ID:TENS3_HUMAN DESCRIPTION: RecName: Full=Tensin-3; AltName: Full=Tensin-like SH2 domain-containing protein 1; AltName: Full=Tumor endothelial marker 6; FUNCTION: May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity). SUBUNIT: EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions. INTERACTION: P56945:BCAR1; NbExp=8; IntAct=EBI-1220488, EBI-702093; P12830:CDH1; NbExp=2; IntAct=EBI-1220488, EBI-727477; Q05397:PTK2; NbExp=3; IntAct=EBI-1220488, EBI-702142; P12931:SRC; NbExp=13; IntAct=EBI-1220488, EBI-621482; SUBCELLULAR LOCATION: Cell junction, focal adhesion. TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. INDUCTION: Down-regulated by EGF. PTM: EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner. SIMILARITY: Contains 1 C2 tensin-type domain. SIMILARITY: Contains 1 phosphatase tensin-type domain. SIMILARITY: Contains 1 SH2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q68CZ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
