Human Gene TPI1 (ENST00000396705.10_6) from GENCODE V47lift37
  Description: triosephosphate isomerase 1, transcript variant 1 (from RefSeq NM_000365.6)
Gencode Transcript: ENST00000396705.10_6
Gencode Gene: ENSG00000111669.15_9
Transcript (Including UTRs)
   Position: hg19 chr12:6,976,695-6,980,112 Size: 3,418 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr12:6,976,731-6,979,547 Size: 2,817 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:6,976,695-6,980,112)mRNA (may differ from genome)Protein (249 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TPI1
Diseases sorted by gene-association score: hemolytic anemia due to triosephosphate isomerase deficiency* (1667), congenital hemolytic anemia (20), giardiasis (19), phosphoglycerate kinase deficiency (11), molybdenum cofactor deficiency (7), hemolytic anemia (7), visceral leishmaniasis (6), pfeiffer syndrome (6), parasitic protozoa infectious disease (1), leber congenital amaurosis (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 327.35 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 3934.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.0036-0.167 Picture PostScript Text
3' UTR -169.70565-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
    WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  M10036 - Human triosephosphate isomerase mRNA, complete cds.
D28460 - Homo sapiens mRNA for triosephosphate isomerase, 5'UTR region.
BC070129 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:88108 IMAGE:6725406), complete cds.
BC015100 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:22828 IMAGE:3829453), complete cds.
EU794668 - Homo sapiens epididymis secretory protein Li 49 (HEL-S-49) mRNA, complete cds.
AK313282 - Homo sapiens cDNA, FLJ93794, Homo sapiens triosephosphate isomerase 1 (TPI1), mRNA.
AK300661 - Homo sapiens cDNA FLJ52069 complete cds, highly similar to Triosephosphate isomerase (EC 5.3.1.1).
BC007086 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:14696 IMAGE:4244564), complete cds.
AK129488 - Homo sapiens cDNA FLJ25977 fis, clone ADG00662, highly similar to Triosephosphate isomerase (EC 5.3.1.1).
BC017917 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:23862 IMAGE:4296431), complete cds.
BC009885 - Homo sapiens cDNA clone IMAGE:3959863, **** WARNING: chimeric clone ****.
AK222638 - Homo sapiens mRNA for triosephosphate isomerase 1 variant, clone: CBL05173.
BC009329 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:16683 IMAGE:4126160), complete cds.
BC011611 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:11372 IMAGE:3956298), complete cds.
BC007812 - Homo sapiens triosephosphate isomerase 1, mRNA (cDNA clone MGC:14348 IMAGE:4298901), complete cds.
AB590181 - Synthetic construct DNA, clone: pFN21AE1370, Homo sapiens TPI1 gene for triosephosphate isomerase 1, without stop codon, in Flexi system.
DQ893249 - Synthetic construct clone IMAGE:100005879; FLH195612.01X; RZPDo839E04152D triosephosphate isomerase 1 (TPI1) gene, encodes complete protein.
DQ896578 - Synthetic construct Homo sapiens clone IMAGE:100011038; FLH195608.01L; RZPDo839E04151D triosephosphate isomerase 1 (TPI1) gene, encodes complete protein.
KJ905943 - Synthetic construct Homo sapiens clone ccsbBroadEn_15613 TPI1 gene, encodes complete protein.
KJ892307 - Synthetic construct Homo sapiens clone ccsbBroadEn_01701 TPI1 gene, encodes complete protein.
KR710097 - Synthetic construct Homo sapiens clone CCSBHm_00009620 TPI1 (TPI1) mRNA, encodes complete protein.
KR710098 - Synthetic construct Homo sapiens clone CCSBHm_00009623 TPI1 (TPI1) mRNA, encodes complete protein.
KR710099 - Synthetic construct Homo sapiens clone CCSBHm_00009627 TPI1 (TPI1) mRNA, encodes complete protein.
KR710100 - Synthetic construct Homo sapiens clone CCSBHm_00009630 TPI1 (TPI1) mRNA, encodes complete protein.
CR541702 - Homo sapiens full open reading frame cDNA clone RZPDo834H0728D for gene TPI1, triosephosphate isomerase 1; complete cds, without stopcodon.
AK298809 - Homo sapiens cDNA FLJ55297 complete cds, highly similar to Triosephosphate isomerase (EC 5.3.1.1).
DQ599712 - Homo sapiens piRNA piR-37778, complete sequence.
BC017165 - Homo sapiens, Similar to triosephosphate isomerase 1, clone IMAGE:3909707, mRNA, partial cds.
JD023540 - Sequence 4564 from Patent EP1572962.
JD048005 - Sequence 29029 from Patent EP1572962.
JD092766 - Sequence 73790 from Patent EP1572962.
JD022511 - Sequence 3535 from Patent EP1572962.
JD208309 - Sequence 189333 from Patent EP1572962.
JD126403 - Sequence 107427 from Patent EP1572962.
JD188767 - Sequence 169791 from Patent EP1572962.
JD026969 - Sequence 7993 from Patent EP1572962.
JD029404 - Sequence 10428 from Patent EP1572962.
JD354990 - Sequence 336014 from Patent EP1572962.
JD086464 - Sequence 67488 from Patent EP1572962.
JD099273 - Sequence 80297 from Patent EP1572962.
JD089406 - Sequence 70430 from Patent EP1572962.
JD230439 - Sequence 211463 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY66-373 - sucrose degradation
PWY66-399 - gluconeogenesis
PWY66-400 - glycolysis
PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000396705.1, ENST00000396705.2, ENST00000396705.3, ENST00000396705.4, ENST00000396705.5, ENST00000396705.6, ENST00000396705.7, ENST00000396705.8, ENST00000396705.9, HEL-S-49 , NM_000365, uc318ylg.1, uc318ylg.2, V9HWK1, V9HWK1_HUMAN
UCSC ID: ENST00000396705.10_6
RefSeq Accession: NM_000365.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.