Human Gene TSHR (ENST00000298171.7_4) from GENCODE V47lift37
  Description: thyroid stimulating hormone receptor, transcript variant 1 (from RefSeq NM_000369.5)
Gencode Transcript: ENST00000298171.7_4
Gencode Gene: ENSG00000165409.18_9
Transcript (Including UTRs)
   Position: hg19 chr14:81,421,965-81,612,650 Size: 190,686 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr14:81,422,025-81,610,697 Size: 188,673 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:81,421,965-81,612,650)mRNA (may differ from genome)Protein (764 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TSHR
Diseases sorted by gene-association score: hypothyroidism, congenital, nongoitrous, 1* (1670), hyperthyroidism, familial gestational* (1669), hyperthyroidism, nonautoimmune* (1650), familial hyperthyroidism due to mutations in tsh receptor* (400), hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia* (261), athyreosis* (260), visual epilepsy* (107), seizure disorder* (107), thyroid carcinoma with thyrotoxicosis* (100), hyperthyroidism (72), multinodular goiter (46), myxedema (46), hypothyroidism (44), graves' disease (35), neonatal thyrotoxicosis (32), goiter (23), exophthalmos (22), thyroiditis (19), hashimoto thyroiditis (16), thyroid cancer (16), chronic orbital inflammation (15), benign struma ovarii (15), autoimmune disease of endocrine system (14), thyroid gland disease (14), congenital hypothyroidism (12), subacute thyroiditis (12), nodular goiter (11), thyroid cancer, nonmedullary, 1 (11), thyroid cancer, nonmedullary, 2 (11), papillary carcinoma (11), endemic goiter (11), orbital plasma cell granuloma (10), graves disease 1 (10), nontoxic goiter (9), thymic hyperplasia (9), struma ovarii (8), neonatal hypothyroidism (8), orbital disease (8), follicular adenoma (6), toxic diffuse goiter (6), alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity (6), ovarian germ cell teratoma (6), thyrotoxic periodic paralysis (6), ethylmalonic encephalopathy (5), hypersensitivity reaction disease (5), hypersensitivity reaction type ii disease (4), differentiated thyroid carcinoma (3), eye disease (1), immune system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.44 RPKM in Thyroid
Total median expression: 88.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.1060-0.185 Picture PostScript Text
3' UTR -450.301953-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK303378 - Homo sapiens cDNA FLJ56543 complete cds, highly similar to Thyrotropin receptor precursor.
BC024205 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:3030349), complete cds.
M31774 - Human thyrotropin receptor (TSH) mRNA, complete cds.
BC108653 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:3860072), complete cds.
BC009237 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:2989823), complete cds.
M73747 - Homo sapiens thyroid stimulating hormone receptor (TSHR) mRNA, complete cds.
A34990 - H.sapiens TSH receptor.
M32215 - Human thyroid stimulatory hormone receptor (TSHR) mRNA, complete cds.
BC063613 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:3860379), complete cds.
AB209207 - Homo sapiens mRNA for thyroid stimulating hormone receptor variant protein.
BC120972 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:40115462), complete cds.
BC120973 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:40115463), complete cds.
BC141970 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:40115470), complete cds.
BC127628 - Homo sapiens thyroid stimulating hormone receptor, mRNA (cDNA clone IMAGE:40115464), complete cds.
BC127629 - Homo sapiens cDNA clone IMAGE:40115466, containing frame-shift errors.
S49816 - thyrotropin receptor-I {alternatively spliced} [human, thyroid, mRNA, 793 nt].
CU687778 - Synthetic construct Homo sapiens gateway clone IMAGE:100021590 5' read TSHR mRNA.
S45272 - thyrotropin receptor [human, thyroid tissue, mRNA Partial Mutant, 1045 nt].
AB384880 - Synthetic construct DNA, clone: pF1KB3965, Homo sapiens TSHR gene for thyrotropin receptor precursor, complete cds, without stop codon, in Flexi system.
AY429111 - Homo sapiens thyroid stimulating hormone receptor mRNA, complete cds.
BC156779 - Synthetic construct Homo sapiens clone IMAGE:100062266, MGC:190224 thyroid stimulating hormone receptor (TSHR) mRNA, encodes complete protein.
HQ448048 - Synthetic construct Homo sapiens clone IMAGE:100071427; CCSB012039_02 thyroid stimulating hormone receptor (TSHR) gene, encodes complete protein.
KJ892323 - Synthetic construct Homo sapiens clone ccsbBroadEn_01717 TSHR gene, encodes complete protein.
KJ897710 - Synthetic construct Homo sapiens clone ccsbBroadEn_07104 TSHR gene, encodes complete protein.
KR711103 - Synthetic construct Homo sapiens clone CCSBHm_00020319 TSHR (TSHR) mRNA, encodes complete protein.
KR711104 - Synthetic construct Homo sapiens clone CCSBHm_00020321 TSHR (TSHR) mRNA, encodes complete protein.
KR711105 - Synthetic construct Homo sapiens clone CCSBHm_00020323 TSHR (TSHR) mRNA, encodes complete protein.
KR711106 - Synthetic construct Homo sapiens clone CCSBHm_00020326 TSHR (TSHR) mRNA, encodes complete protein.
MB483350 - JP 2019528312-A/11: MRNA-MEDIATED IMMUNIZATION METHODS.
JD544465 - Sequence 525489 from Patent EP1572962.
AK095769 - Homo sapiens cDNA FLJ38450 fis, clone FEBRA2019457.
AF035261 - Homo sapiens thyroid stimulating hormone receptor (TSHR) mRNA, partial cds.
S82807 - thyrotropin receptor {3' region} [human, mRNA Partial, 1573 nt].

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MTJ0, A0A0A0MTJ0_HUMAN, ENST00000298171.1, ENST00000298171.2, ENST00000298171.3, ENST00000298171.4, ENST00000298171.5, ENST00000298171.6, NM_000369, TSHR , uc317mdg.1, uc317mdg.2
UCSC ID: ENST00000298171.7_4
RefSeq Accession: NM_000369.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.