Human Gene TRIM54 (ENST00000380075.7_7) from GENCODE V47lift37
  Description: tripartite motif containing 54, transcript variant 2 (from RefSeq NM_187841.3)
Gencode Transcript: ENST00000380075.7_7
Gencode Gene: ENSG00000138100.14_9
Transcript (Including UTRs)
   Position: hg19 chr2:27,505,297-27,530,303 Size: 25,007 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr2:27,505,600-27,529,409 Size: 23,810 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:27,505,297-27,530,303)mRNA (may differ from genome)Protein (358 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRI54_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 54; AltName: Full=Muscle-specific RING finger protein; Short=MuRF; AltName: Full=Muscle-specific RING finger protein 3; Short=MuRF-3; Short=MuRF3; AltName: Full=RING finger protein 30;
FUNCTION: May bind and stabilize microtubules during myotubes formation (By similarity).
SUBUNIT: Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).
TISSUE SPECIFICITY: Specifically expressed in heart and skeletal muscle.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 COS domain.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAY24296.1; Type=Erroneous initiation; Sequence=CAC32841.1; Type=Erroneous initiation; Sequence=CAC32842.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM54
Diseases sorted by gene-association score: cardiac rupture (7), cardiomyopathy, familial hypertrophic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 219.32 RPKM in Muscle - Skeletal
Total median expression: 430.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.40303-0.242 Picture PostScript Text
3' UTR -232.70550-0.423 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017903 - COS_domain
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00643 - B-box zinc finger
PF13445 - RING-type zinc-finger
PF13639 - Ring finger domain
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF14634 - zinc-RING finger domain

SCOP Domains:
57845 - B-box zinc-binding domain
57850 - RING/U-box

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3Q1D - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BYV2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0007017 microtubule-based process
GO:0007026 negative regulation of microtubule depolymerization
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
GO:0055001 muscle cell development
GO:0070507 regulation of microtubule cytoskeleton organization

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030018 Z disc


-  Descriptions from all associated GenBank mRNAs
  AK300699 - Homo sapiens cDNA FLJ60896 complete cds, highly similar to Tripartite motif-containing protein 54.
AK311516 - Homo sapiens cDNA, FLJ18558.
BC141807 - Homo sapiens tripartite motif-containing 54, mRNA (cDNA clone MGC:164792 IMAGE:40147443), complete cds.
AJ291714 - Homo sapiens mRNA for RNF30 gene for ring finger protein 30.

-  Other Names for This Gene
  Alternate Gene Symbols: A5D8T7, ENST00000380075.1, ENST00000380075.2, ENST00000380075.3, ENST00000380075.4, ENST00000380075.5, ENST00000380075.6, MURF, MURF3, NM_187841, Q53SY4, Q9BYV2, Q9BYV3, RNF30, TRI54_HUMAN, uc318pjh.1, uc318pjh.2
UCSC ID: ENST00000380075.7_7
RefSeq Accession: NM_187841.3
Protein: Q9BYV2 (aka TRI54_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.