Human Gene TTPAL (ENST00000262605.9_4) from GENCODE V47lift37
  Description: alpha tocopherol transfer protein like, transcript variant 2 (from RefSeq NM_001039199.3)
Gencode Transcript: ENST00000262605.9_4
Gencode Gene: ENSG00000124120.11_7
Transcript (Including UTRs)
   Position: hg19 chr20:43,104,514-43,123,244 Size: 18,731 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr20:43,108,640-43,118,182 Size: 9,543 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:43,104,514-43,123,244)mRNA (may differ from genome)Protein (342 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TTPAL_HUMAN
DESCRIPTION: RecName: Full=Alpha-tocopherol transfer protein-like;
FUNCTION: May act as a protein that binds a hydrophobic ligand (Potential).
SIMILARITY: Contains 1 CRAL-TRIO domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.55 RPKM in Cells - Cultured fibroblasts
Total median expression: 193.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.50133-0.568 Picture PostScript Text
3' UTR -1598.805062-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001071 - CRAL-bd_toc_tran
IPR001251 - CRAL-TRIO_dom
IPR011074 - CRAL/TRIO_N_dom

Pfam Domains:
PF00650 - CRAL/TRIO domain
PF03765 - CRAL/TRIO, N-terminal domain
PF13716 - Divergent CRAL/TRIO domain

SCOP Domains:
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain

ModBase Predicted Comparative 3D Structure on Q9BTX7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  CR936621 - Homo sapiens mRNA; cDNA DKFZp686E0870 (from clone DKFZp686E0870).
AK056178 - Homo sapiens cDNA FLJ31616 fis, clone NT2RI2003019.
BC003071 - Homo sapiens tocopherol (alpha) transfer protein-like, mRNA (cDNA clone MGC:2470 IMAGE:2989837), complete cds.
AK314045 - Homo sapiens cDNA, FLJ94708.
AK307236 - Homo sapiens cDNA, FLJ97184.
AB529057 - Synthetic construct DNA, clone: pF1KB3746, Homo sapiens TTPAL gene for Alpha-tocopherol transfer-like protein, without stop codon, in Flexi system.
KJ894674 - Synthetic construct Homo sapiens clone ccsbBroadEn_04068 TTPAL gene, encodes complete protein.
JD520182 - Sequence 501206 from Patent EP1572962.
JD319214 - Sequence 300238 from Patent EP1572962.
AK125126 - Homo sapiens cDNA FLJ43136 fis, clone CTONG3006650.
JD073553 - Sequence 54577 from Patent EP1572962.
JD052532 - Sequence 33556 from Patent EP1572962.
JD126338 - Sequence 107362 from Patent EP1572962.
JD467599 - Sequence 448623 from Patent EP1572962.
JD251336 - Sequence 232360 from Patent EP1572962.
JD137325 - Sequence 118349 from Patent EP1572962.
JD300924 - Sequence 281948 from Patent EP1572962.
JD497565 - Sequence 478589 from Patent EP1572962.
JD542191 - Sequence 523215 from Patent EP1572962.
JD542192 - Sequence 523216 from Patent EP1572962.
JD408609 - Sequence 389633 from Patent EP1572962.
JD524620 - Sequence 505644 from Patent EP1572962.
JD469560 - Sequence 450584 from Patent EP1572962.
JD176762 - Sequence 157786 from Patent EP1572962.
JD414241 - Sequence 395265 from Patent EP1572962.
JD185677 - Sequence 166701 from Patent EP1572962.
JD184733 - Sequence 165757 from Patent EP1572962.
JD412340 - Sequence 393364 from Patent EP1572962.
DQ576507 - Homo sapiens piRNA piR-44619, complete sequence.
JD379207 - Sequence 360231 from Patent EP1572962.
JD302495 - Sequence 283519 from Patent EP1572962.
JD078829 - Sequence 59853 from Patent EP1572962.
JD462767 - Sequence 443791 from Patent EP1572962.
JD422061 - Sequence 403085 from Patent EP1572962.
JD327160 - Sequence 308184 from Patent EP1572962.
JD561178 - Sequence 542202 from Patent EP1572962.
JD204571 - Sequence 185595 from Patent EP1572962.
JD428824 - Sequence 409848 from Patent EP1572962.
JD502425 - Sequence 483449 from Patent EP1572962.
JD036856 - Sequence 17880 from Patent EP1572962.
JD041466 - Sequence 22490 from Patent EP1572962.
JD041467 - Sequence 22491 from Patent EP1572962.
JD447065 - Sequence 428089 from Patent EP1572962.
JD443366 - Sequence 424390 from Patent EP1572962.
JD092101 - Sequence 73125 from Patent EP1572962.
JD292596 - Sequence 273620 from Patent EP1572962.
JD534880 - Sequence 515904 from Patent EP1572962.
JD366730 - Sequence 347754 from Patent EP1572962.
JD220077 - Sequence 201101 from Patent EP1572962.
JD357180 - Sequence 338204 from Patent EP1572962.
JD323940 - Sequence 304964 from Patent EP1572962.
JD432292 - Sequence 413316 from Patent EP1572962.
JD229682 - Sequence 210706 from Patent EP1572962.
JD453797 - Sequence 434821 from Patent EP1572962.
JD348138 - Sequence 329162 from Patent EP1572962.
JD500043 - Sequence 481067 from Patent EP1572962.
JD288470 - Sequence 269494 from Patent EP1572962.
JD249648 - Sequence 230672 from Patent EP1572962.
JD378143 - Sequence 359167 from Patent EP1572962.
JD426697 - Sequence 407721 from Patent EP1572962.
JD546456 - Sequence 527480 from Patent EP1572962.
JD222258 - Sequence 203282 from Patent EP1572962.
JD430474 - Sequence 411498 from Patent EP1572962.
JD557537 - Sequence 538561 from Patent EP1572962.
JD529707 - Sequence 510731 from Patent EP1572962.
JD434915 - Sequence 415939 from Patent EP1572962.
JD434916 - Sequence 415940 from Patent EP1572962.
JD307086 - Sequence 288110 from Patent EP1572962.
JD322965 - Sequence 303989 from Patent EP1572962.
JD401631 - Sequence 382655 from Patent EP1572962.
JD142719 - Sequence 123743 from Patent EP1572962.
JD334159 - Sequence 315183 from Patent EP1572962.
JD096088 - Sequence 77112 from Patent EP1572962.
JD043325 - Sequence 24349 from Patent EP1572962.
JD330029 - Sequence 311053 from Patent EP1572962.
JD173918 - Sequence 154942 from Patent EP1572962.
JD323994 - Sequence 305018 from Patent EP1572962.
JD147010 - Sequence 128034 from Patent EP1572962.
JD511084 - Sequence 492108 from Patent EP1572962.
JD354050 - Sequence 335074 from Patent EP1572962.
JD269660 - Sequence 250684 from Patent EP1572962.
JD518958 - Sequence 499982 from Patent EP1572962.
JD113674 - Sequence 94698 from Patent EP1572962.
JD345012 - Sequence 326036 from Patent EP1572962.
DQ585231 - Homo sapiens piRNA piR-52343, complete sequence.
JD080945 - Sequence 61969 from Patent EP1572962.
JD155272 - Sequence 136296 from Patent EP1572962.
JD259450 - Sequence 240474 from Patent EP1572962.
JD052929 - Sequence 33953 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C20orf121, E1P5X3, ENST00000262605.1, ENST00000262605.2, ENST00000262605.3, ENST00000262605.4, ENST00000262605.5, ENST00000262605.6, ENST00000262605.7, ENST00000262605.8, NM_001039199, Q5QPC1, Q9BTX7, Q9H1G2, Q9NQG8, TTPAL_HUMAN, uc317hbv.1, uc317hbv.2
UCSC ID: ENST00000262605.9_4
RefSeq Accession: NM_001039199.3
Protein: Q9BTX7 (aka TTPAL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.