ID:TN13B_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor ligand superfamily member 13B; AltName: Full=B lymphocyte stimulator; Short=BLyS; AltName: Full=B-cell-activating factor; AltName: Full=BAFF; AltName: Full=Dendritic cell-derived TNF-like molecule; AltName: Full=TNF- and APOL-related leukocyte expressed ligand 1; Short=TALL-1; AltName: CD_antigen=CD257; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 13b, membrane form; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 13b, soluble form; FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity). SUBUNIT: Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. INTERACTION: O14836:TNFRSF13B; NbExp=7; IntAct=EBI-519169, EBI-519160; SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted. TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. INDUCTION: Up-regulated by exposure to IFNG/IFN-gamma. Down- regulated by phorbol myristate acetate/ionomycin treatment. PTM: The soluble form derives from the membrane form by proteolytic processing. PTM: Isoform 2 is not efficiently shed from the membrane unlike isoform 1 (By similarity). PTM: N-glycosylated. SIMILARITY: Belongs to the tumor necrosis factor family. WEB RESOURCE: Name=Protein Spotlight; Note=Proteic grace - Issue 77 of December 2006; URL="http://web.expasy.org/spotlight/back_issues/sptlt077.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y275
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001782 B cell homeostasis GO:0002376 immune system process GO:0002636 positive regulation of germinal center formation GO:0006955 immune response GO:0007165 signal transduction GO:0008283 cell proliferation GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0030890 positive regulation of B cell proliferation GO:0031295 T cell costimulation GO:0031296 B cell costimulation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042102 positive regulation of T cell proliferation GO:0048305 immunoglobulin secretion GO:0050776 regulation of immune response
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
