Human Gene TRABD (ENST00000303434.8_6) from GENCODE V47lift37
  Description: TraB domain containing, transcript variant 2 (from RefSeq NM_025204.4)
Gencode Transcript: ENST00000303434.8_6
Gencode Gene: ENSG00000170638.10_10
Transcript (Including UTRs)
   Position: hg19 chr22:50,624,346-50,638,027 Size: 13,682 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr22:50,631,490-50,636,948 Size: 5,459 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:50,624,346-50,638,027)mRNA (may differ from genome)Protein (376 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRABD_HUMAN
DESCRIPTION: RecName: Full=TraB domain-containing protein; AltName: Full=Protein TTG2;
SEQUENCE CAUTION: Sequence=BAB15737.1; Type=Frameshift; Positions=224, 282;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.91 RPKM in Whole Blood
Total median expression: 1322.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.90119-0.520 Picture PostScript Text
3' UTR -481.901079-0.447 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002816 - Pheromone_shutdown_TraB

Pfam Domains:
PF01963 - TraB/PrgY/gumN family

ModBase Predicted Comparative 3D Structure on Q9H4I3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Descriptions from all associated GenBank mRNAs
  BC093029 - Homo sapiens TraB domain containing, mRNA (cDNA clone MGC:110928 IMAGE:30527560), complete cds.
BC012445 - Homo sapiens TraB domain containing, mRNA (cDNA clone MGC:9367 IMAGE:3857552), complete cds.
AL449244 - Novel human gene mapping to chomosome 22.
DQ529300 - Homo sapiens TTG2 (TTG2) gene, TTG2-s allele, complete cds.
AK292050 - Homo sapiens cDNA FLJ77505 complete cds.
AY203945 - Homo sapiens LP6054 mRNA, complete cds.
KJ903296 - Synthetic construct Homo sapiens clone ccsbBroadEn_12690 TRABD gene, encodes complete protein.
AK024447 - Homo sapiens mRNA for FLJ00037 protein, partial cds.
AF218001 - Homo sapiens clone PP2447 unknown mRNA.
JD424075 - Sequence 405099 from Patent EP1572962.
JD378738 - Sequence 359762 from Patent EP1572962.
JD472057 - Sequence 453081 from Patent EP1572962.
JD102741 - Sequence 83765 from Patent EP1572962.
DQ587927 - Homo sapiens piRNA piR-55039, complete sequence.
JD442895 - Sequence 423919 from Patent EP1572962.
JD537138 - Sequence 518162 from Patent EP1572962.
JD345327 - Sequence 326351 from Patent EP1572962.
JD192016 - Sequence 173040 from Patent EP1572962.
JD425654 - Sequence 406678 from Patent EP1572962.
JD390515 - Sequence 371539 from Patent EP1572962.
DQ590600 - Homo sapiens piRNA piR-57712, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000303434.1, ENST00000303434.2, ENST00000303434.3, ENST00000303434.4, ENST00000303434.5, ENST00000303434.6, ENST00000303434.7, NM_025204, PP2447, Q19CC5, Q96ED8, Q9H4I3, Q9H7N1, Q9UGX6, Q9UGX7, TRABD_HUMAN, TTG2, uc317nfw.1, uc317nfw.2
UCSC ID: ENST00000303434.8_6
RefSeq Accession: NM_025204.4
Protein: Q9H4I3 (aka TRABD_HUMAN or TRAB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.