ID:TRAF4_HUMAN DESCRIPTION: RecName: Full=TNF receptor-associated factor 4; AltName: Full=Cysteine-rich domain associated with RING and Traf domains protein 1; AltName: Full=Metastatic lymph node gene 62 protein; Short=MLN 62; AltName: Full=RING finger protein 83; FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. SUBUNIT: Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6. INTERACTION: P07174:Ngfr (xeno); NbExp=3; IntAct=EBI-3650647, EBI-1038810; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton (Probable). TISSUE SPECIFICITY: Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. INDUCTION: Up-regulated by bacterial lipopolysaccharides (LPS) and by single-stranded CpG oligodeoxynucleotide. DOMAIN: The coiled coil domain mediates homo- and hetero- oligomerization (By similarity). DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity). PTM: Polyubiquitinated, leading to its proteasomal degradation. SIMILARITY: Belongs to the TNF receptor-associated factor family. B subfamily. SIMILARITY: Contains 1 MATH domain. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 3 TRAF-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TRAF4ID204.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/traf4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BUZ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0007165 signal transduction GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0007275 multicellular organism development GO:0007585 respiratory gaseous exchange GO:0030323 respiratory tube development GO:0042981 regulation of apoptotic process GO:0045860 positive regulation of protein kinase activity GO:0046330 positive regulation of JNK cascade GO:0090073 positive regulation of protein homodimerization activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
