ID:TRIB2_HUMAN DESCRIPTION: RecName: Full=Tribbles homolog 2; Short=TRB-2; FUNCTION: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=May associate with the cytoskeleton (By similarity). TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes. MISCELLANEOUS: Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q92519
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004860 protein kinase inhibitor activity GO:0008134 transcription factor binding GO:0031434 mitogen-activated protein kinase kinase binding GO:0031625 ubiquitin protein ligase binding GO:0055106 ubiquitin-protein transferase regulator activity GO:0000166 nucleotide binding GO:0004672 protein kinase activity
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043405 regulation of MAP kinase activity GO:0045081 negative regulation of interleukin-10 biosynthetic process GO:0045599 negative regulation of fat cell differentiation GO:0006468 protein phosphorylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
