Human Gene TOMM34 (ENST00000372813.4_7) from GENCODE V47lift37
  Description: translocase of outer mitochondrial membrane 34 (from RefSeq NM_006809.5)
Gencode Transcript: ENST00000372813.4_7
Gencode Gene: ENSG00000025772.8_9
Transcript (Including UTRs)
   Position: hg19 chr20:43,570,771-43,589,038 Size: 18,268 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr20:43,571,750-43,588,974 Size: 17,225 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:43,570,771-43,589,038)mRNA (may differ from genome)Protein (309 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TOM34_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM34; Short=hTom34; AltName: Full=Translocase of outer membrane 34 kDa subunit;
FUNCTION: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
SUBUNIT: Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the Tom34 family.
SIMILARITY: Contains 6 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 133.14 RPKM in Testis
Total median expression: 918.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.9064-0.342 Picture PostScript Text
3' UTR -325.90979-0.333 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF00515 - Tetratricopeptide repeat
PF07719 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
116846 - MIT domain

ModBase Predicted Comparative 3D Structure on Q15785
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0031072 heat shock protein binding

Biological Process:
GO:0006626 protein targeting to mitochondrion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC007423 - Homo sapiens translocase of outer mitochondrial membrane 34, mRNA (cDNA clone MGC:3515 IMAGE:2960090), complete cds.
AB085681 - Homo sapiens URCC3 mRNA, complete cds.
LF383767 - JP 2014500723-A/191270: Polycomb-Associated Non-Coding RNAs.
JD299833 - Sequence 280857 from Patent EP1572962.
JD093577 - Sequence 74601 from Patent EP1572962.
U58970 - Human putative outer mitochondrial membrane 34 kDa translocase hTOM34 mRNA, complete cds.
BC014907 - Homo sapiens translocase of outer mitochondrial membrane 34, mRNA (cDNA clone MGC:17023 IMAGE:3922502), complete cds.
AK000594 - Homo sapiens cDNA FLJ20587 fis, clone KAT09116, highly similar to U58970 Human putative outer mitochondrial membrane 34 kDa.
BC006573 - Homo sapiens cDNA clone IMAGE:3534924, containing frame-shift errors.
AK129538 - Homo sapiens cDNA FLJ26027 fis, clone PNC04328, highly similar to Homo sapiens translocase of outer mitochondrial membrane 34 (TOMM34).
BC001763 - Homo sapiens translocase of outer mitochondrial membrane 34, mRNA (cDNA clone MGC:1252 IMAGE:3544124), complete cds.
AK222952 - Homo sapiens mRNA for translocase of outer mitochondrial membrane 34 variant, clone: HRC11370.
JD521783 - Sequence 502807 from Patent EP1572962.
JD145682 - Sequence 126706 from Patent EP1572962.
JD325977 - Sequence 307001 from Patent EP1572962.
JD547528 - Sequence 528552 from Patent EP1572962.
JD170307 - Sequence 151331 from Patent EP1572962.
JD537619 - Sequence 518643 from Patent EP1572962.
JD289319 - Sequence 270343 from Patent EP1572962.
JD090216 - Sequence 71240 from Patent EP1572962.
JD192955 - Sequence 173979 from Patent EP1572962.
JD317750 - Sequence 298774 from Patent EP1572962.
JD224228 - Sequence 205252 from Patent EP1572962.
JD374303 - Sequence 355327 from Patent EP1572962.
JD466879 - Sequence 447903 from Patent EP1572962.
JD379458 - Sequence 360482 from Patent EP1572962.
JD428201 - Sequence 409225 from Patent EP1572962.
AK307655 - Homo sapiens cDNA, FLJ97603.
JD528919 - Sequence 509943 from Patent EP1572962.
JD072896 - Sequence 53920 from Patent EP1572962.
JD380019 - Sequence 361043 from Patent EP1572962.
JD508731 - Sequence 489755 from Patent EP1572962.
JD530373 - Sequence 511397 from Patent EP1572962.
JD550185 - Sequence 531209 from Patent EP1572962.
AK302128 - Homo sapiens cDNA FLJ54989 complete cds, highly similar to Mitochondrial import receptor subunit TOM34.
JD111905 - Sequence 92929 from Patent EP1572962.
JD382408 - Sequence 363432 from Patent EP1572962.
JD504715 - Sequence 485739 from Patent EP1572962.
CR456765 - Homo sapiens full open reading frame cDNA clone RZPDo834D054D for gene TOMM34, translocase of outer mitochondrial membrane 34; complete cds, incl. stopcodon.
BT020008 - Homo sapiens translocase of outer mitochondrial membrane 34 mRNA, complete cds.
BT020009 - Homo sapiens translocase of outer mitochondrial membrane 34 mRNA, complete cds.
DQ891151 - Synthetic construct clone IMAGE:100003781; FLH169774.01X; RZPDo839F1296D translocase of outer mitochondrial membrane 34 (TOMM34) gene, encodes complete protein; nuclear gene for mitochondrial product.
KJ893177 - Synthetic construct Homo sapiens clone ccsbBroadEn_02571 TOMM34 gene, encodes complete protein.
EU176561 - Synthetic construct Homo sapiens clone IMAGE:100011378; FLH169773.01L; RZPDo839B11253D translocase of outer mitochondrial membrane 34 (TOMM34) gene, encodes complete protein.
AB590243 - Synthetic construct DNA, clone: pFN21AE1568, Homo sapiens TOMM34 gene for translocase of outer mitochondrial membrane 34, without stop codon, in Flexi system.
CU677113 - Synthetic construct Homo sapiens gateway clone IMAGE:100020676 5' read TOMM34 mRNA.
LF350533 - JP 2014500723-A/158036: Polycomb-Associated Non-Coding RNAs.
LF350534 - JP 2014500723-A/158037: Polycomb-Associated Non-Coding RNAs.
JD019489 - Sequence 513 from Patent EP1572962.
JD036287 - Sequence 17311 from Patent EP1572962.
JD451392 - Sequence 432416 from Patent EP1572962.
MA619344 - JP 2018138019-A/191270: Polycomb-Associated Non-Coding RNAs.
MA586110 - JP 2018138019-A/158036: Polycomb-Associated Non-Coding RNAs.
MA586111 - JP 2018138019-A/158037: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000372813.1, ENST00000372813.2, ENST00000372813.3, NM_006809, Q15785, Q53GH9, Q6IBN7, Q9NTZ3, TOM34_HUMAN, uc318kft.1, uc318kft.2, URCC3
UCSC ID: ENST00000372813.4_7
RefSeq Accession: NM_006809.5
Protein: Q15785 (aka TOM34_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.