Human Gene TSLP (ENST00000344895.4_8) from GENCODE V47lift37
  Description: thymic stromal lymphopoietin, transcript variant 1 (from RefSeq NM_033035.5)
Gencode Transcript: ENST00000344895.4_8
Gencode Gene: ENSG00000145777.15_11
Transcript (Including UTRs)
   Position: hg19 chr5:110,407,411-110,413,724 Size: 6,314 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr5:110,407,589-110,411,772 Size: 4,184 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:110,407,411-110,413,724)mRNA (may differ from genome)Protein (159 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TSLP_HUMAN
DESCRIPTION: RecName: Full=Thymic stromal lymphopoietin; Flags: Precursor;
FUNCTION: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
SUBUNIT: Interacts with a receptor composed of CRLF2 and IL7R.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in a number of tissues including heart, liver and prostate.
INDUCTION: Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TSLP
Diseases sorted by gene-association score: cryoglobulinemia, familial mixed (18), cryoglobulinemia (17), allergic asthma (14), eczema herpeticum (12), membranoproliferative glomerulonephritis (12), atopic dermatitis (10), allergic hypersensitivity disease (9), esophagitis (8), dermatitis (8), kimura disease (8), esophagitis, eosinophilic, 1 (8), asthma (6), gastrointestinal allergy (6), chronic conjunctivitis (6), keratoconjunctivitis (6), nasal cavity disease (5), nose disease (5), upper respiratory tract disease (5), esophageal disease (5), bronchial disease (5), common cold (4), respiratory system disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.33 RPKM in Testis
Total median expression: 21.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.90178-0.286 Picture PostScript Text
3' UTR -463.401952-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15216 - Thymic stromal lymphopoietin

ModBase Predicted Comparative 3D Structure on Q969D9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005139 interleukin-7 receptor binding

Biological Process:
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0032722 positive regulation of chemokine production
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032755 positive regulation of interleukin-6 production
GO:0033005 positive regulation of mast cell activation
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043066 negative regulation of apoptotic process
GO:0044140 negative regulation of growth of symbiont on or near host surface
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0050832 defense response to fungus
GO:0071654 positive regulation of chemokine (C-C motif) ligand 1 production
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:1904894 positive regulation of STAT cascade
GO:2000664 positive regulation of interleukin-5 secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC040592 - Homo sapiens thymic stromal lymphopoietin, mRNA (cDNA clone MGC:43586 IMAGE:5269764), complete cds.
AY037115 - Homo sapiens thymic stromal lymphopoietin (TSLP) mRNA, complete cds.
HH937573 - Sequence 149 from Patent WO2010111490.
HV964815 - JP 2012521764-A/149: RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucleic Acid (siNA).
JD334575 - Sequence 315599 from Patent EP1572962.
JD370901 - Sequence 351925 from Patent EP1572962.
JD048623 - Sequence 29647 from Patent EP1572962.
JD276790 - Sequence 257814 from Patent EP1572962.
AF338732 - Homo sapiens thymic stromal lymphopoietin protein TSLP mRNA, complete cds.
AB590692 - Synthetic construct DNA, clone: pFN21AE1644, Homo sapiens TSLP gene for thymic stromal lymphopoietin, without stop codon, in Flexi system.
LG143278 - KR 1020160016475-A/32: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495171 - KR 1020170029449-A/32: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495434 - KR 1020170057194-A/32: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143280 - KR 1020160016475-A/34: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495173 - KR 1020170029449-A/34: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495436 - KR 1020170057194-A/34: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143281 - KR 1020160016475-A/35: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495174 - KR 1020170029449-A/35: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495437 - KR 1020170057194-A/35: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143283 - KR 1020160016475-A/37: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495176 - KR 1020170029449-A/37: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495439 - KR 1020170057194-A/37: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143284 - KR 1020160016475-A/38: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495177 - KR 1020170029449-A/38: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495440 - KR 1020170057194-A/38: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143286 - KR 1020160016475-A/40: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495179 - KR 1020170029449-A/40: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495442 - KR 1020170057194-A/40: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143287 - KR 1020160016475-A/41: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495180 - KR 1020170029449-A/41: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495443 - KR 1020170057194-A/41: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143290 - KR 1020160016475-A/44: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495183 - KR 1020170029449-A/44: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495446 - KR 1020170057194-A/44: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143292 - KR 1020160016475-A/46: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495185 - KR 1020170029449-A/46: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495448 - KR 1020170057194-A/46: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143295 - KR 1020160016475-A/49: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495188 - KR 1020170029449-A/49: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495451 - KR 1020170057194-A/49: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143248 - KR 1020160016475-A/2: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495141 - KR 1020170029449-A/2: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495404 - KR 1020170057194-A/2: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143250 - KR 1020160016475-A/4: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495143 - KR 1020170029449-A/4: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495406 - KR 1020170057194-A/4: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143253 - KR 1020160016475-A/7: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495146 - KR 1020170029449-A/7: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495409 - KR 1020170057194-A/7: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143298 - KR 1020160016475-A/52: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495191 - KR 1020170029449-A/52: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495454 - KR 1020170057194-A/52: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143301 - KR 1020160016475-A/55: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495194 - KR 1020170029449-A/55: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495457 - KR 1020170057194-A/55: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143302 - KR 1020160016475-A/56: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495195 - KR 1020170029449-A/56: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495458 - KR 1020170057194-A/56: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
AL833421 - Homo sapiens mRNA; cDNA DKFZp313D1939 (from clone DKFZp313D1939).
BC022894 - Homo sapiens thymic stromal lymphopoietin, mRNA (cDNA clone IMAGE:4690723), complete cds.
BC016720 - Homo sapiens thymic stromal lymphopoietin, mRNA (cDNA clone IMAGE:4074772), complete cds.
LG143256 - KR 1020160016475-A/10: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495149 - KR 1020170029449-A/10: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495412 - KR 1020170057194-A/10: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143257 - KR 1020160016475-A/11: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495150 - KR 1020170029449-A/11: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495413 - KR 1020170057194-A/11: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143259 - KR 1020160016475-A/13: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495152 - KR 1020170029449-A/13: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495415 - KR 1020170057194-A/13: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143260 - KR 1020160016475-A/14: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495153 - KR 1020170029449-A/14: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495416 - KR 1020170057194-A/14: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143262 - KR 1020160016475-A/16: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495155 - KR 1020170029449-A/16: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495418 - KR 1020170057194-A/16: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143265 - KR 1020160016475-A/19: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495158 - KR 1020170029449-A/19: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495421 - KR 1020170057194-A/19: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143266 - KR 1020160016475-A/20: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495159 - KR 1020170029449-A/20: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495422 - KR 1020170057194-A/20: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143268 - KR 1020160016475-A/22: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495161 - KR 1020170029449-A/22: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495424 - KR 1020170057194-A/22: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143271 - KR 1020160016475-A/25: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495164 - KR 1020170029449-A/25: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495427 - KR 1020170057194-A/25: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
JD289137 - Sequence 270161 from Patent EP1572962.
KJ904935 - Synthetic construct Homo sapiens clone ccsbBroadEn_14329 TSLP gene, encodes complete protein.
LG143305 - KR 1020160016475-A/59: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495198 - KR 1020170029449-A/59: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495461 - KR 1020170057194-A/59: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143307 - KR 1020160016475-A/61: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495200 - KR 1020170029449-A/61: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495463 - KR 1020170057194-A/61: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143311 - KR 1020160016475-A/65: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495204 - KR 1020170029449-A/65: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495467 - KR 1020170057194-A/65: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143313 - KR 1020160016475-A/67: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495206 - KR 1020170029449-A/67: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495469 - KR 1020170057194-A/67: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143314 - KR 1020160016475-A/68: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495207 - KR 1020170029449-A/68: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495470 - KR 1020170057194-A/68: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143274 - KR 1020160016475-A/28: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495167 - KR 1020170029449-A/28: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495430 - KR 1020170057194-A/28: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LG143277 - KR 1020160016475-A/31: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495170 - KR 1020170029449-A/31: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
LY495433 - KR 1020170057194-A/31: Oligonucleotides down-regulating the expression of TSLP and the composites for cosmetic or pharmaceutical.
JD284085 - Sequence 265109 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q969D9 (Reactome details) participates in the following event(s):

R-HSA-1266695 Interleukin-7 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000344895.1, ENST00000344895.2, ENST00000344895.3, G3XAM8, NM_033035, Q8IW99, Q969D9, Q96AU7, TSLP_HUMAN, uc317xcn.1, uc317xcn.2
UCSC ID: ENST00000344895.4_8
RefSeq Accession: NM_033035.5
Protein: Q969D9 (aka TSLP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.