Human Gene TNFRSF10C (ENST00000356864.4_5) from GENCODE V47lift37
  Description: TNF receptor superfamily member 10c (from RefSeq NM_003841.5)
Gencode Transcript: ENST00000356864.4_5
Gencode Gene: ENSG00000173535.15_7
Transcript (Including UTRs)
   Position: hg19 chr8:22,960,434-22,974,958 Size: 14,525 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr8:22,960,635-22,974,544 Size: 13,910 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:22,960,434-22,974,958)mRNA (may differ from genome)Protein (259 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TR10C_HUMAN
DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 10C; AltName: Full=Antagonist decoy receptor for TRAIL/Apo-2L; AltName: Full=Decoy TRAIL receptor without death domain; AltName: Full=Decoy receptor 1; Short=DcR1; AltName: Full=Lymphocyte inhibitor of TRAIL; AltName: Full=TNF-related apoptosis-inducing ligand receptor 3; Short=TRAIL receptor 3; Short=TRAIL-R3; AltName: Full=TRAIL receptor without an intracellular domain; AltName: CD_antigen=CD263; Flags: Precursor;
FUNCTION: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
TISSUE SPECIFICITY: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
PTM: N-glycosylated and O-glycosylated.
SIMILARITY: Contains 3 TNFR-Cys repeats.
SEQUENCE CAUTION: Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 109.67 RPKM in Whole Blood
Total median expression: 143.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -76.30201-0.380 Picture PostScript Text
3' UTR -161.20414-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001368 - TNFR/NGFR_Cys_rich_reg
IPR020465 - TNFR_10

Pfam Domains:
PF00020 - TNFR/NGFR cysteine-rich region

SCOP Domains:
57586 - TNF receptor-like
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on O14798
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0045569 TRAIL binding

Biological Process:
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 apoptotic signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC021569 - Homo sapiens hypothetical protein MGC31957, mRNA (cDNA clone MGC:31957 IMAGE:3959651), complete cds.
BC005043 - Homo sapiens hypothetical protein MGC31957, mRNA (cDNA clone MGC:12787 IMAGE:4039959), complete cds.
BC017852 - Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, mRNA (cDNA clone IMAGE:4700855), partial cds.
AK298664 - Homo sapiens cDNA FLJ52013 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 10C precursor.
AK313213 - Homo sapiens cDNA, FLJ93714, highly similar to Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C), mRNA.
AK298718 - Homo sapiens cDNA FLJ53081 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 10C precursor.
AY358281 - Homo sapiens clone DNA33085 DcR1-TNFR (UNQ321) mRNA, complete cds.
AF012536 - Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds.
AF016267 - Homo sapiens TRAIL receptor 3 mRNA, complete cds.
AF033854 - Homo sapiens lymphocyte inhibitor of TRAIL (LIT) mRNA, complete cds.
AF014794 - Homo sapiens TNF related TRAIL receptor (TNFRSF10C) mRNA, complete cds.
BC125041 - Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, mRNA (cDNA clone MGC:149501 IMAGE:40115748), complete cds.
BC125042 - Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, mRNA (cDNA clone MGC:149502 IMAGE:40115749), complete cds.
JF432560 - Synthetic construct Homo sapiens clone IMAGE:100073790 hypothetical protein MGC31957 (MGC31957) gene, encodes complete protein.
KJ904068 - Synthetic construct Homo sapiens clone ccsbBroadEn_13462 LOC254896 gene, encodes complete protein.
AF020502 - Homo sapiens cytotoxic TRAIL receptor-3 (TRAIL-R3) mRNA, complete cds.
JD127924 - Sequence 108948 from Patent EP1572962.
KJ892621 - Synthetic construct Homo sapiens clone ccsbBroadEn_02015 TNFRSF10C gene, encodes complete protein.
AF012629 - Homo sapiens antagonist decoy receptor for TRAIL/Apo-2L (TRID) mRNA, complete cds.
CR541857 - Homo sapiens full open reading frame cDNA clone RZPDo834G0632D for gene TNFRSF10C, tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; complete cds, incl. stopcodon.
JD462083 - Sequence 443107 from Patent EP1572962.
JD157671 - Sequence 138695 from Patent EP1572962.
JD259529 - Sequence 240553 from Patent EP1572962.
JD398068 - Sequence 379092 from Patent EP1572962.
JD519535 - Sequence 500559 from Patent EP1572962.
JD549207 - Sequence 530231 from Patent EP1572962.
JD190535 - Sequence 171559 from Patent EP1572962.
JD123108 - Sequence 104132 from Patent EP1572962.
JD228373 - Sequence 209397 from Patent EP1572962.
JD159809 - Sequence 140833 from Patent EP1572962.
JD249005 - Sequence 230029 from Patent EP1572962.
JD521203 - Sequence 502227 from Patent EP1572962.
JD095741 - Sequence 76765 from Patent EP1572962.
JD408287 - Sequence 389311 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O14798 (Reactome details) participates in the following event(s):

R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: DCR1, ENST00000356864.1, ENST00000356864.2, ENST00000356864.3, LIT, NM_003841, O14755, O14798, Q08AS6, Q6FH98, Q6UXM5, TR10C_HUMAN, TRAILR3, TRID, uc317ztp.1, uc317ztp.2, UNQ321/PRO366
UCSC ID: ENST00000356864.4_5
RefSeq Accession: NM_003841.5
Protein: O14798 (aka TR10C_HUMAN or T10C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.