Human Gene TRIB1 (ENST00000311922.4_4) from GENCODE V47lift37
  Description: tribbles pseudokinase 1, transcript variant 1 (from RefSeq NM_025195.4)
Gencode Transcript: ENST00000311922.4_4
Gencode Gene: ENSG00000173334.4_7
Transcript (Including UTRs)
   Position: hg19 chr8:126,442,600-126,450,645 Size: 8,046 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr8:126,443,145-126,448,713 Size: 5,569 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:126,442,600-126,450,645)mRNA (may differ from genome)Protein (372 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRIB1_HUMAN
DESCRIPTION: RecName: Full=Tribbles homolog 1; Short=TRB-1; AltName: Full=G-protein-coupled receptor-induced gene 2 protein; Short=GIG-2; AltName: Full=SKIP1;
FUNCTION: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.
TISSUE SPECIFICITY: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TRIB1
Diseases sorted by gene-association score: megakaryocytic leukemia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.66 RPKM in Thyroid
Total median expression: 411.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -250.60545-0.460 Picture PostScript Text
3' UTR -526.101932-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR024104 - Tribbles/Ser_Thr_kinase_40
IPR024105 - Tribbles_TRB1

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q96RU8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0055106 ubiquitin-protein transferase regulator activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006469 negative regulation of protein kinase activity
GO:0007254 JNK cascade
GO:0014912 negative regulation of smooth muscle cell migration
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032496 response to lipopolysaccharide
GO:0043405 regulation of MAP kinase activity
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045645 positive regulation of eosinophil differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045659 negative regulation of neutrophil differentiation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0006468 protein phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF210282 - JP 2014500723-A/17785: Polycomb-Associated Non-Coding RNAs.
LF210283 - JP 2014500723-A/17786: Polycomb-Associated Non-Coding RNAs.
BC063292 - Homo sapiens tribbles homolog 1 (Drosophila), mRNA (cDNA clone MGC:71615 IMAGE:30343492), complete cds.
AF250310 - Homo sapiens SKIP1 mRNA, complete cds.
AF205437 - Homo sapiens G-protein-coupled receptor induced protein GIG2 (GIG2) mRNA, complete cds.
AL832388 - Homo sapiens mRNA; cDNA DKFZp667H1412 (from clone DKFZp667H1412).
JD257809 - Sequence 238833 from Patent EP1572962.
JD144457 - Sequence 125481 from Patent EP1572962.
JD188716 - Sequence 169740 from Patent EP1572962.
JD365714 - Sequence 346738 from Patent EP1572962.
AB385147 - Synthetic construct DNA, clone: pF1KB5662, Homo sapiens TRIB1 gene for tribbles homolog 1, complete cds, without stop codon, in Flexi system.
KJ898175 - Synthetic construct Homo sapiens clone ccsbBroadEn_07569 TRIB1 gene, encodes complete protein.
LF213366 - JP 2014500723-A/20869: Polycomb-Associated Non-Coding RNAs.
AK297539 - Homo sapiens cDNA FLJ61135 complete cds, highly similar to Tribbles homolog 1.
AJ000480 - Homo sapiens mRNA for C8FW phosphoprotein.
AK307561 - Homo sapiens cDNA, FLJ97509.
LF336823 - JP 2014500723-A/144326: Polycomb-Associated Non-Coding RNAs.
BC012441 - Homo sapiens tribbles homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:3882871), partial cds.
JD348269 - Sequence 329293 from Patent EP1572962.
JD037007 - Sequence 18031 from Patent EP1572962.
JD222849 - Sequence 203873 from Patent EP1572962.
AK001319 - Homo sapiens cDNA FLJ10457 fis, clone NT2RP1001424.
AK022787 - Homo sapiens cDNA FLJ12725 fis, clone NT2RP1001432.
JD244472 - Sequence 225496 from Patent EP1572962.
JD282470 - Sequence 263494 from Patent EP1572962.
JD102989 - Sequence 84013 from Patent EP1572962.
JD206225 - Sequence 187249 from Patent EP1572962.
JD180818 - Sequence 161842 from Patent EP1572962.
JD494806 - Sequence 475830 from Patent EP1572962.
JD153845 - Sequence 134869 from Patent EP1572962.
JD201229 - Sequence 182253 from Patent EP1572962.
JD430035 - Sequence 411059 from Patent EP1572962.
JD516864 - Sequence 497888 from Patent EP1572962.
JD413591 - Sequence 394615 from Patent EP1572962.
JD217912 - Sequence 198936 from Patent EP1572962.
JD147020 - Sequence 128044 from Patent EP1572962.
JD360603 - Sequence 341627 from Patent EP1572962.
LF336824 - JP 2014500723-A/144327: Polycomb-Associated Non-Coding RNAs.
JD166240 - Sequence 147264 from Patent EP1572962.
JD350329 - Sequence 331353 from Patent EP1572962.
JD111863 - Sequence 92887 from Patent EP1572962.
LF336825 - JP 2014500723-A/144328: Polycomb-Associated Non-Coding RNAs.
JD531718 - Sequence 512742 from Patent EP1572962.
MA445859 - JP 2018138019-A/17785: Polycomb-Associated Non-Coding RNAs.
MA445860 - JP 2018138019-A/17786: Polycomb-Associated Non-Coding RNAs.
MA448943 - JP 2018138019-A/20869: Polycomb-Associated Non-Coding RNAs.
MA572400 - JP 2018138019-A/144326: Polycomb-Associated Non-Coding RNAs.
MA572401 - JP 2018138019-A/144327: Polycomb-Associated Non-Coding RNAs.
MA572402 - JP 2018138019-A/144328: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DMM6, C5HU08, C8FW , ENST00000311922.1, ENST00000311922.2, ENST00000311922.3, GIG2 , NM_025195, O15180, Q96RU8, Q9H2Y8, TRB1, TRIB1 , TRIB1_HUMAN, uc317pco.1, uc317pco.2
UCSC ID: ENST00000311922.4_4
RefSeq Accession: NM_025195.4
Protein: Q96RU8 (aka TRIB1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.