Human Gene TPT1 (ENST00000530705.6_7) from GENCODE V47lift37
  Description: tumor protein, translationally-controlled 1, transcript variant 2 (from RefSeq NM_003295.4)
Gencode Transcript: ENST00000530705.6_7
Gencode Gene: ENSG00000133112.17_8
Transcript (Including UTRs)
   Position: hg19 chr13:45,907,606-45,915,318 Size: 7,713 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr13:45,911,521-45,915,204 Size: 3,684 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:45,907,606-45,915,318)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TCTP_HUMAN
DESCRIPTION: RecName: Full=Translationally-controlled tumor protein; Short=TCTP; AltName: Full=Fortilin; AltName: Full=Histamine-releasing factor; Short=HRF; AltName: Full=p23;
FUNCTION: Involved in calcium binding and microtubule stabilization.
SUBUNIT: Interacts with STEAP3.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection.
SIMILARITY: Belongs to the TCTP family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TPT1
Diseases sorted by gene-association score: urticaria (5), asthma (3), allergic hypersensitivity disease (3), paraneoplastic cerebellar degeneration (2), mycetoma (2), periodic fever, familial (2), posterior myocardial infarction (2), branch retinal artery occlusion (1), eumycotic mycetoma (1), malaria (1), leukocoria (1), dirofilariasis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2669.80 RPKM in Muscle - Skeletal
Total median expression: 48043.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.10114-0.255 Picture PostScript Text
3' UTR -1291.403915-0.330 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011057 - Mss4-like
IPR011323 - Mss4/transl-control_tumor
IPR018103 - Translation_control_tumour_CS
IPR018105 - Translational_control_tumour_p

Pfam Domains:
PF00838 - Translationally controlled tumour protein

SCOP Domains:
51316 - Mss4-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YZ1 - X-ray MuPIT 2HR9 - NMR MuPIT 3EBM - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P13693
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGD  WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding

Biological Process:
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0009615 response to virus
GO:0030154 cell differentiation
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component:
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:0045298 tubulin complex


-  Descriptions from all associated GenBank mRNAs
  JD072658 - Sequence 53682 from Patent EP1572962.
JD444664 - Sequence 425688 from Patent EP1572962.
JD466750 - Sequence 447774 from Patent EP1572962.
JD212214 - Sequence 193238 from Patent EP1572962.
BC022436 - Homo sapiens tumor protein, translationally-controlled 1, mRNA (cDNA clone MGC:24736 IMAGE:4281364), complete cds.
JD314721 - Sequence 295745 from Patent EP1572962.
JD020017 - Sequence 1041 from Patent EP1572962.
JD029567 - Sequence 10591 from Patent EP1572962.
JD027221 - Sequence 8245 from Patent EP1572962.
JD036697 - Sequence 17721 from Patent EP1572962.
X16064 - Human mRNA for translationally controlled tumor protein.
L13806 - Homo sapiens (clone 04) translationally controlled tumor protein mRNA, 3' end.
BC012431 - Homo sapiens tumor protein, translationally-controlled 1, mRNA (cDNA clone MGC:9981 IMAGE:3880559), complete cds.
X64899 - H.sapiens mRNA homologous to mouse P21 mRNA.
BC040008 - Homo sapiens tumor protein, translationally-controlled 1, mRNA (cDNA clone IMAGE:5219529), complete cds.
BC003352 - Homo sapiens tumor protein, translationally-controlled 1, mRNA (cDNA clone MGC:5308 IMAGE:2899964), complete cds.
BC052333 - Homo sapiens tumor protein, translationally-controlled 1, mRNA (cDNA clone MGC:61507 IMAGE:6058799), complete cds.
AK130847 - Homo sapiens cDNA FLJ27337 fis, clone TMS09488, highly similar to Translationally controlled tumor protein.
AK296587 - Homo sapiens cDNA FLJ57738 complete cds, highly similar to Translationally-controlled tumor protein.
AY117678 - Homo sapiens p02 protein mRNA, complete cds.
JD085423 - Sequence 66447 from Patent EP1572962.
JD159982 - Sequence 141006 from Patent EP1572962.
KJ901806 - Synthetic construct Homo sapiens clone ccsbBroadEn_11200 TPT1 gene, encodes complete protein.
AY334563 - Homo sapiens cell-type eosinophil TCTP mRNA, complete cds.
CR457036 - Homo sapiens full open reading frame cDNA clone RZPDo834D0415D for gene TPT1, tumor protein, translationally-controlled 1; complete cds, incl. stopcodon.
CU680324 - Synthetic construct Homo sapiens gateway clone IMAGE:100020621 5' read TPT1 mRNA.
JF432827 - Synthetic construct Homo sapiens clone IMAGE:100074146 tumor protein, translationally-controlled 1 (TPT1) gene, encodes complete protein.
KJ892312 - Synthetic construct Homo sapiens clone ccsbBroadEn_01706 TPT1 gene, encodes complete protein.
KJ892313 - Synthetic construct Homo sapiens clone ccsbBroadEn_01707 TPT1 gene, encodes complete protein.
AK312951 - Homo sapiens cDNA, FLJ93407, Homo sapiens tumor protein, translationally-controlled 1 (TPT1),mRNA.
CU692614 - Synthetic construct Homo sapiens gateway clone IMAGE:100022050 5' read TPT1 mRNA.
AK296952 - Homo sapiens cDNA FLJ57742 complete cds.
DL491334 - Novel nucleic acids.
DL489966 - Novel nucleic acids.
D28408 - Homo sapiens mRNA for translationally controlled tumor protein, 5'UTR region.
JD337276 - Sequence 318300 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7E5, ENST00000530705.1, ENST00000530705.2, ENST00000530705.3, ENST00000530705.4, ENST00000530705.5, NM_003295, P13693, Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70, TCTP_HUMAN, uc324hue.1, uc324hue.2
UCSC ID: ENST00000530705.6_7
RefSeq Accession: NM_003295.4
Protein: P13693 (aka TCTP_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.