ID:T22D3_HUMAN DESCRIPTION: RecName: Full=TSC22 domain family protein 3; AltName: Full=DSIP-immunoreactive peptide; Short=Protein DIP; Short=hDIP; AltName: Full=Delta sleep-inducing peptide immunoreactor; AltName: Full=Glucocorticoid-induced leucine zipper protein; Short=GILZ; AltName: Full=TSC-22-like protein; AltName: Full=TSC-22-related protein; Short=TSC-22R; FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). SUBUNIT: Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. TISSUE SPECIFICITY: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down- regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells. INDUCTION: By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. DOMAIN: The leucine-zipper is involved in homodimerization (By similarity). SIMILARITY: Belongs to the TSC-22/Dip/Bun family. SEQUENCE CAUTION: Sequence=AAH18148.3; Type=Erroneous initiation; Sequence=CAA90644.1; Type=Erroneous initiation; Sequence=CAB53669.1; Type=Frameshift; Positions=4;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99576
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043426 MRF binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006355 regulation of transcription, DNA-templated GO:0006970 response to osmotic stress GO:0034220 ion transmembrane transport GO:0048642 negative regulation of skeletal muscle tissue development GO:0070236 negative regulation of activation-induced cell death of T cells
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
