Human Gene TNP1 (ENST00000236979.2_7) from GENCODE V47lift37

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Description: transition protein 1 (from RefSeq NM_003284.4)
Gencode Transcript: ENST00000236979.2_7
Gencode Gene: ENSG00000118245.2_8
Transcript (Including UTRs)
Position: hg19 chr2:217,724,181-217,724,787 Size: 607 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr2:217,724,390-217,724,757 Size: 368 Coding Exon Count: 2

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:217,724,181-217,724,787)			mRNA (may differ from genome)		Protein (55 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TNP1 Diseases sorted by gene-association score: epididymo-orchitis (11), aggressive systemic mastocytosis (5), male infertility (5), male reproductive system disease (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C028451 3,4,3',4'-tetrachlorobiphenyl D000643 Ammonium Chloride D008727 Methotrexate D010795 Phthalic Acids D059808 Polyphenols D014501 Uranium C006780 bisphenol A C039281 furan C017461 lead nitrate C005460 uranyl acetate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4297.26 RPKM in Testis Total median expression: 4304.99 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-2.60	30	-0.087	Picture	PostScript	Text
3' UTR	-48.30	209	-0.231	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001319 - Nuclear_transition_prot1
IPR020062 - Nuclear_transition_prot1_CS

Pfam Domains:
PF02079 - Nuclear transition protein 1

ModBase Predicted Comparative 3D Structure on Q4ZG82


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding Biological Process: GO:0007283 spermatogenesis GO:0010954 positive regulation of protein processing GO:0035093 spermatogenesis, exchange of chromosomal proteins Cellular Component: GO:0000786 nucleosome GO:0000788 nuclear nucleosome GO:0001673 male germ cell nucleus GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	BC029516 - Homo sapiens transition protein 1 (during histone to protamine replacement), mRNA (cDNA clone MGC:33798 IMAGE:5272281), complete cds. X07948 - Human mRNA for transition protein 1 (TP1). JD382438 - Sequence 363462 from Patent EP1572962. HQ448184 - Synthetic construct Homo sapiens clone IMAGE:100071578; CCSB002110_02 transition protein 1 (during histone to protamine replacement) (TNP1) gene, encodes complete protein. KJ892301 - Synthetic construct Homo sapiens clone ccsbBroadEn_01695 TNP1 gene, encodes complete protein.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000236979.1, hCG_16381 , NM_003284, Q4ZG82, Q4ZG82_HUMAN, TNP1 , uc317ebt.1, uc317ebt.2 UCSC ID: ENST00000236979.2_7 RefSeq Accession: NM_003284.4 Protein: Q4ZG82

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.