Human Gene TOB2 (ENST00000327492.4_7) from GENCODE V47lift37
  Description: transducer of ERBB2, 2 (from RefSeq NM_016272.4)
Gencode Transcript: ENST00000327492.4_7
Gencode Gene: ENSG00000183864.6_11
Transcript (Including UTRs)
   Position: hg19 chr22:41,829,498-41,842,805 Size: 13,308 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr22:41,832,315-41,833,349 Size: 1,035 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:41,829,498-41,842,805)mRNA (may differ from genome)Protein (344 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TOB2_HUMAN
DESCRIPTION: RecName: Full=Protein Tob2; AltName: Full=Protein Tob4; AltName: Full=Transducer of erbB-2 2;
FUNCTION: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
SUBUNIT: Associates with CAF1.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the BTG family.
SEQUENCE CAUTION: Sequence=BAB33333.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TOB2
Diseases sorted by gene-association score: primary hypomagnesemia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.37 RPKM in Artery - Tibial
Total median expression: 1124.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -200.50485-0.413 Picture PostScript Text
3' UTR -978.702817-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002087 - Anti_prolifrtn
IPR009818 - Ataxin-2_C
IPR015676 - Tob
IPR015678 - Tob2

Pfam Domains:
PF07145 - Ataxin-2 C-terminal region
PF07742 - BTG family

SCOP Domains:
160696 - BTG domain-like

ModBase Predicted Comparative 3D Structure on Q14106
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042809 vitamin D receptor binding

Biological Process:
GO:0007292 female gamete generation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0023052 signaling
GO:0045671 negative regulation of osteoclast differentiation
GO:0045778 positive regulation of ossification
GO:1903507 negative regulation of nucleic acid-templated transcription

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF210379 - JP 2014500723-A/17882: Polycomb-Associated Non-Coding RNAs.
AL133080 - Homo sapiens mRNA; cDNA DKFZp434A0727 (from clone DKFZp434A0727).
BC038957 - Homo sapiens transducer of ERBB2, 2, mRNA (cDNA clone MGC:47645 IMAGE:5786640), complete cds.
AB051450 - Homo sapiens KIAA1663 mRNA for KIAA1663 protein.
JD183679 - Sequence 164703 from Patent EP1572962.
JD412568 - Sequence 393592 from Patent EP1572962.
JD525508 - Sequence 506532 from Patent EP1572962.
JD502012 - Sequence 483036 from Patent EP1572962.
JD111308 - Sequence 92332 from Patent EP1572962.
JD510361 - Sequence 491385 from Patent EP1572962.
JD067887 - Sequence 48911 from Patent EP1572962.
JD324866 - Sequence 305890 from Patent EP1572962.
JD074408 - Sequence 55432 from Patent EP1572962.
JD500393 - Sequence 481417 from Patent EP1572962.
DQ595469 - Homo sapiens piRNA piR-61581, complete sequence.
JD378745 - Sequence 359769 from Patent EP1572962.
LF337415 - JP 2014500723-A/144918: Polycomb-Associated Non-Coding RNAs.
LF337416 - JP 2014500723-A/144919: Polycomb-Associated Non-Coding RNAs.
AB035207 - Homo sapiens mRNA for Tob2, complete cds.
D64109 - Homo sapiens mRNA for tob family, complete cds.
CR456594 - Homo sapiens TOB2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.TOB2).
CU013194 - Homo sapiens TOB2, mRNA (cDNA clone IMAGE:100000547), complete cds, with stop codon, in Gateway system.
AB384255 - Synthetic construct DNA, clone: pF1KSDA1663, Homo sapiens TOB2 gene for transducer of ERBB2, 2, complete cds, without stop codon, in Flexi system.
CR541684 - Homo sapiens full open reading frame cDNA clone RZPDo834A0728D for gene TOB2, transducer of ERBB2, 2; complete cds, without stopcodon.
CU013482 - Homo sapiens TOB2, mRNA (cDNA clone IMAGE:100000451), complete cds, without stop codon, in Gateway system.
BC028919 - Homo sapiens transducer of ERBB2, 2, mRNA (cDNA clone MGC:24875 IMAGE:4940977), complete cds.
DQ576024 - Homo sapiens piRNA piR-44136, complete sequence.
DQ591725 - Homo sapiens piRNA piR-58837, complete sequence.
DQ586588 - Homo sapiens piRNA piR-53700, complete sequence.
LF337417 - JP 2014500723-A/144920: Polycomb-Associated Non-Coding RNAs.
JD470429 - Sequence 451453 from Patent EP1572962.
JD101053 - Sequence 82077 from Patent EP1572962.
JD159297 - Sequence 140321 from Patent EP1572962.
JD484600 - Sequence 465624 from Patent EP1572962.
JD144370 - Sequence 125394 from Patent EP1572962.
MA445956 - JP 2018138019-A/17882: Polycomb-Associated Non-Coding RNAs.
MA572992 - JP 2018138019-A/144918: Polycomb-Associated Non-Coding RNAs.
MA572993 - JP 2018138019-A/144919: Polycomb-Associated Non-Coding RNAs.
MA572994 - JP 2018138019-A/144920: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_tob1Pathway - Role of Tob in T-cell activation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000327492.1, ENST00000327492.2, ENST00000327492.3, KIAA1663, NM_016272, Q14106, Q6FHR7, Q6PIT9, Q9BY97, Q9UBI0, TOB2_HUMAN, TOB4, TROB2, uc317shj.1, uc317shj.2
UCSC ID: ENST00000327492.4_7
RefSeq Accession: NM_016272.4
Protein: Q14106 (aka TOB2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.