ID:TENX_HUMAN DESCRIPTION: RecName: Full=Tenascin-X; Short=TN-X; AltName: Full=Hexabrachion-like protein; Flags: Precursor; FUNCTION: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. SUBUNIT: Homotrimer. Interacts with type I, III and V collagens and tropoelastin via its 29th fibronectin type-III domain. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB- short is only expressed in the adrenal gland. DEVELOPMENTAL STAGE: Expression levels are lower in adults than in children. DISEASE: Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:606408]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers- Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. SIMILARITY: Belongs to the tenascin family. SIMILARITY: Contains 19 EGF-like domains. SIMILARITY: Contains 1 fibrinogen C-terminal domain. SIMILARITY: Contains 32 fibronectin type-III domains. CAUTION: There are two genes for TN-X: TNXA and TNXB. TNXA is a partial gene which can sometimes recombine with TNXB. SEQUENCE CAUTION: Sequence=AAH33740.1; Type=Erroneous initiation; Sequence=CAB89296.1; Type=Erroneous initiation; Sequence=CAI17414.1; Type=Erroneous gene model prediction; Sequence=CAI17471.1; Type=Erroneous gene model prediction; Sequence=CAI18078.1; Type=Erroneous gene model prediction; Sequence=CAI18332.1; Type=Erroneous gene model prediction; Sequence=CAQ09268.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TNXB";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22105
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
