ID:TOM22_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM22 homolog; Short=hTom22; AltName: Full=1C9-2; AltName: Full=Translocase of outer membrane 22 kDa subunit homolog; FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40. Interacts with PPP2R2B (By similarity). INTERACTION: Q9P0U1:TOMM7; NbExp=2; IntAct=EBI-1047508, EBI-1180558; SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein (By similarity). TISSUE SPECIFICITY: Ubiquitous. DOMAIN: Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. SIMILARITY: Belongs to the Tom22 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS69
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008320 protein transmembrane transporter activity
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0030150 protein import into mitochondrial matrix GO:0043065 positive regulation of apoptotic process GO:0045040 protein import into mitochondrial outer membrane GO:0051204 protein insertion into mitochondrial membrane
Cellular Component: GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0005742 mitochondrial outer membrane translocase complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0031307 integral component of mitochondrial outer membrane
Descriptions from all associated GenBank mRNAs
AK223021 - Homo sapiens mRNA for mitochondrial import receptor Tom22 variant, clone: HSI14093. AK024731 - Homo sapiens cDNA: FLJ21078 fis, clone CAS02162. AB041906 - Homo sapiens mRNA for Tom22, complete cds. AF163256 - Homo sapiens MSTP065 (MST065) mRNA, complete cds. AB040119 - Homo sapiens mRNA for mitochondrial import receptor Tom22, complete cds. CR456475 - Homo sapiens dJ508I15.5 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ508I15.5). BC009363 - Homo sapiens translocase of outer mitochondrial membrane 22 homolog (yeast), mRNA (cDNA clone MGC:14851 IMAGE:4302531), complete cds. KJ894373 - Synthetic construct Homo sapiens clone ccsbBroadEn_03767 TOMM22 gene, encodes complete protein. AK312076 - Homo sapiens cDNA, FLJ92357, Homo sapiens translocase of outer mitochondrial membrane 22 homolog(yeast) (TOMM22), mRNA. CU013313 - Homo sapiens TOMM22, mRNA (cDNA clone IMAGE:100000091), complete cds, without stop codon, in Gateway system. DQ896289 - Synthetic construct Homo sapiens clone IMAGE:100010749; FLH192966.01L; RZPDo839B0468D translocase of outer mitochondrial membrane 22 homolog (yeast) (TOMM22) gene, encodes complete protein; nuclear gene for mitochondrial product. CU013025 - Homo sapiens TOMM22, mRNA (cDNA clone IMAGE:100000187), complete cds, with stop codon, in Gateway system. DQ893045 - Synthetic construct clone IMAGE:100005675; FLH192970.01X; RZPDo839B0478D translocase of outer mitochondrial membrane 22 homolog (yeast) (TOMM22) gene, encodes complete protein; nuclear gene for mitochondrial product. JD291509 - Sequence 272533 from Patent EP1572962. JD250047 - Sequence 231071 from Patent EP1572962. JD043329 - Sequence 24353 from Patent EP1572962. JD292268 - Sequence 273292 from Patent EP1572962. JD510410 - Sequence 491434 from Patent EP1572962. JD436517 - Sequence 417541 from Patent EP1572962. JD217666 - Sequence 198690 from Patent EP1572962. JD462845 - Sequence 443869 from Patent EP1572962. JD360276 - Sequence 341300 from Patent EP1572962. JD226245 - Sequence 207269 from Patent EP1572962. JD266338 - Sequence 247362 from Patent EP1572962. JD065642 - Sequence 46666 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NS69 (Reactome details) participates in the following event(s):
R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space R-HSA-5205661 Pink1 is recruited from the cytoplasm to the mitochondria R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-392499 Metabolism of proteins R-HSA-5205647 Mitophagy
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
