Human Gene TSR1 (ENST00000301364.10_6) from GENCODE V47lift37
Description: TSR1 ribosome maturation factor (from RefSeq NM_018128.5)
Gencode Transcript: ENST00000301364.10_6
Gencode Gene: ENSG00000167721.11_9
Transcript (Including UTRs)
Position: hg19 chr17:2,225,690-2,239,751 Size: 14,062 Total Exon Count: 15 Strand: -
Coding Region
Position: hg19 chr17:2,227,490-2,239,721 Size: 12,232 Coding Exon Count: 15
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TSR1_HUMAN
DESCRIPTION: RecName: Full=Pre-rRNA-processing protein TSR1 homolog;
FUNCTION: Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity).SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity).SIMILARITY: Belongs to the BMS1/TSR1 family. TSR1 subfamily.SEQUENCE CAUTION: Sequence=BAA91667.1; Type=Erroneous initiation; Sequence=BAA92639.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR012948 - AARP2CN
IPR007034 - BMS1_TSR1_C
Pfam Domains: PF04950 - 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
PF08142 - AARP2CN (NUC121) domain
SCOP Domains: 50447 - Translation proteins
ModBase Predicted Comparative 3D Structure on Q2NL82
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF209189 - JP 2014500723-A/16692: Polycomb-Associated Non-Coding RNAs.AK026565 - Homo sapiens cDNA: FLJ22912 fis, clone KAT06132.BC019090 - Homo sapiens TSR1, 20S rRNA accumulation, homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4896567), partial cds.BC110851 - Homo sapiens TSR1, 20S rRNA accumulation, homolog (S. cerevisiae), mRNA (cDNA clone MGC:131829 IMAGE:5786818), complete cds.BC126110 - Homo sapiens TSR1, 20S rRNA accumulation, homolog (S. cerevisiae), mRNA (cDNA clone MGC:161388 IMAGE:8991826), complete cds.AB037822 - Homo sapiens KIAA1401 mRNA for KIAA1401 protein.AK001396 - Homo sapiens cDNA FLJ10534 fis, clone NT2RP2001065.KJ902866 - Synthetic construct Homo sapiens clone ccsbBroadEn_12260 TSR1 gene, encodes complete protein.KJ899176 - Synthetic construct Homo sapiens clone ccsbBroadEn_08570 TSR1 gene, encodes complete protein.AB463326 - Synthetic construct DNA, clone: pF1KA1401, Homo sapiens TSR1 gene for TSR1, 20S rRNA accumulation, homolog, without stop codon, in Flexi system.MA444766 - JP 2018138019-A/16692: Polycomb-Associated Non-Coding RNAs.JD411795 - Sequence 392819 from Patent EP1572962.JD139079 - Sequence 120103 from Patent EP1572962.JD056820 - Sequence 37844 from Patent EP1572962.JD165427 - Sequence 146451 from Patent EP1572962.JD327276 - Sequence 308300 from Patent EP1572962.JD042111 - Sequence 23135 from Patent EP1572962.JD435814 - Sequence 416838 from Patent EP1572962.JD530031 - Sequence 511055 from Patent EP1572962.JD557614 - Sequence 538638 from Patent EP1572962.JD430594 - Sequence 411618 from Patent EP1572962.JD324128 - Sequence 305152 from Patent EP1572962.JD329402 - Sequence 310426 from Patent EP1572962.JD144565 - Sequence 125589 from Patent EP1572962.JD119085 - Sequence 100109 from Patent EP1572962.JD511528 - Sequence 492552 from Patent EP1572962.JD286690 - Sequence 267714 from Patent EP1572962.JD128015 - Sequence 109039 from Patent EP1572962.JD561257 - Sequence 542281 from Patent EP1572962.JD101841 - Sequence 82865 from Patent EP1572962.JD356016 - Sequence 337040 from Patent EP1572962.JD293831 - Sequence 274855 from Patent EP1572962.JD565199 - Sequence 546223 from Patent EP1572962.JD239194 - Sequence 220218 from Patent EP1572962.JD057495 - Sequence 38519 from Patent EP1572962.JD114734 - Sequence 95758 from Patent EP1572962.JD451031 - Sequence 432055 from Patent EP1572962.JD558215 - Sequence 539239 from Patent EP1572962.JD051938 - Sequence 32962 from Patent EP1572962.JD202698 - Sequence 183722 from Patent EP1572962.JD205959 - Sequence 186983 from Patent EP1572962.JD042997 - Sequence 24021 from Patent EP1572962.JD551923 - Sequence 532947 from Patent EP1572962.JD243787 - Sequence 224811 from Patent EP1572962.DQ596113 - Homo sapiens piRNA piR-34179, complete sequence.LF326718 - JP 2014500723-A/134221: Polycomb-Associated Non-Coding RNAs.CU676378 - Synthetic construct Homo sapiens gateway clone IMAGE:100019984 5' read TSR1 mRNA.LF326717 - JP 2014500723-A/134220: Polycomb-Associated Non-Coding RNAs.LF326716 - JP 2014500723-A/134219: Polycomb-Associated Non-Coding RNAs.DQ585510 - Homo sapiens piRNA piR-52622, complete sequence.LF326714 - JP 2014500723-A/134217: Polycomb-Associated Non-Coding RNAs.LF326713 - JP 2014500723-A/134216: Polycomb-Associated Non-Coding RNAs.LF326712 - JP 2014500723-A/134215: Polycomb-Associated Non-Coding RNAs.AJ276247 - Homo sapiens partial mRNA, clone c1-1c9.LF326711 - JP 2014500723-A/134214: Polycomb-Associated Non-Coding RNAs.JD209574 - Sequence 190598 from Patent EP1572962.JD296938 - Sequence 277962 from Patent EP1572962.LF326710 - JP 2014500723-A/134213: Polycomb-Associated Non-Coding RNAs.LF326709 - JP 2014500723-A/134212: Polycomb-Associated Non-Coding RNAs.JD270829 - Sequence 251853 from Patent EP1572962.LF326708 - JP 2014500723-A/134211: Polycomb-Associated Non-Coding RNAs.JD104095 - Sequence 85119 from Patent EP1572962.JD180674 - Sequence 161698 from Patent EP1572962.LF326706 - JP 2014500723-A/134209: Polycomb-Associated Non-Coding RNAs.MA562295 - JP 2018138019-A/134221: Polycomb-Associated Non-Coding RNAs.MA562294 - JP 2018138019-A/134220: Polycomb-Associated Non-Coding RNAs.MA562293 - JP 2018138019-A/134219: Polycomb-Associated Non-Coding RNAs.MA562291 - JP 2018138019-A/134217: Polycomb-Associated Non-Coding RNAs.MA562290 - JP 2018138019-A/134216: Polycomb-Associated Non-Coding RNAs.MA562289 - JP 2018138019-A/134215: Polycomb-Associated Non-Coding RNAs.MA562288 - JP 2018138019-A/134214: Polycomb-Associated Non-Coding RNAs.MA562287 - JP 2018138019-A/134213: Polycomb-Associated Non-Coding RNAs.MA562286 - JP 2018138019-A/134212: Polycomb-Associated Non-Coding RNAs.MA562285 - JP 2018138019-A/134211: Polycomb-Associated Non-Coding RNAs.MA562283 - JP 2018138019-A/134209: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000301364.1, ENST00000301364.2, ENST00000301364.3, ENST00000301364.4, ENST00000301364.5, ENST00000301364.6, ENST00000301364.7, ENST00000301364.8, ENST00000301364.9, KIAA1401, NM_018128, Q2NL82, Q8WUY5, Q9NVT0, Q9P2E6, TSR1_HUMAN, uc317mui.1, uc317mui.2UCSC ID: ENST00000301364.10_6RefSeq Accession: NM_018128.5
Protein: Q2NL82
(aka TSR1_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.