Human Gene TMX1 (ENST00000457354.7_4) from GENCODE V47lift37
  Description: thioredoxin related transmembrane protein 1 (from RefSeq NM_030755.5)
Gencode Transcript: ENST00000457354.7_4
Gencode Gene: ENSG00000139921.13_7
Transcript (Including UTRs)
   Position: hg19 chr14:51,706,965-51,724,373 Size: 17,409 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr14:51,707,011-51,721,237 Size: 14,227 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:51,706,965-51,724,373)mRNA (may differ from genome)Protein (280 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMX1_HUMAN
DESCRIPTION: RecName: Full=Thioredoxin-related transmembrane protein 1; AltName: Full=Thioredoxin domain-containing protein 1; AltName: Full=Transmembrane Trx-related protein; Flags: Precursor;
FUNCTION: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Note=Predominantly found in the endoplasmic reticulum.
TISSUE SPECIFICITY: Ubiquitous. Highly expressed in kidney, liver, placenta and lung.
SIMILARITY: Contains 1 thioredoxin domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 480.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.8046-0.365 Picture PostScript Text
3' UTR -699.403136-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012336 - Thioredoxin-like_fold
IPR017937 - Thioredoxin_CS
IPR013766 - Thioredoxin_domain

Pfam Domains:
PF00085 - Thioredoxin

SCOP Domains:
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1X5E - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9H3N1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003756 protein disulfide isomerase activity
GO:0015036 disulfide oxidoreductase activity

Biological Process:
GO:0006457 protein folding
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB048246 - Homo sapiens TMX mRNA for thioredoxin-related transmembrane protein, complete cds.
AK302416 - Homo sapiens cDNA FLJ51569 complete cds, highly similar to Thioredoxin domain-containing protein 1 precursor.
BC036460 - Homo sapiens thioredoxin-related transmembrane protein 1, mRNA (cDNA clone MGC:33494 IMAGE:4814497), complete cds.
LF209554 - JP 2014500723-A/17057: Polycomb-Associated Non-Coding RNAs.
BC016769 - Homo sapiens thioredoxin-related transmembrane protein 1, mRNA (cDNA clone IMAGE:4102410), with apparent retained intron.
BC050366 - Homo sapiens cDNA clone IMAGE:5764221, containing frame-shift errors.
AK075395 - Homo sapiens cDNA PSEC0085 fis, clone NT2RP2006476, highly similar to Thioredoxin domain containing protein.
BC032834 - Homo sapiens cDNA clone IMAGE:4838860, containing frame-shift errors.
AK303134 - Homo sapiens cDNA FLJ51570 complete cds, highly similar to Thioredoxin domain-containing protein 1 precursor.
AL080080 - Homo sapiens mRNA; cDNA DKFZp564E1962 (from clone DKFZp564E1962).
BC056874 - Homo sapiens thioredoxin-related transmembrane protein 1, mRNA (cDNA clone MGC:64936 IMAGE:5740203), complete cds.
AY358640 - Homo sapiens clone DNA39427 TXNDC (UNQ235) mRNA, complete cds.
AK312905 - Homo sapiens cDNA, FLJ93352, Homo sapiens thioredoxin domain-containing (TXNDC), mRNA.
DQ894860 - Synthetic construct Homo sapiens clone IMAGE:100009320; FLH179173.01L; RZPDo839D08129D thioredoxin domain containing (TXNDC) gene, encodes complete protein.
KJ899673 - Synthetic construct Homo sapiens clone ccsbBroadEn_09067 TMX1 gene, encodes complete protein.
DQ891674 - Synthetic construct clone IMAGE:100004304; FLH179177.01X; RZPDo839D08130D thioredoxin domain containing (TXNDC) gene, encodes complete protein.
CU690352 - Synthetic construct Homo sapiens gateway clone IMAGE:100018710 5' read TXNDC1 mRNA.
KJ899672 - Synthetic construct Homo sapiens clone ccsbBroadEn_09066 TMX1 gene, encodes complete protein.
LF329464 - JP 2014500723-A/136967: Polycomb-Associated Non-Coding RNAs.
LF329465 - JP 2014500723-A/136968: Polycomb-Associated Non-Coding RNAs.
LF329466 - JP 2014500723-A/136969: Polycomb-Associated Non-Coding RNAs.
LF329468 - JP 2014500723-A/136971: Polycomb-Associated Non-Coding RNAs.
JD566796 - Sequence 547820 from Patent EP1572962.
LF329469 - JP 2014500723-A/136972: Polycomb-Associated Non-Coding RNAs.
LF329470 - JP 2014500723-A/136973: Polycomb-Associated Non-Coding RNAs.
JD088958 - Sequence 69982 from Patent EP1572962.
LF329471 - JP 2014500723-A/136974: Polycomb-Associated Non-Coding RNAs.
LF329472 - JP 2014500723-A/136975: Polycomb-Associated Non-Coding RNAs.
LF329473 - JP 2014500723-A/136976: Polycomb-Associated Non-Coding RNAs.
LF329474 - JP 2014500723-A/136977: Polycomb-Associated Non-Coding RNAs.
LF329475 - JP 2014500723-A/136978: Polycomb-Associated Non-Coding RNAs.
JD093691 - Sequence 74715 from Patent EP1572962.
JD281225 - Sequence 262249 from Patent EP1572962.
JD527415 - Sequence 508439 from Patent EP1572962.
LF329476 - JP 2014500723-A/136979: Polycomb-Associated Non-Coding RNAs.
MA565041 - JP 2018138019-A/136967: Polycomb-Associated Non-Coding RNAs.
MA565042 - JP 2018138019-A/136968: Polycomb-Associated Non-Coding RNAs.
MA565043 - JP 2018138019-A/136969: Polycomb-Associated Non-Coding RNAs.
MA565045 - JP 2018138019-A/136971: Polycomb-Associated Non-Coding RNAs.
MA565046 - JP 2018138019-A/136972: Polycomb-Associated Non-Coding RNAs.
MA565047 - JP 2018138019-A/136973: Polycomb-Associated Non-Coding RNAs.
MA565048 - JP 2018138019-A/136974: Polycomb-Associated Non-Coding RNAs.
MA565049 - JP 2018138019-A/136975: Polycomb-Associated Non-Coding RNAs.
MA565050 - JP 2018138019-A/136976: Polycomb-Associated Non-Coding RNAs.
MA565051 - JP 2018138019-A/136977: Polycomb-Associated Non-Coding RNAs.
MA565052 - JP 2018138019-A/136978: Polycomb-Associated Non-Coding RNAs.
MA565053 - JP 2018138019-A/136979: Polycomb-Associated Non-Coding RNAs.
MA445131 - JP 2018138019-A/17057: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7A4, ENST00000457354.1, ENST00000457354.2, ENST00000457354.3, ENST00000457354.4, ENST00000457354.5, ENST00000457354.6, NM_030755, PSEC0085, Q8N487, Q8NBN5, Q9H3N1, Q9Y4T6, TMX , TMX1 , TMX1_HUMAN, TXNDC, TXNDC1, uc320ygr.1, uc320ygr.2, UNQ235/PRO268
UCSC ID: ENST00000457354.7_4
RefSeq Accession: NM_030755.5
Protein: Q9H3N1 (aka TMX1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.