Human Gene TMEM72 (ENST00000389583.5_5) from GENCODE V47lift37
  Description: transmembrane protein 72, transcript variant 1 (from RefSeq NM_001123376.3)
Gencode Transcript: ENST00000389583.5_5
Gencode Gene: ENSG00000187783.12_8
Transcript (Including UTRs)
   Position: hg19 chr10:45,406,785-45,432,458 Size: 25,674 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr10:45,406,961-45,430,582 Size: 23,622 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:45,406,785-45,432,458)mRNA (may differ from genome)Protein (275 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM72_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 72; AltName: Full=Kidney-specific secretory protein of 37 kDa;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.02 RPKM in Kidney - Cortex
Total median expression: 32.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.30176-0.382 Picture PostScript Text
3' UTR -713.101876-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF16054 - Transmembrane protein family 72

ModBase Predicted Comparative 3D Structure on A0PK05
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ896320 - Synthetic construct Homo sapiens clone ccsbBroadEn_05714 TMEM72 gene, encodes complete protein.
BX538120 - Homo sapiens mRNA; cDNA DKFZp686M0585 (from clone DKFZp686M0585).
BC127789 - Homo sapiens transmembrane protein 72, mRNA (cDNA clone MGC:157906 IMAGE:40133552), complete cds.
BC127790 - Homo sapiens transmembrane protein 72, mRNA (cDNA clone MGC:157907 IMAGE:40133554), complete cds.
AB235418 - Homo sapiens KSP37 mRNA for kidney-specific secretory protein of 37 kDa, complete cds.
BC029135 - Homo sapiens, clone IMAGE:5189562, mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A0PK05, A1L181, C10orf127, ENST00000389583.1, ENST00000389583.2, ENST00000389583.3, ENST00000389583.4, KSP37, NM_001123376, Q5T740, TMM72_HUMAN, uc318tga.1, uc318tga.2
UCSC ID: ENST00000389583.5_5
RefSeq Accession: NM_001123376.3
Protein: A0PK05 (aka TMM72_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.