Human Gene TMEM33 (ENST00000504986.6_4) from GENCODE V47lift37
  Description: transmembrane protein 33 (from RefSeq NM_018126.3)
Gencode Transcript: ENST00000504986.6_4
Gencode Gene: ENSG00000109133.14_9
Transcript (Including UTRs)
   Position: hg19 chr4:41,937,446-41,962,820 Size: 25,375 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr4:41,937,502-41,956,216 Size: 18,715 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:41,937,446-41,962,820)mRNA (may differ from genome)Protein (247 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM33_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 33; AltName: Full=Protein DB83;
INTERACTION: Q9HAW0:BRF2; NbExp=1; IntAct=EBI-1048629, EBI-1055224; Q99608:NDN; NbExp=1; IntAct=EBI-1048629, EBI-718177; P62140:PPP1CB; NbExp=1; IntAct=EBI-1048629, EBI-352350; O75365:PTP4A3; NbExp=1; IntAct=EBI-1048629, EBI-1043866;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: Belongs to the PER33/POM33 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM33
Diseases sorted by gene-association score: ichthyosis, congenital, autosomal recessive 11 (2), autosomal recessive congenital ichthyosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.55 RPKM in Pituitary
Total median expression: 244.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.9056-0.230 Picture PostScript Text
3' UTR -1631.606604-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005344 - UPF0121

Pfam Domains:
PF03661 - Transmembrane protein 33/Nucleoporin POM33

ModBase Predicted Comparative 3D Structure on P57088
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0017056 structural constituent of nuclear pore

Biological Process:
GO:0006913 nucleocytoplasmic transport
GO:0034613 cellular protein localization
GO:0034976 response to endoplasmic reticulum stress
GO:0051292 nuclear pore complex assembly
GO:1903371 regulation of endoplasmic reticulum tubular network organization
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1903899 positive regulation of PERK-mediated unfolded protein response

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042470 melanosome


-  Descriptions from all associated GenBank mRNAs
  LF383973 - JP 2014500723-A/191476: Polycomb-Associated Non-Coding RNAs.
AK023062 - Homo sapiens cDNA FLJ13000 fis, clone NT2RP3000333, highly similar to Rattus norvegicus db83 mRNA.
AK308501 - Homo sapiens cDNA, FLJ98542.
AK001387 - Homo sapiens cDNA FLJ10525 fis, clone NT2RP2000892.
AK094190 - Homo sapiens cDNA FLJ36871 fis, clone ASTRO2016892, highly similar to Transmembrane protein 33.
AY659966 - Homo sapiens SHINC3 (SHINC3) mRNA, complete cds.
BC000948 - Homo sapiens transmembrane protein 33, mRNA (cDNA clone MGC:4934 IMAGE:3448888), complete cds.
CU674470 - Synthetic construct Homo sapiens gateway clone IMAGE:100016881 5' read TMEM33 mRNA.
HQ447157 - Synthetic construct Homo sapiens clone IMAGE:100070445; CCSB000919_01 transmembrane protein 33 (TMEM33) gene, encodes complete protein.
KJ894145 - Synthetic construct Homo sapiens clone ccsbBroadEn_03539 TMEM33 gene, encodes complete protein.
CR457260 - Homo sapiens full open reading frame cDNA clone RZPDo834D129D for gene FLJ10525, hypothetical protein FLJ10525; complete cds, incl. stopcodon.
MA619550 - JP 2018138019-A/191476: Polycomb-Associated Non-Coding RNAs.
LF206856 - JP 2014500723-A/14359: Polycomb-Associated Non-Coding RNAs.
JD410024 - Sequence 391048 from Patent EP1572962.
JD227508 - Sequence 208532 from Patent EP1572962.
MA442433 - JP 2018138019-A/14359: Polycomb-Associated Non-Coding RNAs.
JD068510 - Sequence 49534 from Patent EP1572962.
JD219102 - Sequence 200126 from Patent EP1572962.
AK024587 - Homo sapiens cDNA: FLJ20934 fis, clone ADSE01518.
JD286262 - Sequence 267286 from Patent EP1572962.
JD345233 - Sequence 326257 from Patent EP1572962.
JD279831 - Sequence 260855 from Patent EP1572962.
JD360802 - Sequence 341826 from Patent EP1572962.
LF358663 - JP 2014500723-A/166166: Polycomb-Associated Non-Coding RNAs.
JD091940 - Sequence 72964 from Patent EP1572962.
JD292176 - Sequence 273200 from Patent EP1572962.
JD469592 - Sequence 450616 from Patent EP1572962.
LF358664 - JP 2014500723-A/166167: Polycomb-Associated Non-Coding RNAs.
AF403224 - Homo sapiens Shinc-3 mRNA, partial sequence.
JD503269 - Sequence 484293 from Patent EP1572962.
LF358665 - JP 2014500723-A/166168: Polycomb-Associated Non-Coding RNAs.
JD359806 - Sequence 340830 from Patent EP1572962.
JD153208 - Sequence 134232 from Patent EP1572962.
JD140621 - Sequence 121645 from Patent EP1572962.
JD153209 - Sequence 134233 from Patent EP1572962.
JD198429 - Sequence 179453 from Patent EP1572962.
JD161501 - Sequence 142525 from Patent EP1572962.
JD547569 - Sequence 528593 from Patent EP1572962.
JD547570 - Sequence 528594 from Patent EP1572962.
JD227532 - Sequence 208556 from Patent EP1572962.
JD374565 - Sequence 355589 from Patent EP1572962.
JD489239 - Sequence 470263 from Patent EP1572962.
JD489240 - Sequence 470264 from Patent EP1572962.
JD072025 - Sequence 53049 from Patent EP1572962.
JD072026 - Sequence 53050 from Patent EP1572962.
JD506186 - Sequence 487210 from Patent EP1572962.
JD256519 - Sequence 237543 from Patent EP1572962.
JD256520 - Sequence 237544 from Patent EP1572962.
JD120510 - Sequence 101534 from Patent EP1572962.
JD120511 - Sequence 101535 from Patent EP1572962.
JD379596 - Sequence 360620 from Patent EP1572962.
LF358666 - JP 2014500723-A/166169: Polycomb-Associated Non-Coding RNAs.
DL491192 - Novel nucleic acids.
LF358667 - JP 2014500723-A/166170: Polycomb-Associated Non-Coding RNAs.
LF358668 - JP 2014500723-A/166171: Polycomb-Associated Non-Coding RNAs.
JD473354 - Sequence 454378 from Patent EP1572962.
JD337609 - Sequence 318633 from Patent EP1572962.
JD213118 - Sequence 194142 from Patent EP1572962.
JD365029 - Sequence 346053 from Patent EP1572962.
LF358669 - JP 2014500723-A/166172: Polycomb-Associated Non-Coding RNAs.
LF358670 - JP 2014500723-A/166173: Polycomb-Associated Non-Coding RNAs.
JD043024 - Sequence 24048 from Patent EP1572962.
BC014384 - Homo sapiens, clone IMAGE:4052238, mRNA, partial cds.
AK056974 - Homo sapiens cDNA FLJ32412 fis, clone SKMUS2000690.
MA594240 - JP 2018138019-A/166166: Polycomb-Associated Non-Coding RNAs.
MA594241 - JP 2018138019-A/166167: Polycomb-Associated Non-Coding RNAs.
MA594242 - JP 2018138019-A/166168: Polycomb-Associated Non-Coding RNAs.
MA594243 - JP 2018138019-A/166169: Polycomb-Associated Non-Coding RNAs.
MA594244 - JP 2018138019-A/166170: Polycomb-Associated Non-Coding RNAs.
MA594245 - JP 2018138019-A/166171: Polycomb-Associated Non-Coding RNAs.
MA594246 - JP 2018138019-A/166172: Polycomb-Associated Non-Coding RNAs.
MA594247 - JP 2018138019-A/166173: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KSS8, DB83, ENST00000504986.1, ENST00000504986.2, ENST00000504986.3, ENST00000504986.4, ENST00000504986.5, NM_018126, P57088, Q9H953, TMM33_HUMAN, uc322zes.1, uc322zes.2
UCSC ID: ENST00000504986.6_4
RefSeq Accession: NM_018126.3
Protein: P57088 (aka TMM33_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.