ID:TNPO1_HUMAN DESCRIPTION: RecName: Full=Transportin-1; AltName: Full=Importin beta-2; AltName: Full=Karyopherin beta-2; AltName: Full=M9 region interaction protein; Short=MIP; FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. SUBUNIT: Binds HNRPA1, HNRPA2, HNRPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-286693, EBI-401755; P62826:RAN; NbExp=2; IntAct=EBI-286693, EBI-286642; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. SIMILARITY: Belongs to the importin beta family. SIMILARITY: Contains 8 HEAT repeats. SIMILARITY: Contains 1 importin N-terminal domain. SEQUENCE CAUTION: Sequence=AAC50723.1; Type=Erroneous initiation; Sequence=AAH40340.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92973
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0006607 NLS-bearing protein import into nucleus GO:0006610 ribosomal protein import into nucleus GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0016032 viral process GO:0035735 intraciliary transport involved in cilium assembly GO:0043488 regulation of mRNA stability
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
