ID:TCTP_HUMAN DESCRIPTION: RecName: Full=Translationally-controlled tumor protein; Short=TCTP; AltName: Full=Fortilin; AltName: Full=Histamine-releasing factor; Short=HRF; AltName: Full=p23; FUNCTION: Involved in calcium binding and microtubule stabilization. SUBUNIT: Interacts with STEAP3. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate. INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection. SIMILARITY: Belongs to the TCTP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13693
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0009615 response to virus GO:0030154 cell differentiation GO:0042981 regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage