Human Gene TTC33 (ENST00000337702.5_7) from GENCODE V47lift37

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Description: tetratricopeptide repeat domain 33 (from RefSeq NM_012382.3)
Gencode Transcript: ENST00000337702.5_7
Gencode Gene: ENSG00000113638.14_10
Transcript (Including UTRs)
Position: hg19 chr5:40,711,678-40,756,063 Size: 44,386 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr5:40,716,247-40,747,120 Size: 30,874 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:40,711,678-40,756,063)			mRNA (may differ from genome)		Protein (262 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TTC33_HUMAN DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 33; Short=TPR repeat protein 33; AltName: Full=Osmosis-responsive factor; SIMILARITY: Contains 3 TPR repeats.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D019256 Cadmium Chloride D019327 Copper Sulfate D016572 Cyclosporine D011794 Quercetin D013749 Tetrachlorodibenzodioxin D015032 Zinc

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 8.35 RPKM in Brain - Cerebellar Hemisphere Total median expression: 245.01 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-53.80	139	-0.387	Picture	PostScript	Text
3' UTR	-1036.90	4569	-0.227	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q6PID6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding

Descriptions from all associated GenBank mRNAs


	LF210219 - JP 2014500723-A/17722: Polycomb-Associated Non-Coding RNAs. MA445796 - JP 2018138019-A/17722: Polycomb-Associated Non-Coding RNAs. AF130073 - Homo sapiens clone FLB9215 PRO2476 mRNA, complete cds. BC036536 - Homo sapiens tetratricopeptide repeat domain 33, mRNA (cDNA clone MGC:33759 IMAGE:5262401), complete cds. BC015701 - Homo sapiens tetratricopeptide repeat domain 33, mRNA (cDNA clone MGC:10173 IMAGE:3907836), complete cds. AF023244 - Homo sapiens osmosis responsive factor mRNA, complete cds. JD245490 - Sequence 226514 from Patent EP1572962. JD551668 - Sequence 532692 from Patent EP1572962. JD234775 - Sequence 215799 from Patent EP1572962. JD096733 - Sequence 77757 from Patent EP1572962. JD091682 - Sequence 72706 from Patent EP1572962. AK307131 - Homo sapiens cDNA, FLJ97079. JD241201 - Sequence 222225 from Patent EP1572962. JD491477 - Sequence 472501 from Patent EP1572962. JD295244 - Sequence 276268 from Patent EP1572962. JD233389 - Sequence 214413 from Patent EP1572962. JD562438 - Sequence 543462 from Patent EP1572962. AK303119 - Homo sapiens cDNA FLJ61006 complete cds, highly similar to Homo sapiens osmosis responsive factor (OSRF), mRNA. JD114077 - Sequence 95101 from Patent EP1572962. AK312560 - Homo sapiens cDNA, FLJ92933, Homo sapiens osmosis responsive factor (OSRF), mRNA. KJ893398 - Synthetic construct Homo sapiens clone ccsbBroadEn_02792 TTC33 gene, encodes complete protein. DQ892364 - Synthetic construct clone IMAGE:100004994; FLH185604.01X; RZPDo839C12148D osmosis responsive factor (OSRF) gene, encodes complete protein. DQ895573 - Synthetic construct Homo sapiens clone IMAGE:100010033; FLH185600.01L; RZPDo839C12147D osmosis responsive factor (OSRF) gene, encodes complete protein. JD102968 - Sequence 83992 from Patent EP1572962. JD409974 - Sequence 390998 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2R6G0, ENST00000337702.1, ENST00000337702.2, ENST00000337702.3, ENST00000337702.4, NM_012382, O95105, Q6PID6, TTC33_HUMAN, uc317uvh.1, uc317uvh.2 UCSC ID: ENST00000337702.5_7 RefSeq Accession: NM_012382.3 Protein: Q6PID6 (aka TTC33_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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