000383233.8_8
RefSeq Accession: NM_032933.6
Protein: Q24JQ0 (aka TM241_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.