Human Gene TREML2 (ENST00000483722.2_7) from GENCODE V47lift37
  Description: triggering receptor expressed on myeloid cells like 2 (from RefSeq NM_024807.4)
Gencode Transcript: ENST00000483722.2_7
Gencode Gene: ENSG00000112195.9_9
Transcript (Including UTRs)
   Position: hg19 chr6:41,157,487-41,168,887 Size: 11,401 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr6:41,160,165-41,168,746 Size: 8,582 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:41,157,487-41,168,887)mRNA (may differ from genome)Protein (321 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRML2_HUMAN
DESCRIPTION: RecName: Full=Trem-like transcript 2 protein; Short=TLT-2; AltName: Full=Triggering receptor expressed on myeloid cells-like protein 2; Flags: Precursor;
FUNCTION: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
SUBUNIT: Interacts with CD276 and this interaction enhances T-cell activation.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
INDUCTION: Induced in CD4 T-cells by concanavalin-A.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SEQUENCE CAUTION: Sequence=AAI25079.1; Type=Erroneous initiation; Sequence=AAI25080.1; Type=Erroneous initiation; Sequence=BAB14668.1; Type=Erroneous initiation; Sequence=CAI19858.1; Type=Erroneous initiation; Sequence=CAI19909.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.29 RPKM in Whole Blood
Total median expression: 35.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.10141-0.355 Picture PostScript Text
3' UTR -1003.302678-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q5T2D2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0038023 signaling receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0042110 T cell activation
GO:0050776 regulation of immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AJ420509 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2021936.
AK023755 - Homo sapiens cDNA FLJ13693 fis, clone PLACE2000111.
JD546652 - Sequence 527676 from Patent EP1572962.
JD373445 - Sequence 354469 from Patent EP1572962.
JD468410 - Sequence 449434 from Patent EP1572962.
JD332848 - Sequence 313872 from Patent EP1572962.
JD176083 - Sequence 157107 from Patent EP1572962.
JD531602 - Sequence 512626 from Patent EP1572962.
JD419184 - Sequence 400208 from Patent EP1572962.
JD224361 - Sequence 205385 from Patent EP1572962.
JD225148 - Sequence 206172 from Patent EP1572962.
JD316719 - Sequence 297743 from Patent EP1572962.
JD437963 - Sequence 418987 from Patent EP1572962.
JD558032 - Sequence 539056 from Patent EP1572962.
JD063459 - Sequence 44483 from Patent EP1572962.
JD205107 - Sequence 186131 from Patent EP1572962.
JD339646 - Sequence 320670 from Patent EP1572962.
JD244122 - Sequence 225146 from Patent EP1572962.
JD047948 - Sequence 28972 from Patent EP1572962.
JD355353 - Sequence 336377 from Patent EP1572962.
JD283072 - Sequence 264096 from Patent EP1572962.
JD207285 - Sequence 188309 from Patent EP1572962.
JD135278 - Sequence 116302 from Patent EP1572962.
JD241107 - Sequence 222131 from Patent EP1572962.
JD067392 - Sequence 48416 from Patent EP1572962.
JD201723 - Sequence 182747 from Patent EP1572962.
JD213910 - Sequence 194934 from Patent EP1572962.
JD415350 - Sequence 396374 from Patent EP1572962.
JD320761 - Sequence 301785 from Patent EP1572962.
JD174643 - Sequence 155667 from Patent EP1572962.
JD400582 - Sequence 381606 from Patent EP1572962.
JD375543 - Sequence 356567 from Patent EP1572962.
JD440420 - Sequence 421444 from Patent EP1572962.
BC125078 - Homo sapiens triggering receptor expressed on myeloid cells-like 2, mRNA (cDNA clone MGC:149715 IMAGE:40117710), complete cds.
BC125079 - Homo sapiens triggering receptor expressed on myeloid cells-like 2, mRNA (cDNA clone MGC:149716 IMAGE:40117711), complete cds.
JD483935 - Sequence 464959 from Patent EP1572962.
JD279159 - Sequence 260183 from Patent EP1572962.
JD114923 - Sequence 95947 from Patent EP1572962.
JD518336 - Sequence 499360 from Patent EP1572962.
JD218127 - Sequence 199151 from Patent EP1572962.
JD100620 - Sequence 81644 from Patent EP1572962.
JD456697 - Sequence 437721 from Patent EP1572962.
JD157515 - Sequence 138539 from Patent EP1572962.
JD193408 - Sequence 174432 from Patent EP1572962.
JD217073 - Sequence 198097 from Patent EP1572962.
JD404002 - Sequence 385026 from Patent EP1572962.
JD502102 - Sequence 483126 from Patent EP1572962.
JD246606 - Sequence 227630 from Patent EP1572962.
JD484150 - Sequence 465174 from Patent EP1572962.
JD484651 - Sequence 465675 from Patent EP1572962.
JD468179 - Sequence 449203 from Patent EP1572962.
JD278878 - Sequence 259902 from Patent EP1572962.
JD484453 - Sequence 465477 from Patent EP1572962.
JD485485 - Sequence 466509 from Patent EP1572962.
JD123178 - Sequence 104202 from Patent EP1572962.
AY358171 - Homo sapiens clone DNA163134 APAF6268 (UNQ6268) mRNA, complete cds.
JD320983 - Sequence 302007 from Patent EP1572962.
JD065657 - Sequence 46681 from Patent EP1572962.
JD122065 - Sequence 103089 from Patent EP1572962.
AF534824 - Homo sapiens TREM-like transcript 2 (TLT2) mRNA, complete cds.
KJ899579 - Synthetic construct Homo sapiens clone ccsbBroadEn_08973 TREML2 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5T2D2 (Reactome details) participates in the following event(s):

R-HSA-5696358 TREM,CD300 binds lipids
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf76, ENST00000483722.1, NM_024807, Q08AP8, Q08AP9, Q5T2D2, Q8IWY0, Q9H8E9, TLT2, TRML2_HUMAN, uc322dfo.1, uc322dfo.2, UNQ6268/PRO20473
UCSC ID: ENST00000483722.2_7
RefSeq Accession: NM_024807.4
Protein: Q5T2D2 (aka TRML2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.