ID:TOP2A_HUMAN DESCRIPTION: RecName: Full=DNA topoisomerase 2-alpha; EC=5.99.1.3; AltName: Full=DNA topoisomerase II, alpha isozyme; FUNCTION: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA. ENZYME REGULATION: Specifically inhibited by the intercalating agent amsacrine. SUBUNIT: Homodimer. Interacts with COPS5. INTERACTION: P35222:CTNNB1; NbExp=5; IntAct=EBI-539628, EBI-491549; SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm. PTM: Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation. MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. SIMILARITY: Belongs to the type II topoisomerase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00204 - DNA gyrase B PF00521 - DNA gyrase/topoisomerase IV, subunit A PF01751 - Toprim domain PF02518 - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF08070 - DTHCT (NUC029) region PF16898 - C-terminal associated domain of TOPRIM
SCOP Domains: 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like 56719 - Type II DNA topoisomerase
ModBase Predicted Comparative 3D Structure on P11388
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000712 resolution of meiotic recombination intermediates GO:0000819 sister chromatid segregation GO:0002244 hematopoietic progenitor cell differentiation GO:0006259 DNA metabolic process GO:0006265 DNA topological change GO:0006266 DNA ligation GO:0006974 cellular response to DNA damage stimulus GO:0007059 chromosome segregation GO:0030261 chromosome condensation GO:0030263 apoptotic chromosome condensation GO:0040016 embryonic cleavage GO:0042752 regulation of circadian rhythm GO:0043065 positive regulation of apoptotic process GO:0044774 mitotic DNA integrity checkpoint GO:0045070 positive regulation of viral genome replication GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048511 rhythmic process GO:1905463 negative regulation of DNA duplex unwinding
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
