Human Gene LYSET (ENST00000283534.4_8) from GENCODE V47lift37
  Description: transmembrane protein 251, transcript variant 2 (from RefSeq NM_015676.3)
Gencode Transcript: ENST00000283534.4_8
Gencode Gene: ENSG00000153485.6_11
Transcript (Including UTRs)
   Position: hg19 chr14:93,651,296-93,653,431 Size: 2,136 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr14:93,652,621-93,653,016 Size: 396 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:93,651,296-93,653,431)mRNA (may differ from genome)Protein (131 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM251_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 251;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM251 family.
SEQUENCE CAUTION: Sequence=AAH30119.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.2098-0.410 Picture PostScript Text
3' UTR -93.60415-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15190 - Transmembrane protein 251

ModBase Predicted Comparative 3D Structure on Q8N6I4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AL080118 - Homo sapiens mRNA; cDNA DKFZp564F1123 (from clone DKFZp564F1123).
BC030119 - Homo sapiens chromosome 14 open reading frame 109, mRNA (cDNA clone IMAGE:4813313), partial cds.
JD364416 - Sequence 345440 from Patent EP1572962.
JD043369 - Sequence 24393 from Patent EP1572962.
JD330228 - Sequence 311252 from Patent EP1572962.
JD289611 - Sequence 270635 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C14orf109, ENST00000283534.1, ENST00000283534.2, ENST00000283534.3, J3KQ65, LYSET , LYSET_HUMAN, NM_015676, Q8N6I4, Q9Y4S5, TMEM251, uc317kcu.1, uc317kcu.2
UCSC ID: ENST00000283534.4_8
RefSeq Accession: NM_015676.3
Protein: Q8N6I4 (aka TM251_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.