Human Gene TNFAIP2 (ENST00000560869.6_8) from GENCODE V47lift37
  Description: TNF alpha induced protein 2, transcript variant 1 (from RefSeq NM_006291.4)
Gencode Transcript: ENST00000560869.6_8
Gencode Gene: ENSG00000185215.11_17
Transcript (Including UTRs)
   Position: hg19 chr14:103,589,798-103,603,776 Size: 13,979 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr14:103,592,795-103,601,697 Size: 8,903 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:103,589,798-103,603,776)mRNA (may differ from genome)Protein (654 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TNAP2_HUMAN
DESCRIPTION: RecName: Full=Tumor necrosis factor alpha-induced protein 2; Short=TNF alpha-induced protein 2; AltName: Full=Primary response gene B94 protein;
FUNCTION: May play a role as a mediator of inflammation and angiogenesis.
DEVELOPMENTAL STAGE: Differentially expressed in development and capillary tube-like formation in vitro.
INDUCTION: By TNF and other proinflammatory factors.
SIMILARITY: Belongs to the SEC6 family.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tnfaip2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 97.04 RPKM in Spleen
Total median expression: 1226.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -310.50639-0.486 Picture PostScript Text
3' UTR -843.702079-0.406 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010326 - Sec6

Pfam Domains:
PF06046 - Exocyst complex component Sec6

ModBase Predicted Comparative 3D Structure on Q03169
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding

Biological Process:
GO:0001525 angiogenesis
GO:0006887 exocytosis
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
GO:0051601 exocyst localization

Cellular Component:
GO:0000145 exocyst
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC017818 - Homo sapiens cDNA clone IMAGE:4655505.
M92357 - Homo sapiens B94 protein mRNA, complete cds.
BC128449 - Homo sapiens tumor necrosis factor, alpha-induced protein 2, mRNA (cDNA clone MGC:156264 IMAGE:40122621), complete cds.
BC128450 - Homo sapiens tumor necrosis factor, alpha-induced protein 2, mRNA (cDNA clone IMAGE:40122622).
JD052270 - Sequence 33294 from Patent EP1572962.
JD112716 - Sequence 93740 from Patent EP1572962.
LF326319 - JP 2014500723-A/133822: Polycomb-Associated Non-Coding RNAs.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JD211267 - Sequence 192291 from Patent EP1572962.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
KJ901802 - Synthetic construct Homo sapiens clone ccsbBroadEn_11196 TNFAIP2 gene, encodes complete protein.
AK302929 - Homo sapiens cDNA FLJ50311 complete cds, highly similar to Tumor necrosis factor, alpha-induced protein 2.
AK303781 - Homo sapiens cDNA FLJ56842 complete cds, highly similar to Tumor necrosis factor, alpha-induced protein 2.
AK316496 - Homo sapiens cDNA, FLJ79395 complete cds, highly similar to Tumor necrosis factor, alpha-induced protein 2.
DQ574083 - Homo sapiens piRNA piR-42195, complete sequence.
AK309854 - Homo sapiens cDNA, FLJ99895.
JD433195 - Sequence 414219 from Patent EP1572962.
JD525990 - Sequence 507014 from Patent EP1572962.
JD256203 - Sequence 237227 from Patent EP1572962.
JD100313 - Sequence 81337 from Patent EP1572962.
JD061781 - Sequence 42805 from Patent EP1572962.
JD445461 - Sequence 426485 from Patent EP1572962.
JD527623 - Sequence 508647 from Patent EP1572962.
JD546999 - Sequence 528023 from Patent EP1572962.
JD103969 - Sequence 84993 from Patent EP1572962.
JD122637 - Sequence 103661 from Patent EP1572962.
JD389132 - Sequence 370156 from Patent EP1572962.
JD408272 - Sequence 389296 from Patent EP1572962.
JD183492 - Sequence 164516 from Patent EP1572962.
JD316595 - Sequence 297619 from Patent EP1572962.
JD222783 - Sequence 203807 from Patent EP1572962.
JD057691 - Sequence 38715 from Patent EP1572962.
JD210418 - Sequence 191442 from Patent EP1572962.
JD191382 - Sequence 172406 from Patent EP1572962.
JD126375 - Sequence 107399 from Patent EP1572962.
JD130266 - Sequence 111290 from Patent EP1572962.
JD480126 - Sequence 461150 from Patent EP1572962.
JD043237 - Sequence 24261 from Patent EP1572962.
JD107782 - Sequence 88806 from Patent EP1572962.
JD266374 - Sequence 247398 from Patent EP1572962.
JD475218 - Sequence 456242 from Patent EP1572962.
JD453427 - Sequence 434451 from Patent EP1572962.
JD108955 - Sequence 89979 from Patent EP1572962.
JD459279 - Sequence 440303 from Patent EP1572962.
JD232609 - Sequence 213633 from Patent EP1572962.
JD547751 - Sequence 528775 from Patent EP1572962.
JD475380 - Sequence 456404 from Patent EP1572962.
JD417916 - Sequence 398940 from Patent EP1572962.
JD253897 - Sequence 234921 from Patent EP1572962.
JD334722 - Sequence 315746 from Patent EP1572962.
JD390710 - Sequence 371734 from Patent EP1572962.
JD541290 - Sequence 522314 from Patent EP1572962.
JD545758 - Sequence 526782 from Patent EP1572962.
JD250087 - Sequence 231111 from Patent EP1572962.
JD355484 - Sequence 336508 from Patent EP1572962.
JD110882 - Sequence 91906 from Patent EP1572962.
JD350817 - Sequence 331841 from Patent EP1572962.
JD511950 - Sequence 492974 from Patent EP1572962.
JD362065 - Sequence 343089 from Patent EP1572962.
JD213358 - Sequence 194382 from Patent EP1572962.
JD367670 - Sequence 348694 from Patent EP1572962.
JD151233 - Sequence 132257 from Patent EP1572962.
JD489191 - Sequence 470215 from Patent EP1572962.
JD287042 - Sequence 268066 from Patent EP1572962.
JD253630 - Sequence 234654 from Patent EP1572962.
JD566296 - Sequence 547320 from Patent EP1572962.
JD130815 - Sequence 111839 from Patent EP1572962.
JD342663 - Sequence 323687 from Patent EP1572962.
JD255801 - Sequence 236825 from Patent EP1572962.
JD346709 - Sequence 327733 from Patent EP1572962.
JD061829 - Sequence 42853 from Patent EP1572962.
JD179848 - Sequence 160872 from Patent EP1572962.
JD482975 - Sequence 463999 from Patent EP1572962.
JD180490 - Sequence 161514 from Patent EP1572962.
JD038721 - Sequence 19745 from Patent EP1572962.
MA561896 - JP 2018138019-A/133822: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000560869.1, ENST00000560869.2, ENST00000560869.3, ENST00000560869.4, ENST00000560869.5, NM_006291, Q03169, Q86VI0, TNAP2_HUMAN, uc325otj.1, uc325otj.2
UCSC ID: ENST00000560869.6_8
RefSeq Accession: NM_006291.4
Protein: Q03169 (aka TNAP2_HUMAN or TNI2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.